David Calderwood

A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling Nerve growth factor (NGF) binding to the receptor tyrosine kinase, TrkA, drives neurotrophic signaling essential for neuronal development and survival. This interaction simultaneously drives periphera...

New preprint alert! biorxiv.org/content/10.1...
Nerve growth factor binding to TrkA helps neuronal growth and survival, but also triggers pain. This dual role has long complicated therapeutic targeting of this highly sought-after pathway in #Clinicaltrials for #chronicPain and #neurodegeneration.

A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels - Nature Biotechnology Epithelial organoids are grown without Matrigel using a single-chain antibody.

A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels
www.nature.com/articles/s41...

Flyer for Yale Pharmacology's 2025–2026 Alan C. Sartorelli Lecture, presented by Tobias Meyer, PhD. Dr. Meyer will be presenting his work at 4 pm on Thursday, October 16, 2025 in The Anlyan Center (TAC) N107, with a reception to follow from 5-6 pm. Dr. Meyer is the Joseph Hinsey Professor of Cell & Developmental Biology and Professor of Biochemistry & Biophysics at Weill Cornell Medicine. The title of his talk is "Both Structural and Signaling Polarity Mechanisms Direct Cell Migration."

Join us in welcoming our 2025-2026 Alan C. Sartorelli Lectureship speaker, Dr. Tobias Meyer. He will be presenting his work at 4 pm on Thursday, October 16th in The Anlyan Center.

How cells move and change shape—and why it matters for our health - News Inside each of your cells, there’s a microscopic scaffolding that helps determine what the cell looks like, how it moves, and how it responds to its surroundings. This internal structure, called the c...

How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding.
www.rockefeller.edu/news/38446-h...

Mechanochemical waves in focal adhesions during cell migration Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.

Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social

The integrin odyssey - a journey full of fundamental discoveries - PubMed Integrins are widely expressed cell adhesion receptors that link extracellular matrix proteins to the cytoskeleton. Most integrins connect to the actin cytoskeleton through different types of adhesion...

The integrin odyssey - a journey full of fundamental discoveries.
pubmed.ncbi.nlm.nih.gov/40988584/

Molecular exaptation by the integrin αI domain An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

📢 Attention #undergraduates, #gradstudents, and early-career #postdocs! Apply for JCB’s Alan Hall & Norton B. Gilula Travel Awards ✈️ that support your attendance at #CellBio2025 (Dec. 6-10) in Philadelphia! Apply by October 17 👉 rupress.org/jcb/pages/al...

@ascbiology.bsky.social

Excellent talk from Yossi Schlessinger at the ASBMB Meeting. He gave the Herbert Tabor Research Award Lecture to a capacity crowd.

Flyer for the Yale Pharmacology Seminar Series. This flyer indicates that Jim Collins, Ph.D. will be presenting his work at 12 pm on Thursday, April 17, 2025 in the Brady Auditorium. Dr. Collins is the Termeer Professor of Medical Engineering and Science and Professor of Biological Engineering at Massachusetts Institute of Technology and is a Founding Core Faculty Member of the Wyss Institute at Harvard University. The title of his talk is "Deep Learning for Antibiotic Discovery."

Join us in welcoming our next 2025 Pharmacology Seminar Series speaker, Jim Collins. He will be presenting his work at 12 pm on Thursday, April 17th in the Brady Auditorium.

congratulations Moi and team!

Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions This study presents a comprehensive atlas of protein and phosphoprotein turnover across 16 mouse tissues and brain regions using advanced proteomics and isotope labeling. It reveals tissue-specific pr...

Congratulations Yansheng and colleagues!
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: Cell www.cell.com/cell/fulltex...

Very sorry to hear about Mike's passing

‘Molecular library’ opens up new frontier of biological space-time A new platform from the Yale Nanobiology Institute provides access to numerous membrane proteins – key targets in the fight against resistant disease

Congrats to the Gupta lab and collaborators in the @moitrayee-lab.bsky.social, Yansheng Liu and Jim Rothman labs. bit.ly/proteinlibrary

Seminar announcement for Dr Alessi

It’s an honor to host Dario Alessi for our Department of Cell Biology seminar series tomorrow! #parkinsonsresearch

Today marks the beginning of OpenRxiv, which replaces bioRxiv and medRxiv, the world's largest preprint platform for life and medical science
openrxiv.org/introducing-...
@openrxiv.bsky.social

BBS-Wide Joint Cultural Foods Social Hour! This Friday :)

Great to see this work out Meaghan! Congratulations.

FDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain The FDA approved Journavx (suzetrigine) 50 mg oral tablets, a first-in-class non-opioid analgesic to treat moderate to severe acute pain in adults.

@fda.govFDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain www.fda.gov/news-events/...

Flyer for the Yale Pharmacology Seminar Series. This flyer indicates that Titus Boggon, Ph.D. will be presenting on Thursday, January 23, 2025 in the Brady Auditorium. The title of his talk is "Revisiting RasGAP: New insights from the first GTPase Activating Protein for Ras."

Titus Boggon will be speaking at the next seminar in our 2025 Pharmacology Seminar Series. Join us at 12 pm on Thursday, January 23 in the Brady Auditorium to hear about his exciting work.

Poster announcing Timothy Springer as the 2025 Tai-Shun Lin Memorial lecturer in Dept. Pharmacology, at Yale School of Medicine

Looking forward to Tim's Tai-Shun Lin Memorial lecture this afternoon

Graphical abstract of the Organelle Profiling paper, showing the workflow: Endogenously tagged organelle library; Native IP proteomics; Data-driven graph clustering; resulting in a subcellular proteome map with more than 7,600 proteins localized across 19 subcellular compartments.

Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/

1/3 🧪

PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!

thanks Mark