Institute for Protein Innovation

Thanks Melody Wang & Samuel Mohler for joining us and a group of Emmanuel College students last week to share some of the exciting career paths that exist in the world of #labautomation. As #AI and automation take the lab by storm, there is still plenty of opportunity and room for innovation!

#IPISeminar next Tuesday ➡️ Charles Lee @jacksonlab.bsky.social will present on the identification and characterization of #structuralgenomicvariants using advanced technology platforms. Come join us! 1:30 p.m. ET in the Bray Room @harvardmed.bsky.social, or on Zoom! rb.gy/xcee9l

We had a great time last week teaching a talented group of Emmanuel College students the basics of #labautomation and #liquidhandling, inc #Opentrons T-2 & protocol design, Python & AI, copper sulfate & Bradford assays and more. Big thanks to our wonderful Automation Team & creative students!

Nice article from @xinruw.bsky.social & David Baker @uwproteindesign.bsky.social w/IPI cofounder Timothy Springer and others. They engineered a de novo #miniprotein, #NeoNectin, that could enhance cell attachment & spreading through binding with #integrin α5β1 ➡️

pubmed.ncbi.nlm.nih.gov/40489013/

Behind the scenes at IPI 🔬

Development of Mutant M3 Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins The M3 muscarinic acetylcholine (ACh) receptor (M3R), a prototypic class A biogenic amine G protein-coupled receptor (GPCR), regulates ...

An NIH team w/IPI cofounder Andrew Kruse developed mutant M3 receptors with distinct signaling preferences. These tools could help uncover how M3R signaling shapes physiology and inform next-gen therapeutics with fewer side effects.
pubs.acs.org/doi/abs/10.1...

IPI principal scientist Shaotong Zhu recently returned from presenting IPI’s antibody development efforts targeting the synaptic cleft at the Surfaceome Conference in Scanno, Italy—a fantastic gathering of neuroscientists investigating synapse formation, plasticity, and more!

CST's Commitment to Antibody Validation Through YCharOS CST publishes antibody testing data from YCharOS, an independent, third-party validation organization, to help ensure scientific reproducibility.

“We view the @ycharos.bsky.social platform not just as a methodology, but as a movement to echo our long-standing belief in robust, reproducible, scientific research.”

Great insights from @cellsignal.com, thanks for sharing!
blog.cellsignal.com/antibody-val...

Machining antibodies at IPI Very little these days escapes the reach of machine learning (ML) and, more broadly, artificial intelligence (AI). Antibodies have caught the AI train, as

What can we extract from our #antibody selection data? Certainly more — with #AI on our side. Read how IPI and collaborators @harvardmed.bsky.social applied #machinelearning and #artificialintelligence to streamline #antibodydiscovery for cell surface #antigens.
proteininnovation.org/2025/05/mach...

A @csisingapore.bsky.social team showed D-I-Tasser can outperform AlphaFold2/3, elevating high-accuracy protein structure & function predictions. We wonder if this moves us closer to resolving protein–protein complex structure prediction? @natbiotech.nature.com

www.nature.com/articles/s41...

Automation fun in the lab this month 🤖 🧪

IPI scientists take on PEGSummit 2025 It’s that time of year in Boston when the flowers bloom, the trees bud and the protein science community emerges from labs across the country to make the

Ever wonder what’s happening at the IPI bench? Here’s your chance to snoop! Take a look at what our scientists are up to, as presented at #PEGSummit last month 👀
proteininnovation.org/2025/05/ipi-...

Structural Features of Glypicans and Their Impact on Wnt Signaling in Cancer

In a recent review paper out of the NIH, Hsi-En Tsao and Mitchell Ho detail the modulatory role of #glypicans in #Wntsignaling & underscore the need for better blueprints of glypican/Wnt/Fzd complexes. Check out their mini review 📝 onlinelibrary.wiley.com/doi/full/10....

Cytiva | ÄKTA™ systems user day An event to explore how ÄKTA™ lab-scale protein purification systems deliver speed and flexibility in research and process development— enhancing your workflow and results.

IPI Senior Scientist Anita Ghosh will join a ‪@cytiva.bsky.social‬ miniconference at Pfizer tomorrow to discuss high throughput #proteinpurification and other advances. Registration is still open — find out more! 🧬🧶 #protein #proteinscience
info.cytivalifesciences.com/cambridge-ak...

During this episode, @fang-xie.bsky.social and I interview @cdbahl.com, co-founder and CEO of @aiproteins.com. We discuss with Chris his interest in protein science and how he started his academic lab at the @ipiproteins.bsky.social.

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications Intrabodies are engineered antibodies that function inside living cells, enabling therapeutic, diagnostic, and imaging applications. While powerful, their development has been hindered by challenges…

In a #preprint released earlier this year, a Colorado State University-based team successfully converted #antibodysequences into functional #scFvs — using an #AI-driven method that could ease #intrabody design & development. Take a look! #proteindesign 🧬🧶 www.biorxiv.org/content/10.1...

