Laura White

"are you enjoying duo mobile" does a hamburger enjoy being made of quarks. does a fish enjoy linear time. does the mountain enjoy the first taste of a cup of hot chocolate when you get back to the ski lodge. your question means nothing to me. i couldn't enjoy duo mobile even if i tried

Please help! We are looking for tissue-specific RNA-seq datasets or pubs with both male and female individual gene expression data, not pooled, from animal species. If you know of any relevant resources, please drop a link in the comments or send me a DM. Also, please help spread the word - thanks!

The future is not in the training set.

We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.

1/n

Wild.

My hand holding a shortbread cookie in the shape of an airplane. There are red sprinkles in the pattern of the survivorship bias plane.

A plate of the same cookies.

Does anyone want a survivorship bias shortbread

A small yellow brown dog on a couch looks very sad. Not because he doesn’t smell like dead squirrel (though he wishes he did), just because he isn’t being petted continuously until the end of time.

On Saturday my dog decided to roll in a dead squirrel so we had to bathe him and he has not smelled like himself for DAYS and I don’t know which of us this bothers more so thank you from both of us for the reminder to go look up fragrance free dog shampoo for this poor boy

Battling Infectious Diseases in the 20th Century: The Impact of Vaccines The number of infected people, measured over 70-some years and across all 50 states and the District of Columbia, generally declined after vaccines were introduced.

I have posted about this before, but...

Researchers at Pitt School of Public Health (with NIH funding) developed Project Tycho where they digitized reportable disease data from across the country going back to ~1900.

graphics.wsj.com/infectious-d...

1/6

🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)

Hello, do you have a moment to hear the good word about Huītzilōpōchtli?

Stop the nonsense: Prime editing generation of suppressor tRNA that overcome harmful effects of ‘nonsense’ gene variants — a possible remedy for a range of diseases @nature.com @harvard.edu @broadinstitute.org @stevenerwood.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...

Introducing the 𝐏𝐈-𝐚𝐭-𝐜𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐒𝐥𝐚𝐜𝐤 𝐦𝐨𝐝𝐞! 🤯

When activated, it will auto-reply to your PI's frantic ideas for new experiments, analyses, and projects with "Great suggestion! Saving this for later" (aka: let's talk when you’re back and got some sleep)

#sfn2025 #sfn25

we call that "taking it to your lair"

the actual location of the lair varies

Latest #CDlab paper on nanopore protein sequencing on @biorxivpreprint.bsky.social: www.biorxiv.org/cgi/content/...

Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!

When plotting, LLMs see what they expect to see - Posit Data science agents need to accurately read plots even when the content contradicts their expectations. Our testing shows today's LLMs still struggle here.

To be effective, data science agents need to be able to read plots reliably. @sara-altman.bsky.social and I wrote about some concerning findings on LLMs' ability to interpret plots when the content contradicts their expectations on the @posit.co blog.

posit.co/blog/introdu...

A leafless tree against a dark sky suffused with pink and green.

Aurora from Rocky Mountain Arsenal tonight.

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

Pictures of the plant, the seeds, the Bontebok, an antelope that makes the real dung, and the dung beetle.

Rare Earth will be back on air soon & in preparation for a programme on Darwin, Wallace & evolution, I found this ace example of evolutionary adaptation. The plant C. argenteum makes seeds that look & smell like dung, so dung beetles roll them away, bury them, then lose interest. Free seed planting!

We live in a tumultuous world. But I take solace in the fact that the 2010 University of Alaska Fairbanks hockey intro video remains the most unhinged thing I’ve ever seen.

Home Alone Great Showdowns

Life Aquatic Great Showdowns

Scott Pilgrim Great Showdowns

Lost Boys Great Showdowns

Scott Campbell (character designer for Psychonauts) does this ongoing series called Great Showdowns and puts 'em up for sale. He posted this Happy Death Day one today.

I have a ton waiting for frames.

Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing modifications to support...

How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)

Just sent @foodbankrockies.bsky.social the same amount we’d spend on a really nice dinner out to help with the coming SNAP cliff.

A graph showing the range of ear shapes in ring-tailed lemurs, with photos of lemur heads distributed over X/Y axes. The horizontal axis range has "round" ears on the left and "elf" ears on the right. The vertical axis range has "cat" ears at the top and "airplane" ears at the bottom. Graphic created by Abby Flyer

If you've been wondering how to tell ring-tailed lemurs apart, Duke Lemur Center has a very wonderful graph mapping individual variations based on ear angle and pointiness

Pointiness range is Round to Elf
Angle range is Cat (straight up) to Airplane (side-to-side)

lemur.duke.edu/catta-ears/ 🧪

A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.

Careers | Arcadia Science Evolve with Arcadia.

We have a bunch of new job ads out @arcadiascience.com. If you haven’t checked them out, take a look!

www.arcadiascience.com/careers

I know the term from audio encoding, where the idea is that you’re compressing files without losing information. Declaring losslessness at the *molecular* level feels like saying you could break each song on an album down to a count of notes without losing information.

Admittedly, I sequence stuff.

Destruction? What destruction? This is a lossless molecular zip algorithm working perfectly! 💥

("lossless," they say, blowing the molecules up and then cataloging the pieces with this incredibly useful technique)

this is both clever and I object

Even if you don’t escape the brain damage this one is worth it.