Andrew Plested

New paper by Kay Grobe and Seraphine Wegner @sfb1348.bsky.social @uni-muenster.de shows that the soluble factor Scube recruits proteases, protease inhibitors, and lipoproteins to the cell surface, where they release the #Sonic #Hedgehog morphogen
www.nature.com/articles/s42... @commsbio.nature.com

A delegation of German academic leadership and council visited Shenzhen labs. Strong interest in concrete collaborations @unibonn.bsky.social @unileipzig.bsky.social @uniheidelberg.bsky.social
@uni-freiburg.de @unituebingen.bsky.social
@lmu.de @unistuttgart.bsky.social @kit.edu
@tuda.bsky.social

Nach Glatteis-Chaos in Berlin: CDU und SPD schreiben neue Regeln für Streusalz und Winterdienst ins Gesetz Nach den Problemen mit Glatteis in Berlin haben sich CDU und SPD verständigt, wann künftig Streusalz auch auf Gehwegen eingesetzt werden darf. Auch für den Winterdienst soll es neue Zuständigkeiten ge...

Zukünftig sollten zuerst die Geh- und Radwege geräumt werden und dann die Straßen, fordert @antjekapek.bsky.social.
"Wenn wir schauen, wie es andere Städte machen, beispielsweise
Stockholm oder Helsinki, da habe ich kostenneutral einfach nur die
Reihenfolge der Räumpriorität geändert."

MSCA awards €404.3 million to postdoctoral researchers 1610 outstanding postdoctoral researchers were selected for funding among 17,066 applicants.

'The European Research Executive Agency (REA) received 17,066 applications for this call, of which 16,836 were eligible and were evaluated. 1610 projects were selected. This result corresponds to a 9,6% success rate.'
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...

🚨 Nerd Alert! 🚨

Guildford Cathedral was the location for the scene in The Omen where Damien freaks out with his Mum and Dad (Lee Remick and Gregory Peck) in the limo on the drive up to the entrance.

I just looked at the source code of a friend's vibecoded game, and it is probably the ugliest code I have seen in my life.

E.g.: EVERY modal (pop up) in the game is hundreds of lines of repeated code, and the game state is a 1000 line (!!!) arrow function.

It was made with the latest Claude model.

Symbiotic entrenchment through ecological Catch-22 A symbiotic rove beetle develops a stealth phenotype by silencing production of its hydrocarbon pheromones, enabling it to infiltrate ant colonies, steal ant pheromones, and achieve social acceptance ...

Symbiotic entrenchment through ecological Catch-22: Cell www.cell.com/cell/fulltex...

And formally provably so because to drive you need theory of mind. You can indeed show with maths the limits of maths since it's a formal engineered system with knowable limits, see Gödel etc. We created trains which ban humans from tracks so the system can be safely automated, not so for roads. 1/n

I don’t want to laugh at a small business but also VERY funny

'Stephen Long pioneered a multidisciplinary approach to advance our knowledge of photosynthesis, by integrating research at the molecular, cellular, organismal, and ecological levels along with a pragmatic understanding of the implications for agriculture.'
www.pnas.org/doi/10.1073/...

Another day, another #VTiSIM install 😉, and another system to support the research community @crick.ac.uk. This time with FRAP and Opto-Genentics 🎯🔬.
Thank you to the wonderful Crick Advanced Light Microscopy group (CALM).
Happy Imaging 🦠🔬💙💙💙.

I am disgusted by this company and will in the next month or so be doing the Hater’s Guide To Adobe. I will not forget what this company has done to its customers nor will I tolerate their loose financial language they use to deceive investors about the “success” of their flaccid AI play.

The Biochemical Society 2025 Awards. International Award, Professor Renae Ryan, University of Sydney. Includes photo of Prof Ryan and Biochemical Society awards logo.

Internationally renowned as one of the leaders in neurotransmitter transport research, don't miss Professor Renae Ryan (@renaeryan.bsky.social) present her #BiochemSoc International Award Lecture at Membrane #Proteins Conference 2026! 🧪

Spectacular.

One of the funniest conversations I've ever had with Claude...

stick with it through the third image to watch it slowly realize it's broken, try to "play it cool", fail spectacularly, then attempt self-aware commentary and immediately faceplant again.

it's worth it, I promise.

Seminar announcement for Max Planck Seminar Freiburg titled 'Super-resolution imaging of chromatin in health and disease' with date, time, location, and speaker Melike Lakadamyali from University of Pennsylvania Philadelphia USA

This Friday (today), we’re pleased to welcome Melike Lakadamyali (@melikel.bsky.social) from @upenn.edu.

If you are interested in Super resolution microscopy, cytoplasmic and nuclear organization with a focus on biophysics, then do not miss Prof. Lakadamyali talk in our lecture hall at 13:00. 🤗

I've joined the Editorial Board of @plosbiology.org

PLOS Biology is the flagship #PLOS journal in the Life Sciences. I'm looking forward to handling terrific cell biology papers for them.

#CellBiology

This is disgusting

One of those rare scientists who was elevated to the status of a book.

By the 1990s, his manual, “Molecular Cloning” was known, simply, as “Maniatis”.

cf Hille

Brilliant sunshine at the top of Veteranenstr. Berlin.

Fran! Look out the window!

🧠 How do brain organoids help researchers study the earliest stages of Alzheimer’s disease?

#mdcBerlin's Agnieszka Rybak-Wolf explains what drives her and how advanced brain organoid models help her team explore how the disease may be initiated.

🔗 Full article: www.mdc-berlin.de/news/news/ag...

a scorcher 🔥

European Scientists who said NO to Epstein-funding are the heroines of this hour🦸‍♀️

They show: It was your choice to SAY NO to Epstein's $ as scientist- you just had to have ethics & a spine

Kudos to Physicist IVETTE FUENTES who said NO

She was working at @quantumunivie.bsky.social @univie.ac.at

Careful what you wish for!

bsky.app/profile/dave...

But I do agree, with that little bit of wind, today was proper cold in Berlin.

Graphical abstract of pre-print

Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.

Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.

doi.org/10.64898/202...

Open letter from Ian Chapman to research and innovation community UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.

In short, hold your breath and hope things will turn out to be not much worse than they are now. www.ukri.org/news/open-le...

Structure of a FLAG peptide bound to anti-FLAG M2 as determined by X-ray crystallography

I am excited to share that I will be starting my lab @Sanquin-forlife Research in Amsterdam this month! Looking forward to do structural biology and use protein engineering to tackle important questions related to 🩸blood🩸 protein complexes in health and disease.
🧬🧫🔬🧪👨‍🔬
#cryoEM #xtallography

LOL

A pic by Steinmetz. The aerial pic shows what seems like a group of camels in the desert from the side, but in reality what we're seeing is their shadows. The camels are there, but we're watching them from above.

A cell biology professor of mine used to use this picture as an allegory of science: when we look at the pic, we're not seeing the camels, we're seeing the shadow of the camels. We do the same when we do an immuno, a western, or we measure the transcriptome.

Microscopy image showing different type of neurons labeled in green, red and purple in a section of mouse brain in the frontal cortex

For #FluorescenceFriday, activity-trapping experiments to better understand how amphetamine controls attention. RNAscope for glutamate neurons 🟢, inhibitory neurons 🔴 and our "ensemble" 🟣. Quotes for the loaded definition ;)

Image credit to JHU neuro student Suhaas Adiraju 🧠🔬🧪