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Patrick Dolan

@ptdolan.bsky.social

Virologist, Evolutionary Biologist, IT guy, PI @ #QVEU big on mentorship, supporter of scientists. friendsofthelab.org Views expressed are my own. #DC

1,249 Followers  |  415 Following  |  49 Posts  |  Joined: 11.10.2023  |  2.0313

Latest posts by ptdolan.bsky.social on Bluesky

Some good news.

And on a Friday afternoon no less.

30.01.2026 21:09 β€” πŸ‘ 15    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

🚨 Requesting help:

I am looking for an agent who can facilitate more speaking gigs, podcast appearances, and interviews with journalists

I want to more widely share my story and expertise as a trans geneticist who understands the reality and complexity of "biological sex" πŸ³οΈβ€βš§οΈπŸ§¬

Please signal boost?

28.01.2026 21:03 β€” πŸ‘ 304    πŸ” 249    πŸ’¬ 15    πŸ“Œ 19
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We’re Hiring! β€” Verena The Verena Institute is looking for a full stack developer or full stack development team (hereafter, the β€œSupplier”) to assist with the maintenance, documentation, and development of the Pathogen H...

We're looking for a full-stack developer! Help us build the best open data platforms for pandemic prediction in the world.

Probably a short-term contract, but if you're looking for a full-time gig, let's talk. Inquire within: www.viralemergence.org/blog/were-hi...

17.01.2026 19:29 β€” πŸ‘ 9    πŸ” 12    πŸ’¬ 1    πŸ“Œ 0

I do love chicken, broccoli, and thing tacos.

14.01.2026 21:49 β€” πŸ‘ 11    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Registration deadline is fast approaching for the "Host adaptations to viral infections” Meeting May 10th-13th, 2026, at the CNRS Station Biologique de Roscoff, Brittany, France! JOIN US and the many amazing speakers! JOIN US!

sites.google.com/berkeley.edu...

14.01.2026 04:50 β€” πŸ‘ 18    πŸ” 14    πŸ’¬ 4    πŸ“Œ 2

Went to school for 20+ years. Just spent 30 minutes trying to assemble a door lock incorrectly because I didn’t realize β€œdn⬇️” was actually β€œβ¬†οΈup”.

10.01.2026 18:12 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Postdoc Position in Virology (1yr, renewable) We are launching M+RVL, a new research group dedicated to better understanding the
fundamental mechanisms of positive-strand RNA virus replication. Supported by the LabEx NetRNA
research cluster, the team is based within the Mosquito Models of Innate Immunity (M3I) unit at the
Institute of Molecular and Cellular Biology (IBMC) in Strasbourg, France. Strasbourg is a lively city in
northeastern France that offers a high quality of life, a vibrant university system, and a historic city center
at the heart of Europe.
Research Focus Replication organelles (ROs) are membrane-bound compartments that drive genome
replication in positive-strand RNA viruses. Mosquito-borne viruses must assemble ROs in both mosquito
and vertebrate hosts, which are separated by hundreds of millions of years of evolution. While structural
biology has revealed the architecture of ROs in human cells, structure alone cannot explain their
assembly, dynamics, and host-specific interactions, highlighting the need for integrative approaches.
To address this gap, M+RVL integrates high-throughput genetics, proteomics, and computational
modeling to dissect the mechanisms governing RO formation and function across hosts.
Research Leadership The group is led by William Bakhache, Ph.D.

Essential Skills: Strong background in virology, molecular biology, and biochemistry techniques.
Desired Experience: Experience handling BSL-3 pathogens; expertise in computational biology
(e.g., NGS analysis, proteomics data analysis, structural modeling).
How to Apply Please send a single PDF containing a cover letter (detailing past and future research
interests), a CV, and contact information for two references to williambakhache@hotmail.com.

