Amanda Klingler

Welcome to Save The U.S. National Science Foundation A Girl Looking at a Physics Model TAKE ACTION Save NSF is a coalition of concerned scientists and allies who are working to save funding for scientific grants through the U.S. National Science Foundation. Our mission is to support and advocate for the continuation of vital research and innovation in various scientific fields. NSF funding is critical to this work. Join us in our endeavor to ensure a sustainable future for scientific exploration and discovery.

I am so heartened to this seriously AWESOME #SaveNSF website go up today!!!!

Has a take action toolkit with:

1. Press outreach templates
2. Social media toolkit
3. Elected official outreach
4. Talking points

Check it out and share widely!!!! Likely more to come.

www.savensf.com

A tricky thing about modern society is that no one has any idea when they don’t die.

Like, the number of lives saved by controlling air pollution in America is probably over 200,000 per year, but the number of people who think their life was saved by controlling air pollution is zero.

Normalized and Directional Interplay Scoring for the Interrogation of Proteoform Data Histone proteoforms, often presenting multiple co-occurring post-translational modifications (PTMs), are central to chromatin regulation and gene expression. A proteoform is a specific form of a protein that includes variations arising from genetic changes, alternative RNA splicing, proteolytic processing, and PTMs. Genome-indexed histone proteoforms define the histone code, influencing cellular phenotype by dictating DNA interacting partners. Understanding the dynamics of histone proteoforms is essential for elucidating chromatin-based regulatory mechanisms. Advances in middle-down and top-down proteomics enable accurate identification and quantitation of thousands of proteoforms in a single run. However, the resulting data complexity presents significant challenges for analysis and visualization. Here, we introduce two new computational methods to analyze the dynamics of histone PTMs and demonstrate their use in mouse organs during aging. The score that we term “normalized interplay” addresses limitations of the original crosstalk score “interplay” providing a more complete and accurate measure of PTM crosstalk. The second score, ΔI or “directional interplay” is an asymmetric measure quantifying the magnitude and directionality of crosstalk between PTMs. Applying our two-stage scoring approach to data from CrosstalkDB reveals the dynamics of histone H3 modifications during aging.

I’m excited to share that my first scientific research article has been published: pubs.acs.org/doi/10.1021/...

If someone had told my younger self that I would one day contribute to math-heavy scientific research, I would have found it hard to believe!

“It is so disrespectful for Zelenskyy to not wear a suit in the White House.”

Accessibility Is Taking a Hit Across the Sciences Confusion has ensued about the future of programs and research supporting people with disabilities as a result of President Trump’s executive order.

www.nytimes.com/2025/02/22/s...

Featuring a quote from yours truly! Thank you for the opportunity to chat about accessibility in STEM during these trying times! #DisabledInSTEM

Please feel free to distribute this information widely to anyone you think could benefit and contribute any knowledge or tips you have to this thread! I am not an expert, just a concerned educator doing my best.

Please note that administrative and DHS warrants are not sufficient to override FERPA!

Second, I recommend printing a copy of your institution's FERPA quick guide to have on hand. If you are questioned about one of your students, you can reference/provide the FERPA document which outlines all the information we cannot legally disclose about a student absent a valid judicial warrant.

There is also a statement that can be read or handed to an ICE agent. I have been printing these to have in my office, on my person, and delivering them around my campus to high-traffic buildings and relevant offices.

www.ilrc.org/red-cards-ta...

A resource I recommend are the "Red Cards" or "Know your rights" cards produced by the Immigrant Legal Resource Center. They have printable PDFs in many languages that when printed and cut make small wallet-sized cards that outline the rights people can exercise when approached by ICE.

Attention all educators, keep reading for resources I have put together in light of the incoming immigration enforcement and the repeal of the sensitive locations policy (which previously prohibited ICE agents from conducting these activities in schools, hospitals, and churches)

Elon just did this…

Hey all! I'm a teaching professor of biology, science writing consultant, and academic disability advocate. I am here after deleting Twitter looking to rebuild a community. Elon musk once called me a woke meat computer, let's be friends.