Yolanda Perez

Nobel Week is once again upon us! How many women and how many scientists from the Global South will be awarded Prizes this year? Remember that this is typically a set of Prizes dominated by white men from North America (some Europe, some Asia). The first announcement was today: Medicine. 🧵 1/

Yes, I completely agree. In the past, I generated several sequences, and implementation in the NMR spectrometer was straightforward.

¿Has obtenido una JAE INTRO CSIC 2025 y estás buscando un proyecto?
Echa un vistazo a nuestro plan de formación JAEINT25_EX_0767 en el IQAC-CSIC de Barcelona. Escríbeme si estás interesado y necesitas más información.
@dpe-csic.bsky.social

The 2024 Nobel Prize in Chemistry was awarded to David Baker for computational protein design and to Demis Hassabis and John M. Jumper for protein structure prediction. Proteins are important biological molecules formed from 20 naturally occurring amino acids. Proteins form folded 3D structures which are key to their function and properties, but the exact way in which they fold is hard to predict. In 2020, Demis Hassabis, John Jumper and their co-workers unveiled an artificial intelligence model called AlphaFold2 to predict 3D folded structures of proteins. David Baker developed Rosetta, software that also attempts to predict protein structures, and used it to start with a protein structure and use the software to work out its amino acid sequence. Predicting and designing protein structures benefits the design of protein-based drugs, sensors, vaccines, catalysts, and more. It also aids our understanding of existing proteins and how they interact with other molecules.

With the 2025 Nobel Prize in Chemistry being announced tomorrow, here's a reminder of the research on protein structure prediction that won last year's prize: www.compoundchem.com/2024/10/10/2...

#ChemSky 🧪

“Excellence R Us”: university research and the fetishisation of excellence - Humanities and Social Sciences Communications Humanities and Social Sciences Communications - “Excellence R Us”: university research and the fetishisation of excellence

You might enjoy our take on this www.nature.com/articles/pal...

Here are some reminiscences Jim wrote of NMR community in 1970s. https://www.nmrdg.org.uk/History_of_the_NMR-DG/Chairmen_files/Feeney.pdf

Sorry to hear Jim Feeney died at weekend. Born 1936 in St Helens, Jim graduated from Liverpool Uni also did PhD and was a lecturer there for 5 yrs. In 1972 he came to NIMR Mill Hill, was Head of Molec Struct Divn and controller of Biomed NMR Centre. Thks Jon Marsh for info.

NMR tube thickness and signal-to-noise ratio u-of-o-nmr-facility.blogspot.com/2012/12/nmr-... #nmr #nmrchat #chemsky

New technique to speed up the design of drugs targeting proteins in the cell membrane - Quadram Institute An team has developed a new technique that will speed up the design of drugs targeting ion channels, a type of cell membrane protein

“We believe our method could become a standard tool for structure-activity studies, and help understand how the chemical structure of a molecule relates to its pharmacological effect."

💬 Dr Serena Monaco

For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

'Innovation does not occur in a vacuum. It requires raw materials: the findings of basic research. We are currently burning through a stockpile of knowledge accumulated during a more enlightened era of public investment, while allocating insufficient resources for replenishing it.'

This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 2/31
Prompt WEAVE

N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms.

Pdb: 3UA0

Next prompt is CROWN and I would love your suggestions!

A Novel HMBC-CC-HMQC NMR Strategy for Methyl Assignment Using Triple-13C-Labeled α-Ketoisovalerate Integrated with UCBShift 2.0 In this study, we describe an integrated approach for methyl group assignment comprising precursor-based selective methyl group labeling, a novel puls…

📢 New paper: a combination of a new isotope labelling with solution-NMR, allowing to assign methyl groups even in large proteins -- we've tested it with our favourite ~130 kDa enzyme and a 70 kDa receptor.
->see thread
1/n
@istaresearch.bsky.social @univie.ac.at
www.sciencedirect.com/science/arti...

Supramolecular NMR contact shifts in paramagnetic cocrystals by @mareklab.bsky.social just published in Chemical Science: doi.org/10.1039/D5SC...