IPI Events Calendar Learn how Google Calendar helps you stay on top of your plans - at home, at work and everywhere in between.

Pengxiang Huang of @bcmhouston.bsky.social‬ joins us for our next #IPISeminar today at 2 p.m. EST to share work on #signaltransduction in the #Hedgehog & #Wnt pathways! Follow the QR Code below or find the Zoom link on our calendar ➡️ rb.gy/xcee9l #neuroskyence #proteinscience

A big thank you for the insights shared by our guest speakers: Andrew Kruse ‪@harvardmed.bsky.social‬, Dane Wittrup ‪@mitkochinstitute.bsky.social‬ and Jamie Spangler ‪@jhu.edu‬!

First yeast display course = complete ✅ We spent an impactful week exploring #yeastdisplay (library construction to FACS to NGS prep) with a curious, focused & thoughtful group.
Stay tuned—we’re just getting started! mailchi.mp/proteininnov...
#antibodydiscovery #proteinengineering

5th International Antibody Validation Meeting 5th International Antibody Validation Meeting

Deb Moshinsky, IPI’s characterization & validation expert, will join this year’s #Antibody Validation Meeting @uniofbath.bsky.social‬ this Sept 🧑‍🔬 Poster abstracts are due 6/30 & registration is open all summer. Come chat #Abvalidation best practices! #abval25
www.antibodyvalidation.co.uk

IPI scientists take on PEGSummit 2025 It’s that time of year in Boston when the flowers bloom, the trees bud and the protein science community emerges from labs across the country to make the

Holistic antibody discovery and bespoke production workflow. Specially crafted yeast display libraries and #AI wizardry. Read what IPI scientists had to share last month at the #PEGSummit!
proteininnovation.org/2025/05/ipi-...

Stay connected with IPI! Join our mailing list to receive updates on future yeast display and other IPI courses.

Sign up for education updates from IPI: mailchi.mp/proteininnov...

Our #yeastdisplay for #antibodydiscovery course is off to a great start here on the Emmanuel College campus, with talks from IPI senior platform director André Teixeira, IPI scientist Deepash Kothiwal and Angela Reslow of Miltenyi Biotec yesterday! More learning to come!

Machining antibodies at IPI Very little these days escapes the reach of machine learning (ML) and, more broadly, artificial intelligence (AI). Antibodies have caught the AI train, as

We’ve got data — an unprecedented amount of publicly available #antibodysequence data, in fact. Read how IPI & @harvardmed.bsky.social collaborators used AI/ML to pull out new insights, then see what you might find in the haystack 🔍🌾
proteininnovation.org/2025/05/mach...

This paper changed my life Neuroscientists respond to a set of questions to reflect on a paper that profoundly influenced their career and how they think about their research.

How much impact can a paper have? Turns out, a lot. Take a look @thetransmitter.bsky.social‬’s “This paper changed my life” & show your favorite papers some love! www.thetransmitter.org/this-paper-c...

Stay connected with IPI! Join our mailing list to receive updates on future yeast display and other IPI courses.

We’re looking forward to sharing our knowledge on #yeastdisplay & #antibodydiscovery with 12 learners in our summer course next week! Sign up to our newsletter for the latest on #IPIeducation!
mailchi.mp/proteininnov...

IPI scientists take on PEGSummit 2025 It’s that time of year in Boston when the flowers bloom, the trees bud and the protein science community emerges from labs across the country to make the

It’s that time of year in Boston when the flowers bloom, the trees bud and the protein science community emerges from labs across the country to make the migration, long or short, to #PEGSummit. This year, IPI had plenty to add to the conversation. Read more! proteininnovation.org/2025/05/ipi-...

Machining antibodies at IPI Very little these days escapes the reach of machine learning (ML) and, more broadly, artificial intelligence (AI). Antibodies have caught the AI train, as

How to accelerate, discover, & streamline antibody development!

@ipiproteins.bsky.social & @harvardmed.bsky.social report a novel framework for making synthetic recombinant antibodies that can generate data specifically optimized for machine learning integration.

2025 CNCM Conference – UCI Center for Neural Circuit Mapping The 2025 summer conference on “The Changing Brain” (August 18-20, 2025), jointly sponsored by the CNCM, Cajal Club and Allen Institute for Brain Science, will be held at the Marriott Irvine (2.6…

IPI is happy to support the ‪@ucirvine.bsky.social‬ CNCM Changing Brain conference, a showcase of neural circuit studies in health and disease, genes, cell types, systems, disorders & more. Register by June 1! 🧠
cncm.som.uci.edu/2025-cncm-co...
#neuroskyence #neuralcircuits

Protein tools IPI is proud to provide high-quality, well-validated recombinant antibodies and other protein tools to the biological research community. We prioritize difficul

Working with #integrin or #glypican antibodies? Need a reliable plasmid or #antibody build to target #epitopetags? View our catalog and order IPI antibodies through @addgene today! proteininnovation.org/protein-reso...