Postdoc Position in Virology (1yr, renewable) We are launching M+RVL, a new research group dedicated to better understanding the fundamental mechanisms of positive-strand RNA virus replication. Supported by the LabEx NetRNA research cluster, the team is based within the Mosquito Models of Innate Immunity (M3I) unit at the Institute of Molecular and Cellular Biology (IBMC) in Strasbourg, France. Strasbourg is a lively city in northeastern France that offers a high quality of life, a vibrant university system, and a historic city center at the heart of Europe. Research Focus Replication organelles (ROs) are membrane-bound compartments that drive genome replication in positive-strand RNA viruses. Mosquito-borne viruses must assemble ROs in both mosquito and vertebrate hosts, which are separated by hundreds of millions of years of evolution. While structural biology has revealed the architecture of ROs in human cells, structure alone cannot explain their assembly, dynamics, and host-specific interactions, highlighting the need for integrative approaches. To address this gap, M+RVL integrates high-throughput genetics, proteomics, and computational modeling to dissect the mechanisms governing RO formation and function across hosts. Research Leadership The group is led by William Bakhache, Ph.D. Essential Skills: Strong background in virology, molecular biology, and biochemistry techniques. Desired Experience: Experience handling BSL-3 pathogens; expertise in computational biology (e.g., NGS analysis, proteomics data analysis, structural modeling). How to Apply Please send a single PDF containing a cover letter (detailing past and future research interests), a CV, and contact information for two references to williambakhache@hotmail.com.

Post-doc job alert! Please share with anyone who might be interested! @amersocvirology.bsky.social #virology #virosky #evolution

08.01.2026 22:56 β€” πŸ‘ 7    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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My first #QVEU postdoc, William @williambakhache.bsky.social is off to start his group at labex-netrna.cnrs.fr/presentation... in Strasbourg, FR. We’ll miss his leadership and friendship, but I’m so excited to see what he’s got planned. If you want to book a ticket on this rocketship, reach out! 🦠πŸ§ͺ

20.12.2025 01:05 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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My first #QVEU postdoc, William @williambakhache.bsky.social is off to start his group at labex-netrna.cnrs.fr/presentation... in Strasbourg, FR. We’ll miss his leadership and friendship, but I’m so excited to see what he’s got planned. If you want to book a ticket on this rocketship, reach out! 🦠πŸ§ͺ

20.12.2025 01:05 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

Open rank search in MB&B in the areas of computational biophysics & biochemistry (purely computational or mix of wet/dry lab). Review of applications begins on 1/2/2026.

27.11.2025 00:33 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Ilustration of evolution in ecological communities, feuturing Drosophila

Ilustration of evolution in ecological communities, feuturing Drosophila

PhD-position vacancy in Jan Hrcek's lab lab.hrcek.net, Czech Academy of Sciences: Exploring how rapid evolution in communities allows maintenance of genetic variation and species diversity. @erc.europa.eu πŸͺ° 🧬 🌏 πŸ§ͺApplication deadline: January 7th 2026

25.11.2025 12:41 β€” πŸ‘ 23    πŸ” 18    πŸ’¬ 0    πŸ“Œ 0

www.frontiersin.org/journals/mic...

Out now in its ultimate form! Congrats to NathÒnia and the rest of the team! 🦠 #virosky

19.11.2025 14:33 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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High-resolution mapping of a rapidly evolving complex trait reveals genotype-phenotype stability and an unpredictable genetic architecture of adaptation The extent to which adaptation can be predicted, particularly for traits with complex genetic bases, is unknown. Here, we leveraged a model complex trait, model species, and high-powered longitudinal ...

Thrilled to finally share the magnum opus of my PhD that focuses on the genetic basis of evolutionary change! Specifically, we know we can map the genetic basis of a trait, but can we tell which genes will underlie the trait shift when it evolves? doi.org/10.1101/2025...

18.11.2025 00:14 β€” πŸ‘ 64    πŸ” 30    πŸ’¬ 2    πŸ“Œ 3

Great to see this exciting perspective by young evolutionary biologists lead by the amazing @mbrasovives.bsky.social out!

