Dmitriy

Once a Death Sentence, This Heart Condition Is Finally Treatable

🧪Once a Death Sentence, This Heart Condition Is Finally Treatable

A quiet revolution in care is helping patients with cardiac amyloidosis, a form of heart failure that long stumped doctors.

www.nytimes.com/2025/08/04/w...

Hi Nick, happy to help with beta testing.

Figure showing that the mortality rate of SMA in 2024 has dropped nearly 80% since 2014, having decreased from 1.84 per 100 individuals to 0.42 per 100 individuals with SMA.

Some uplifting 🧪news from the latest Cure SMA annual report:

The mortality rate of SMA in 2024 has dropped nearly 80% since 2014.

Why? Newborn screening = earlier treatment & 3 FDA-approved therapies.

ICER is currently reviewing a fourth therapy: icer.org/assessment/s...

@charlespiller.bsky.social recently wrote a great book on ALZ and scientific misconduct in the field

The Google AI slop is relentless

@kagi.com seems to get it right.

Thanks for reaching out, Stefan. Just added you 😊

The Wayback Machine by the @archive.org does a great job of backing up ClinicalTrials.gov (and millions of other sites!)

Example: web.archive.org/web/20241116...

So pleased to be able to join Mike DiStefano and Wija Oortwijn to discuss #HTA activities in the context of serious affordability challenges. You should join us too!

He looks like a very kind man. So sorry for your loss, Gabe.

🧪This morning, ICER announces a new review of 4 spinal muscular atrophy (SMA) therapies. With widespread US newborn screening & improved patient longevity, we're eager to assess progress in this rapidly advancing field since our 2019 report. #healthpolicy

Draft scope below:
icer.org/wp-content/u...

Great picks! Based on your list, I think you may also enjoy Timberborn 🦫

Havis and snow are a beautiful combo. 😍

ICER Identifies 5 Drugs with Unsupported Price Increases The Institute for Clinical and Economic Review has identified five drugs — Biktarvy, Darzalex, Entresto, Cabometyx, and Xeljanz — with prices increases that are not supported by new clinical evidence,...

The Institute for Clinical and Economic Review has identified 5 drugs with price increases not supported by new clinical evidence:
Biktarvy
Darzalex
Entresto
Cabometyx
Xeljanz
www.managedhealthcareexecutive.com/view/icer-id...

Salmon return to lay eggs in historic habitat after largest dam removal project in US history Less than a month after four towering dams on the Klamath River were demolished, hundreds of salmon made it into waters they have been cut off from for decades to spawn in cool creeks.

🧪 Less than a month after four towering dams on the Klamath River were demolished, hundreds of salmon made it into waters they have been cut off from for decades to spawn in cool creeks

bsky.app/profile/dmit...

Summary of ICER's October ATTR-CM report here: icer.org/wp-content/u...

BridgeBio wins FDA approval for heart disease drug The FDA approved a new medicine from BridgeBio for patients with ATTR-CM, a progressive heart disease

🧪A second drug for transthyretin amyloid cardiomyopathy just got approved a week early.

At $225K/year, it's more accessible than Pfizer's $268K Vyndaqel but still far exceeds ICER's recommended $13.6K-$39K range.

Big news for the 50,000+ patients in US, but pricing debate continues.

A nice no-AI selection of fat cats

Not sure what your tolerance is for paid search engines, but @kagi.com recently updated their image search to have a "No AI" filter that's perfect for your use case.

The grey lit and additional citations are definitely a plus!

Are you familiar with openalex.org ?

I've been slowly migrating my GScholar searches over to OA due to them being open-source/nonprofit.

Welcome, Kent! You may find the demography feed useful to connect with colleagues bsky.app/profile/dmit...

Knowledge, attitudes, and concerns about psilocybin and MDMA as novel therapies among U.S. healthcare professionals - Scientific Reports Scientific Reports - Knowledge, attitudes, and concerns about psilocybin and MDMA as novel therapies among U.S. healthcare professionals

🧪A survey of 879 U.S. healthcare professionals found:

Popular media (69.5%psilocybin, 61.8% MDMA) and academic literature (65.6%, 47.9%) were respondents’ main current sources of knowledge

Only 5.5% answered all 3 knowledge check questions correctly for psilocybin compared to just 1.1% for MDMA.

The Takeaway From Study of Midlife MS Patients: Don't Stop Disease-Modifying Therapy People with multiple sclerosis (MS) often stop taking disease-modifying therapy as they transition from relapsing-remitting MS to secondary progressive MS. This study shows that people who stop stop…

🧪 People with MS often stop taking disease-modifying therapy as they transition from relapsing-remitting MS to secondary progressive MS. This study shows that people who stop stop therapy have higher hospitalization rates and more visits to the emergency room.

20 things you didn’t know about Google Scholar Google Scholar celebrates two decades of breaking down barriers to academic research and making it accessible to everyone, everywhere.

🧪Today is the 20 year anniversary of Google Scholar!

To celebrate the occasion, its two founders put together some fun facts related to the tool.

blog.google/outreach-ini...

This city's businesses 'went dark' to reduce bird deaths — and it worked A hotspot for bird migration, this region has now found success in reducing avian deaths, simply by turning off the lights.

🧪 Experts found the Texas DFW area to be the third most dangerous for migrating birds. To help, the Lights Out team convinced downtown businesses to dim their lights, reducing confusion for birds. By Oct. 31, bird deaths dropped to 42, down from 110 last fall.

You can use this tool! nws-bot.us/bskyStarterP...

Gophers were given one day to revive Mount St. Helens — and their impact on its ecosystem has lasted decades By unearthing microbes and fungi, these rodents helped save an ecosystem almost decimated by the eruption of Mount St. Helens.

🧪In 1980, Mount St. Helens erupted in Washington, destroying everything nearby. Gophers helped restore the soil by spreading microbes. Their digging resulted in 40,000 new plants in six years, leading to a thriving forest today.

An attempt to repeal Washington's landmark climate law failed massively "Every state legislator can now look to Washington and say, ‘This is a winning issue,’” Governor Jay Inslee told Grist.

🧪 Washington state's voters upheld the Climate Commitment Act, a cap-and-trade law, by rejecting a repeal. This law has raised over $2 billion for clean transportation, clean energy, and climate adaptation efforts, with 62% voting to maintain it.

Sure thing Valentin, just added you!

Thank you, I've added both