Institute for Protein Innovation

Axon Guidance: Explained In the late 19th century, neuroscientist Santiago Ramón y Cajal peered through a microscope at the spinal cords of three-day-old chick embryos and drew

Murky on the details of axon guidance? Start at the beginning 👀https://buff.ly/q9XhPpO

Axon Guidance Antibody Collection For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr

Axon guidance shapes how #neurons connect—and proteins like #Netrin-1, #DCC and #PUNC sit at the center of this process 🧠

IPI now offers #recombinantantibodies to all three targets, backed by solid validation data.
Explore our reagents: buff.ly/T1CktaD

IPI’s #yeastdisplay course is back by popular demand! Join us in June to learn the basics & hear directly from experts Dane Wittrup (@mitkochinstitute.bsky.social), @surgebiswas.bsky.social (Nabla Bio) & Justin Peruzzi (@aiproteins.com).

Applications are due on March 30! buff.ly/KmY7N86

We kicked off #SLAS2026 (@slasorg.bsky.social) by teaching a short course on automated liquid handling to some wonderful, engaged scientists and presenting our approaches to purification and integrated lab systems.

Still time to find us to share strategies, approaches, hot-takes, etc!

Hello from #SLAS2026 (@slasorg.bsky.social)! We shared automation tips as part of a liquid handling short course today, and we're excited to connect all week. Come find us!
👉 Feb 9-11: Posters on characterization, purification, integrated systems & more
👉 Feb 11: IPI talks automation ed w/ Opentrons

We’re bringing our five-day yeast display course back for 2026!

Last summer, 12 researchers from around the world joined IPI to learn the principles, applications and methods of #yeastdisplaytechnology — this year it could be you!

Apply to join us this June: buff.ly/IOLmxV2

Applications for IPI’s 2026 Yeast Display Technology for Antibody Discovery course are now open! Join us for 5 days this June to learn everything from library preparation and antigen biotinylation to MACS and FACS cell sorting.

Find out more: buff.ly/AFAVmuP

Synaptic cleft antibody collection Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft.  Proteins positione

Did you know @addgene.bsky.social now offers antibodies?

You can find 200+ #antibodies in their catalog — including IPI recombinants targeting #Netrin, #PUNC, #DCC, #Neurexin, #Neuroligin, #Glypican, #Integrin and more.

Browse here:

Good antibodies start with good data.

Our new anti-DCC, anti-Netrin-1, and anti-IGDCC3 (PUNC) #antibodies come with full validation datasets—including demonstrated lack of #crossreactivity.

Take a closer look: buff.ly/LLL78N2

IPI’s Haisun Zhu worked with the Chen Lab (@harvardmed.bsky.social @bostonchildrens.bsky.social) to pinpoint the role of the S2’ cleavage in the SARS-CoV-2 spike protein.

Their @natcomms.nature.com paper gives new details of pathogen entry that might guide future interventions ➡️ buff.ly/F9Xv2FJ

Applications are due TOMORROW for IPI’s Springer-Lu Postdoctoral Fellowship program. Apply now! buff.ly/BSjUH53

#proteinresearch #PhDJobs #postdocjobs #proteomics #proteinengineering #antibodyresearch

Come work with us! Apply this week for the IPI Springer-Lu Postdoctoral Fellowship in cell-surface protein research and antibody engineering.

Apply by Jan. 20! buff.ly/w6AKPdd

Machine learning enables efficient and effective affinity maturation of nanobodies Antibodies can bind their targets with exquisite potency and selectivity due in part to large antibody-target protein-protein interaction surface areas. Despite the ...

IPI teamed up with @deboramarks.bsky.social & Andrew Kruse @harvardmed.bsky.social to design optimized #nanobody binders using #ML on single-sort sequencing data. The approach could speed discovery by reducing the need for multi-sort #affinitymaturation.

Read more:

Addgene: Antibody Data Hub - IHC for Anti-Netrin-1 [IPI-NTN1.43] Data report for Anti-Netrin-1 [IPI-NTN1.43] antibody in Immunohistochemistry (Rat)

Localization in IHC for anti-Netrin-1 (from @samanthabutler.bsky.social @uclastemcell.bsky.social): buff.ly/8btHxg8

Addgene: Antibody Data Hub - IP for Anti-Netrin-1 [IPI-NTN1.43] in MCF7 culture medium Data report for Anti-Netrin-1 [IPI-NTN1.43] antibody in Immunoprecipitation (Human)