Séptimo límite

La salud del océanos es básica para nuestra estabilidad, y aunque estamos al borde del colapso, también estamos a tiempo de evitarlo. La viñeta de esta semana de @atxe.bsky.social en @climatica.coop https://climatica.coop/septimo-limite/

Join us in Brussels for the 7th Instruct Biennial Structural Biology Conference!

#IBSBC2026 showcases the latest in integrative structural biology from leading scientists across the world. This year's conference will take place 27-29 May - register below!

instruct-eric.org/ibsbc2026

an extraordinary person with an extraordinary legacy who nevertheless didn’t take herself too seriously

when Gary Larson published this cartoon, she was in Africa and her institute was horribly offended and drafted a complaint

the whole thing was defused when she returned - she found it funny

"What you do makes a difference, and you have to decide what kind of difference you want to make"

AlphaFold-Multimer accurately captures interactions and dynamics of intrinsically disordered protein regions | PNAS Interactions mediated by intrinsically disordered protein regions (IDRs) pose formidable challenges in structural characterization. IDRs are highly...

"AlphaFold-Multimer’s prediction accuracy is sensitive to the defined boundaries of the interacting partners" #alphafold

yep

www.pnas.org/doi/10.1073/...

Applications are now open for the position of Senior Research Laboratory Technician at the Autonomous University of Barcelona's Nuclear Magnetic Resonance Service (deadline 09/10/2025). Experience of NMR/MRI and an animal handling certificate are required.
#NMRchat #MRI #NMR

InNMR: an innovative NMR-tube insert enables direct studies of transport phenomena in situ A novel discoid insert together with a plunger tool has been developed that can be inserted into a standard NMR tube. By attaching any type of semi-permeable barrier to the bottom of the insert, the d...

Frison A, Sørensen MM, Prince K, Aachmann FL, Flaten GE, Rainsford P, et al. InNMR: an innovative NMR-tube insert enables direct studies of transport phenomena in situ. ChemRxiv. 2025; doi:10.26434/chemrxiv-2025-mzpv4
#NMR #NMRchat

If you rising senior PhD student and are interested to come to Europe as a postdoc, get in contact with PIs early (6-9 months ahead of time) and discuss postdoc funding options like fellowships

Synthetic Production of Penicillin Professor Alexander Fleming, holder of the Chair of Bacteriology at London University, who first discovered the mould Penicillin Notatum. Here in his laboratory at St Mary's, Paddington, London (1943). This photograph TR 1468 comes from the collections of the Imperial War Museums.

It's the anniversary of Alexander Fleming returning from summer break & finding his Staph. aureus culture plate had been left open with mold growing on it that killed bacteria.

Let's focus on what came next: how do we go from an agar plate in 1928 to 2.3 million doses ready on D-Day, June 1944?

So excited that our lab's first home-grown paper is now available on ChemRxiv!

Kinetic NMR screening: rapidly quantifying fast ligand dissociation in fragment mixtures using ¹⁹F relaxation dispersion | doi.org/10.26434/che... 🧲🧪

Virtual course Chemicals in a biological context: metabolites, drugs, and beyond EMBL-EBI resources in practice. 13 November 2025. Virtual. EMBL-EBI logo.

Join us on 13 November for our six-hour virtual workshop dedicated to using @ebi.embl.org resources in practice.

'Chemicals in a biological context: metabolites, drugs, and beyond' will show you how to use ChEMBL, MetaboLights, and PDBe.

Registration is £45.00: www.ebi.ac.uk/training/eve...

🧬🖥️🧪⚗️

Optimized shaped pulses for 2D-SIFTER Abstract. Fast and accurate arbitrary waveform generators (AWG) for generating shaped pulses in EPR have been commercially available for over a decade now. However, while the use of chirp pulses as in...

Please head over to Magnetic Resonance, lots of papers of interest and this one is open for discussion: mr.copernicus.org/preprints/mr... Thanks!

Registration is still available, closing October 7 #NMRchat 🧲

Functional spectrum of USP7 pathogenic variants in Hao–Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation | PNAS Hao–Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7)...

Our latest paper is online today ahead of print in PNAS
@pnas.org

www.pnas.org/doi/10.1073/...

#NMRchat 🧲

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This keeps it a free and open platform by design, leading to better click-throughs and traffic to your site.

We 💙 the open web.