I appreciated the reflection on how insane 18th and 19th century science seemed. What do you mean you put a dog's brain into a rabbit's brain? Wait, you are carefully observing a sealed dead eel?

THIS is what I need no more ryan lizza and so forth etc

Attenuation Is All You Need (Well, inactivation too)

We cover the invention of 20 vaccines from the 1700s through 1970. Technology (smallpox vaccine) preceding scientific understanding (germ theory), then speeding up once theory established from experiments (maggots…) & new tools made (agar plates)

Some news: Open Philanthropy is now Coefficient Giving! Our mission is unchanged but the new name reflects our growing work with other donors to multiply the impact of their giving.

🧵 on our work to make philanthropy a more efficient "market" and plans going forward:

Some amazing jobs here! Our science and global health R&D team works on funding breakthroughs for neglected, high mortality/morbidity diseases and does a ton of great and interesting work -- see job links in Jacob's thread!

Hiring scientists to give away money At Open Philanthropy, we have given away $600 million in biomedical research since 2016. That funding has supported the work of thousands of scientists across hundreds of universities, nonprofits, and...

I blogged more about the roles here: blog.jacobtrefethen.com/hiring/

Please share the job descriptions with colleagues and friends who you think may be interested! 🙏

Screenshot of Open Philanthropy blog post on 5 science giving highlights

You can get a sense of what we support from this piece last year. We fund whatever we believe is important, neglected, and tractable across many areas of discovery and translation, which leads to a broad portfolio. Generalists very much welcome!

www.openphilanthropy.org/research/fiv...

Program Officer, Science and Global Health R&D Open Philanthropy is seeking a Program Officer to execute, expand, and refine our existing grantmaking strategies in Global Health R&D.

Hiring a PO to help us give away tens of millions more in vaccine R&D over the coming years, in particular to make progress on strep A. Kills 600k/y but should be fixable with creativity...

Looking for an experienced scientist, but not necessarily in strep A:

jobs.ashbyhq.com/openphilanth...

Senior Program Associates, Science and Global Health R&D Open Philanthropy is looking for multiple Senior Program Associates to support our grantmaking aimed at improving global health through scientific research and R&D

Senior Program Associates will work closely with our existing (world class!) POs to help scale grantmaking

Variety of research & analysis, interacting with grantees, portfolio management

Fun for people with technical backgrounds who are impact focused:

jobs.ashbyhq.com/openphilanth...

Hiring scientists to give away money At Open Philanthropy, we have given away $600 million in biomedical research since 2016. That funding has supported the work of thousands of scientists across hundreds of universities, nonprofits, and...

🚨 Hiring scientists to help give away money 🚨

At Open Philanthropy, we have given away $600M in biomedical research since 2016. Now, we're expanding the team to do more.

We're hiring:
* Up to 3 Senior Program Associates
* Program Officer in strep A

Remote OK, salaries in links! (Thread below)

This one is kind of for you tbh, made us happy to think of your reaction if we dropped it

And then if that all looks good, you're going to submit a huge data package to the FDA and say, "Can I please sell this drug in America?" The FDA will take 6 to 10 months and review your data, review your thousands of pages of submission and get back to you with a thumbs up or a thumbs down. After you're selling your drug, you're still collecting data. The FDA might require further studies after they approve your drug if there are particular questions they have that things should be addressed. If in those studies you end up with a negative result, they might withdraw your ability to sell the drug; that happens somewhat frequently. Also, you're going to be collecting in the real world, more side effect data. Once hundreds of thousands of people are using a drug, you will spot more side effects. They won't be randomized, so you won't necessarily get as high quality data, but you at least get more data as things come in, so the evidence collection does not stop once you get approval. Saloni Dattani: Wow, great. That's a very long process. So I have two things about mice that I wanted to talk about.

MFW my co-host @jacobtref.bsky.social is telling me all about the drug development pipeline.

Spotify likes to do a second transcript of its own, and gave you a new name:

Will AI solve medicine? Some say AI will solve medicine within a decade. Others believe biology is far more complex than people imagine and AI will hit the limits of clinical trials and economics. Who's right?

Welp @scientificdiscovery.dev and Jacob are back again, Will AI Cure Disease? By the end of the 4.5 hours you'll be significantly older and might find out!
www.worksinprogress.news/p/will-ai-so...?

Will AI solve medicine?

We decided to be as definitive as is possible in 2025. That meant going long, through the drug development process

Sections
1. Clashing worldviews
2. Drug discovery
3. Models
4. Efficacy
5. Safety
6. Manufacturing & healthcare
7. Funding
8. Trust & ambition

Hope you enjoy!

YouTube comment that says "Fascinating! Almost didn't realise this was AI generated content until I noticed the blink rate and ran it through a model."

Apparently some people think I'm AI generated, because... I don't blink enough

Tune in to find out:

- how to go from hallucinated cat pictures to hallucinated proteins
- whether @jacobtref.bsky.social can do photosynthesis
- whether we can make tiny protein straws for tardigrades to drink from

Our most practical episode yet for people who want to dabble in biotech

As of 2022, you can hallucinate protein structures using AI similar to Midjourney (RFDiffusion) -> create amino acid strings for them (ProteinMPNN) -> validate with AlphaFold

Biology becomes engineering…

Cool episode on how AI can help us design new proteins (e.g., for vaccines).

I’d heard of AlphaFold before, but not of ProteinMPNN. You feed a protein structure into PMPNN & generate possible sequences of amino acids. And then you feed those into AlphaFold to check whether they’d fold up that way!

me too!

Hearing a lot about AI designing drugs, but not sure what specifically that means?

Ever wonder how AlphaFold works, or what practical problems it helps with?

How rattan daybeds can hold their own in a modern home?

This episode is for you!

every time i feel bad about writing long essays / blog posts i think, no. what would saloni and jacob do.

The reviews are in!

"I heard it just now! So good 😊" – my mom

"Just listened to the new insulin episode and loved it." – @rossaokod.bsky.social

"you should have added 5 more minutes on how early researchers checked for the sweetness of animal urine..." – @pseudoerasmus.bsky.social

1/3 As someone diagnosed as Type 1 in 1976, I can remember beginning on porcine insulin (bovine was another alternative). The first "human" insulin I had was actually enzymatically modified porcine. I started with glass syringes, with exchangeable all metal needles, stored in methylated spirit.

Very interesting. Thank you so much for sharing!

100 years of insulin in 15 minutes Podcast Episode · Hard Drugs · 09/16/2025 · 18m

podcasts.apple.com/us/podcast/h...

Last episode: an introduction to what proteins are

This episode: proteins can be medicines!

Insulin is a protein. 104 years ago, no one with diabetes had been injected with it, then came insulin from animals, then came bioreactors...

Saloni and Jacob have a natural way to make everything sound like it’s the coolest thing in the world, so naturally I’m now all on board of the protein train 🚂

AI for protein design won a Nobel Prize last year. Are new protein drugs to cure diseases on their way?

This episode introduces what proteins are. You can listen to it on its own, or as the first plank of us answering that question. Subscribe in a podcast app for future planks!

life of the statistical paparazzi