Yolanda Perez

Liberalismo científico, o el extraño caso del doctor Jekyll y el señor Grant La investigación, como tópico de entretenimiento, siempre es una buena inversión para periódicos, películas e informativos de radio y televisión: toca temas curiosos o sensibles, luce tecnología, fome...

Liberalismo científico, o el extraño caso del doctor Jekyll y el señor Grant www.jotdown.es/2025/11/libe...

Oops. Ooooooooooooops.

I do hope that nobody has been given or denied a job/promotion based on their SpringerNature citation counts in the past 15 years.

arxiv.org/pdf/2511.01675

h/t @nathlarigaldie.bsky.social

Bro boost: women say their LinkedIn traffic increases if they pretend to be men Collective experiment found switching profile to ‘male’ and ‘bro-coding’ text led to big increase in reach, though site denies favouring posts by men

Earlier this year Jane Evans ran an informal LinkedIn experiment: 2 women & 2 men, posted identical content at the same time. The women had a combined 154K followers, the men had only 9,389. Guess who got the highest reach? Yep, the men.
www.theguardian.com/technology/2...

This team are searching for new "Asgard archaea" to sequence.

Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.

Once considered a type of oddball bacteria🦠...

#research #hydrogenbonding

NMR spectroscopy studies of hydrogen bonding
(Dračínský) – Coord. Chem. Rev.: doi.org/10.1016/j.cc...

@iocbprague.bsky.social @czechacademy.bsky.social

I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes

New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!

Even a Single Bacterial Cell Can Sense the Seasons Changing | Quanta Magazine Though they live only a few hours before dividing, bacteria can anticipate the approach of cold weather and prepare for it. The discovery suggests that seasonal tracking is fundamental to life.

Brrrr! Bacterial cells “bundle up” for winter, turning on a set of seasonal genes that changes the molecular composition of their cell membranes.🧣

My uni and many others have tried to centralize and automate many administrative functions. What happens is that the expertise is moved out of the department and then the rest of us suckers are left to learn to become admins and deal with all the edge cases. Such has been the last 6 yrs of my life

Analytical chemistry has become extremely automated in the last 25 years, and yet shit continues to break in new and befuddling ways that AI can’t possibly parse. The “datasets” for it to learn instrument repairs from exist in the minds of experts and are significantly vibes-based.

Lewis Kay on NMR’s Expanding Role in the Post–AlphaFold Era, from Eastern Analytical Symposium EAS 2025 www.spectroscopyonline.com/view/lewis-k... #NMRchat 🧲

New cutting-edge MRI and NMR equipments will arrive at the SeRMN-UAB, The Servei de Ressonància Magnètica Nuclear (SeRMN) at the Universitat Autònoma de Barcelona (UAB) sermn.uab.cat/2025/11/new-... #NMRnews #NMRchat 🧲

#NMRchat γ effects identify preferentially populated rotamers of CH2F groups: side-chain conformations of fluorinated valine analogues in a protein https://doi.org/10.5194/mr-6-257-2025

graphical abstract showing the combination of techniques used to analyze the dynamics of a de novo enzyme.

Our latest work is out! We combined #NMR with #Crystallography, #MD, and #ProteinMPNN to analyze the conformational dynamics of a de novo enzyme and redesigned it! Great collaboration between
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.

www.cell.com/structure/fu...

The nature extinction crisis is mirrored by one in our own bodies. Both have huge implications for health Modern life is waging a war against ecosystems around us and inside us. Keeping our own microbes healthy is another reason to demand action to preserve the natural world

The nature extinction crisis is mirrored by one in our own bodies. Both have huge implications for health

My quote of the day

In a world where everyone is behaving honestly, any dishonesty constitutes a big infraction. But, in a world where many people are behaving dishonestly, and the news is filled with stories of their infractions, even big infractions can feel small to the perpetrator.

Dan Ariely

The importance of getting away from your screen and talking to other people: The Sense of Community (with thanks to @andrewmaynard.net for stimulating this post) occamstypewriter.org/athenedonald...

Indeed, two decades ago now

Aptitude or attitude?: Lawrence Summers‘ recent remarks reflect what little progress has been made in the public's understanding of why women are under‐represented in science: EMBO reports: Vol 6, No ... EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

In case someone missed the 2005 discourse (it was 20 years ago, after all), the second bit (sadly) isn’t a joke.
www.embopress.org/doi/full/10....

