Tony Bai

Concomitant use of lansoprazole and ceftriaxone is associated with an increased risk of ventricular arrhythmias and cardiac arrest in a large Japanese hospital database To determine whether concomitant use of ceftriaxone and oral or intravenous lansoprazole increases the risk of ventricular arrhythmia and cardiac arrest in the real-world setting in Japan.

There is another recent study finding a similar signal that better addresses the confounding issue than our JAMA Network paper by using Ampicillin Sulbactam plus Lansoprazole as a comparison group

www.journalofinfection.com/article/S016...

Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation - PubMed Coupling data mining and laboratory experiments is an efficient method for identifying QT-DDIs. Combination therapy of ceftriaxone and lansoprazole is associated with increased risk of acquired long Q...

The proposed mechanism is that the combination block the hERG channel, based on this paper:

pubmed.ncbi.nlm.nih.gov/27737742/

Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection Abstract. Antibiotic prophylaxis is often recommended for close contacts of index cases of invasive Streptococcus pyogenes infections. Using MarketScan dat

🆕️⚡️⚡️ #CIDJournal
Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection
No difference in infection rates between those who received and those who did not receive antibiotic #idsky #medsky
academic.oup.com/cid/advance-...

I usually do 7 days from the last debridement which I regard as definitive source control.