14.11.2025 12:21 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

My department at UT Austin is looking to hire an Assistant Professor in Evolutionary Biology, broadly defined. Feel free to reach out to me with any questions you may have.
apply.interfolio.com/177547

13.11.2025 15:23 β€” πŸ‘ 47    πŸ” 71    πŸ’¬ 1    πŸ“Œ 2
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Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations - Nature Ecology & Evolution A search for analogues of the human SAMD9/9L antiviral genes identifies convergent evolution of this gene family in the bacterial and animal kingdoms, with species-specific and recent genomic signatur...

πŸ“–Latest from the lab:
Evo. characterization #antiviral #SAMD9/9L across #kingdomsπŸšΆβ€β™€οΈπŸ¦πŸ¦ πŸ§«πŸ–₯️: ancient #convergence + #adaptations @natecoevo.nature.com

Led by amazing Alexandre Legrand +major contributions by RΓ©mi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n

www.nature.com/articles/s41...

12.11.2025 17:55 β€” πŸ‘ 35    πŸ” 14    πŸ’¬ 2    πŸ“Œ 2

An empirical approach to evaluating the prevalence of long-lived balancing selection in humans--and important limitations. Work by @hannahmm.bsky.social

11.11.2025 19:14 β€” πŸ‘ 62    πŸ” 35    πŸ’¬ 0    πŸ“Œ 0
PhD advert

PhD advert

I recently moved my lab to Purdue University and am looking for graduate students. We are working at the interface of population genomics, quantitative genetics and functional genomics to understand how plants adapt to extreme environments. Reach out if you would like to discuss potential projects.

08.11.2025 15:42 β€” πŸ‘ 45    πŸ” 39    πŸ’¬ 1    πŸ“Œ 2
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Conrad Hal Waddington was born OTD in 1905.

His β€œepigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.

On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.

πŸ§ͺ πŸ¦«πŸ¦‹ πŸŒ±πŸ‹ #HistSTM #philsci #evobio

08.11.2025 16:03 β€” πŸ‘ 125    πŸ” 35    πŸ’¬ 5    πŸ“Œ 5

I want to do this PhD!!

07.11.2025 12:34 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Our new preprint is out πŸ₯³πŸ₯³πŸ₯³

Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?

πŸ‘‡

03.11.2025 12:26 β€” πŸ‘ 108    πŸ” 46    πŸ’¬ 3    πŸ“Œ 2

Making them question their assumptions… that the earth is older than 5000 years.

02.11.2025 03:56 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Brian, my student is recovering from the comments you made on their manuscript.

02.11.2025 03:52 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Also - need to acknowledge the big assist by @williambakhache.bsky.social for getting this project off the ground.

01.11.2025 19:57 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Jack also estimated how much evolutionary potential WNV E might have available for future adaptation, and compared our DMS data to natural diversity of flaviviruses to examine how well DMS data predicts evolution of related viruses. Very cool, comprehensive analysis!

01.11.2025 18:44 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Constraint in West Nile Virus Envelope Protein across Mosquito, Human, and Avian Host Cell Environments Abstract. Arthropod-borne viruses are a major cause of global viral infections, displaying evolutionary dynamics that differ significantly from vertebrate-

New in β€˜Virus Evolution’ from #QVEU! PhD student Jack Dorman used deep mutational scanning to measure evolutionary constraints on the Envelope protein of West Nile Virus in human, mosquito, and bird cell lines, doing a lot of work to put it into a structural context #VirEvol

01.11.2025 18:44 β€” πŸ‘ 23    πŸ” 6    πŸ’¬ 2    πŸ“Œ 0

National Guard giving out Halloween candy at the U street metro if you are interested!

31.10.2025 13:50 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Kid Koala - Moon River (Studio Version)
YouTube video by Periscope Kid Koala - Moon River (Studio Version)

youtu.be/Pp0U7SkYl2E

30.10.2025 16:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Did you go to Deltron in DC a couple weeks ago?

30.10.2025 13:58 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 3    πŸ“Œ 0

I’m not saying they won’t try to not pay us, but this isn’t confirmation of that.

Even in 2019 furlough was referred to as a type of β€œnon-pay status” by OPM. www.opm.gov/chcoc/transm...

30.10.2025 03:36 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

@ptdolan is following 20 prominent accounts