▶️ Immunoprecipitation performance for IPI anti-Netrin-1 (thanks to @ycharos.bsky.social): buff.ly/rm6DhLu

Addgene: Antibody Data Hub - ICC/IF for Anti-DCC [IPI-mDCC.114] in specificity assay Data report for Anti-DCC [IPI-mDCC.114] antibody in Immunocytochemistry (Mouse)

▶️ Immunofluorescence assays on IPI anti-DCCs, showing impressive target specificity: buff.ly/7RYySeU

Addgene: Antibody Data Hub - Flow Cytometry for Anti-IGDCC3 (PUNC) [IPI-mIGDCC3.13] Data report for Anti-IGDCC3 (PUNC) [IPI-mIGDCC3.13] antibody in Flow Cytometry (Mouse)

▶️ Here’s some flow cytometry data for IPI anti-IGDCC3 (PUNC), a target that’s low on available validated reagents: buff.ly/8J6x7hk

Axon Guidance Antibody Collection For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr

IPI has new #recombinant antibodies available against DCC, anti-Netrin-1 and anti-IGDCC3 (PUNC), key players in axon guidance!

Explore the datasheets and order here 👉 buff.ly/KYdEvur

Apply to the Springer-Lu Postdoctoral Fellowship to secure a place at IPI and 2+ years of funding to pursue ambitious research in #proteinresearch and #antibodyengineering.

Applications close in one week on Jan. 20: buff.ly/CCEOKjO

#PostDocJobs #PostDocPosition #PhDChat #ScienceJobs #STEMCareers

Institute for Protein Innovation - Director of Commercialization About IPI The Institute for Protein Innovation (IPI) is an independent nonprofit research institute dedicated to advancing protein science and accelerating biomedical discovery by developing and…

IPI is recruiting a new commercial director! This senior leadership role is a wonderful opportunity to help translate world-class protein science and technology into real-world impact.

Find out more: buff.ly/4OvJUnF

#sciencejobs #proteinscience #proteomics #commercialdirector #antibodyreagents 🧪

HMS MEDscienceWorks program graduates joined IPI at Emmanuel College this week to learn lab automation, assays and #Python-powered liquid handling. Training the #nextgen of #bioscientists is a big responsibility—one we’re excited to take on as we roll out new courses this year. More soon!

Applications to the IPI Springer-Lu Postdoctoral Fellowship are due on Jan. 20, 2026 — that’s two weeks away!

Apply now: buff.ly/Fp8rh51

Proteins positioned within the #synapticcleft govern #synapse formation, maintenance and #neurotransmission.

But the exact architecture of this space is still a mystery. IPI’s new #NRXN and #NLGN antibodies could help reveal the blueprint.

Order now: buff.ly/AtBazlt

As AI and machine learning capabilities expand, IPI is building nextgeneration Fab and VHH yeast display libraries to yield molecules with better developability. Our bioinformatics scientist Hoan Nguyen is central to this effort!

#bioinformatics #proteinscience #proteomics #AI

Lab coats off, holiday spirit on. 🎄✨

We’re wrapping up the year with the people who make our research possible. Cheers to a strong 2025 — and a bright year ahead!

New from the Mizuno Lab, with help from IPI’s Nirakar Basnet: insights into how #microtubule shoots stabilize and repair #axons — and how epothilone B drives CNS regeneration. Read it in Nature: buff.ly/lO9xwIX

🗓️Mark your calendars 🗓️ Applications for the IPI Springer-Lu Postdoctoral Fellowship are due in ONE MONTH.

Find out how to apply: buff.ly/2b45pWI

#neurojobs #sciencejobs #postdocjobs #proteinscience #proteinengineering

Glypican antibody collection Highly specific recombinant glypican (GPC) antibodies, validated for Flow cytometry and Immunofluorescence applications. Buy with Addgene!

IPI’s glypican antibodies are used in labs around the world to study neurodegenerative diseases, brain development, cancer biology and more — and our collection with @addgene.bsky.social just expanded 🤯

Order reliable recombinant antibodies targeting GPCs 1-6 on our website: buff.ly/QSwEnbQ

We’re excited to announce our plans for a course on antibody validation and characterization — and we need your help!

Fill out this survey to shape the course (it’s quick, we promise!) ➡️ buff.ly/KoyJfU9

IPI has launched a postdoc for scientists working in cell-surface protein research/antibody engineering — and we’ve expanded eligibility to include recent MD/PhD/MD-PhD grads + early-career postdocs!

Come work with us!

buff.ly/45QGcpW

#proteinscience #postdocjobs #neurojobs