Frédéric Guillaume's Avatar

Frédéric Guillaume

@fredguillaume.bsky.social

Evolutionary Biologist | Prof | Head of Department | University of Helsinki | Finland | Developer of Nemo Loves bugs when they crawl in a pot of flour. Hate bugs when they cripple my code.

16 Followers  |  32 Following  |  5 Posts  |  Joined: 10.02.2025  |  1.447

Latest posts by fredguillaume.bsky.social on Bluesky

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lesson #1 bsky doesn't like PNG files with a transparent background!!!
reposting it here

10.12.2025 10:15 — 👍 0    🔁 0    💬 0    📌 0

Contrary to usual expectation of stronger stabilising selection on central, more connected genes in gene expression networks, we found that hub genes responded more to selection. Hub genes were under stronger indirect selection than non hub genes and showed stronger signals of selection at SNP level

10.12.2025 10:06 — 👍 1    🔁 0    💬 0    📌 0
Fig. 2 in the paper showing the importance of indirect selection in driving the evolution of gene expression after 20 generations of evolution in a hot and dry environment. A: Gene expression evolves in the direction predicted in generation 1. B: The magnitude of evolutionary change in expression was also well predicted by estimates of genetic selection. C: Indirect selection dominates direct selection in genetic selection. D: Distribution of genetic selection coefficients (from Robertson & Price equation) in the Hot-Dry and the Control conditions at generation 1.

Fig. 2 in the paper showing the importance of indirect selection in driving the evolution of gene expression after 20 generations of evolution in a hot and dry environment. A: Gene expression evolves in the direction predicted in generation 1. B: The magnitude of evolutionary change in expression was also well predicted by estimates of genetic selection. C: Indirect selection dominates direct selection in genetic selection. D: Distribution of genetic selection coefficients (from Robertson & Price equation) in the Hot-Dry and the Control conditions at generation 1.

The quantitative genetics approach allowed us to predict evolutionary changes in gene expression at the whole transcriptome level.

With experimental evolution of replicated lines in a stressful hot and dry environment, we could verify that gene expression evolved as predicted after 20 generations.

10.12.2025 10:06 — 👍 2    🔁 0    💬 2    📌 0
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Gene expression evolution is predicted by stronger indirect selection at more pleiotropic genes Abstract. Changes in gene expression levels are central to adaptation, yet predicting and understanding their evolution remains challenging. Here, we used

How does gene expression evolve during adaptation? We used experimental evolution in beetles 🪲 to find out.

Using a joint transcriptomic and quantitative genetics approach, we show adaptation is driven by indirect selection on hub genes. #evolution #genetics
academic.oup.com/evlett/artic...

10.12.2025 10:06 — 👍 2    🔁 0    💬 1    📌 0

Hi there! Finally joining the #evolution #ecology #ecoevo tribe in here 🙂 Clearly missing some followers here, so hit me up!
Looking forward to being part of the discussion. Let's get started!

10.12.2025 09:48 — 👍 2    🔁 0    💬 0    📌 0

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