Andrzej Kierzek

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Very interesting paper. Proteosomes generate anti-microbial peptides in response to infection. It may well be previously unknown mechanism of innate immunity and source of new antibiotics. www.nature.com/articles/s41...

06.03.2025 06:26 — 👍 2    🔁 0    💬 0    📌 0

Yes, I can see possibility for some, but perhaps not in the rain 🙂. Also, for some it may be possible for me with tools, but impossible to rock climb. Finger to weight ratio is my weakness.

28.01.2025 12:56 — 👍 1    🔁 0    💬 1    📌 0

Will Nigel & Elon now propose that UK leaves Solar System? For far too long this country was under the pull of the same Sun that one hour earlier rises over Brussels!

17.12.2024 15:10 — 👍 0    🔁 0    💬 0    📌 0

Great news! Photos are taken under blue sky (no pun intended) which is rare occurrance in mid-Wales. Did they have to wait for a good day to run this test? Does it work in normal Welsh conditions. I hope it does, we need it and yes we should share it with people who defend all of us in Europe.

11.12.2024 13:54 — 👍 0    🔁 0    💬 0    📌 0

Ironically, the only rock climbing discipline which is not affected by rain is called dry tooling. Enjoyed dry tooling in the rain in Masson Lees quarry above Matlock (photo from session a year ago) this Sunday. #climbing

03.12.2024 17:51 — 👍 4    🔁 0    💬 3    📌 0

I don't think she should have resigned over this. Standards of politics must be high, but this is exaggeration.

29.11.2024 07:46 — 👍 1    🔁 0    💬 0    📌 0

I wish I could go there again for water ice climbing and utter beauty of crispy sunny winter. Did not happen this year again. Maybe one day, hopefully before winter dissapears over there too.

22.11.2024 12:44 — 👍 2    🔁 0    💬 0    📌 0

NEWS: Jessy Pilz climbs Papichulo 9a+ Jessy Pilz has made the second female ascent of Papichulo, 9a+, in Oliana, Spain.

Taking rest after Olympic season?https://www.ukclimbing.com/news/2024/11/jessy_pilz_climbs_papichulo_9a+-73848

21.11.2024 13:52 — 👍 0    🔁 0    💬 0    📌 0

Something that's been bugging me for a while in bioinformatics data analysis is this overreliance on packages, workflows and what's been called "cargo cult science".

Can we have more conceptual thinking, more theory?
Asking for what we really want to achieve and what we need to do gets us there.

19.11.2024 10:58 — 👍 223    🔁 34    💬 33    📌 1

Opening winter climbing season in my Lockdown Memorial Climbing Center. Hope to find winter in Cairngorms when I'm there for my usual February visit and use skills again on a wee bit longer climbs.

19.11.2024 14:28 — 👍 0    🔁 0    💬 0    📌 0

Brilliant! Thank you for that!

18.11.2024 08:20 — 👍 0    🔁 0    💬 0    📌 0

Welcome to BlueSky. It was good to climb on my local Millstone crag last week. I would not mind a bit bluer sky, and a bit dryer rock, but it was still good, espcially now that I can crack climb.

17.11.2024 14:54 — 👍 3    🔁 0    💬 0    📌 0