Although the twentieth century finds male practitioners firmly in control of formal Western medicine, women doctors and healers still have important inventions and innovations to their credit. For example, although three men received the Nobel Prize for penicillin, women participated significantly in the team effort that brought the drug to medical usefulness. Women had discovered the mold’s usefulness centuries or perhaps millennia earlier (Halsbury 1971, p. 19; Raper 1952, p. 1), and one nineteenth-century Wisconsin woman, Elizabeth Stone, an early antibi otic therapist, specialized in treating lumberjacks’ wounds with poultices of moldy bread in warm milk or water: she never lost an injury patient (Stellman 1977, p. 87). In the twentieth-century development of the drug, it was a woman bacteriologist, Dr. Elizabeth McCoy of the University of Wisconsin, who created the ultraviolet-mutant strain of Penicillium used for all further production, since it yielded nine hundred times as much penicillin as Fleming’s strain (Bickel 1972, p. 185; O’Neill 1979, p. 219).4 And as Howard Florey, leader of the British penicillin team, was quick to point out, it was Dr. Ethel Florey’s precise clinical trials that transformed penicillin from a crude some time miracle worker into a reliable drug. It was also a woman, Nobel laureate and X-ray crystallographer Dr. Dorothy Crowfoot Hodgkin, who finally deter mined the precise structure of the elusive penicillin molecule (Bickel 1972, p. 216; Opfell 1978, pp. 211, 219). Women were also involved in developing the sulfa drugs that preceded penicillin. For instance, it was a married pair of chemists, Prof. and Mme. Tréfouėl, and their colleagues at the Pasteur Institute in Paris who split red azo dye to create sulfanilamide (Bickel 1972, p. 50). At least two women have invented new antibiotics for which they receive sole credit. Dr. Odette Shotwell of Denver, Colorado, came up with two new antibiotics—duramycin and azacolutin—during her fi…

reminder of cryptogyny, the hiding of women's contributions to science, technology, engineering, and medicine:
"although three men received the Nobel Prize for penicillin, women participated significantly in the team effort that brought the drug to medical usefulness."

www.jstor.org/stable/jj.55...

Don't miss Anagha Sasikumar, Radek Marek et al's recent article

#ChemSciCovers

'Supramolecular covalency of halogen bonds revealed by NMR contact shifts in paramagnetic cocrystals'

🔗 doi.org/10.1039/D5SC...

@mareklab.bsky.social

An enzyme gives atropisomers a specific twist Biocatalytic approach could be used to make chiral ligands and drugs

An enzyme gives atropisomers a specific twist

Biocatalytic approach could be used to make chiral ligands and drugs. cen.acs.org/synthesis/bi... #chemsky 🧪

Es que en lo son expertos es hacer trabajar a los demás… en su propio beneficio.

🔐 Account Security Thread 🔐
We're seeing an increased number of phishing and social engineering attempts targeting Bluesky users. While we're working hard to protect you, here are essential steps YOU can take to secure your account and stay safe. 1/10
🧵👇

Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1

Today’s Daily Cartoon, by Sarah Kempa. #NewYorkerCartoons

Integrative Structural Biology in the new Instruct-ES Center Madrid - January 29-30, 2026 - Instruct ERIC Spain

Instruct-ES Workshop, Integrative Structural Biology in the new Instruct-ES Center Madrid – January 29-30, 2026, at the IQF Blas Cabrera (CSIC) @iqf-csic.bsky.social @instruct-eric.bsky.social instruct-eric.es/2025/10/10/2... #NMRchat 🧲

Full-color image of the Cathedral of Barcelona, composed on a typewriter by Montserrat Alberich Escardívol. Image from WikiMedia.

Holy shit, just learned about the typewriter art of Montserrat Alberich Escardívol, a Catalan typist. Using an extra wide typewriter and 180 color ribbons, she built up elaborate images from simple characters like 'm' and '.' and ';'. Here is her typewritten painting of the Cathedral of Barcelona.

A deep dive on how chemical structure affects photochemical reactivity and defluorination pubs.acs.org/doi/10.1021/... Celebrating 25 years of photochemistry with @krismcneill.bsky.social and nearly 10 if NMR with @pomerantz.bsky.social @envirosci.acspublications.org

Fast and Reliable NMR-Based Fragment Scoring for Drug Discovery Fragment-Based Drug Discovery (FBDD) is a powerful strategy used in the development of new therapeutics. Molecular fragments are screened against a target protein, where interactions are typically characterized by a low affinity. Nuclear Magnetic Resonance (NMR) spectroscopy is well-suited to detect weak protein–ligand interactions and is therefore often used in FBDD. However, while NMR is very effective in initial screening, follow-up NMR experiments to measure binding affinities (i.e., KD values) are labor-intensive and time-consuming. To address this challenge, we have developed an innovative SHARPER NMR fragment scoring technique. The high sensitivity of SHARPER NMR dramatically reduces the data acquisition times, allowing faster and more accurate quantification of fragment KD values from ligand titration curves. To further accelerate fragment scoring, a machine learning model was developed that accurately ranks fragment affinities from only two SHARPER titration points. The resulting integrated method, termed “ML-boosted 1H LB SHARPER NMR”, produced significant time savings; using a 600 MHz QCI cryoprobe, KD values of up to 144 ligands in a day could be determined under our conditions, compared with only a handful achievable by traditional approaches. The proposed methodology will shorten the transition from hits to lead compounds, accelerating the drug discovery process by rapidly and reliably evaluating fragment binding, providing informed decision-making in the early stages of FBDD.

Nice paper just out from our NMR guys describing an accelerated method for measuring and scoring fragment binding affinities. pubs.acs.org/doi/10.1021/...