Samuele Laudani

Annual ISD Research Retreat 🎆 Great talks, project presentations, poster session, games, guest talks and an amazing LLM workshop by Rainer Malik 🙏

This is truly impressive work. Congratulations!

Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice Nature Microbiology - A multi-omics approach reveals host–microbiome interactions in aging in mice.

Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice rdcu.be/efio5

FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...

New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...

How the brain decides whether to persist — and when to give up Neuroscientists demonstrate how specific neurons in the brainstem control these behavioural strategies in mice.

How the brain decides whether to persist — and when to give up

www.nature.com/articles/d41...

Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation Wu et al. provide new insights into how aspartame consumption exacerbates atherosclerosis through an insulin-dependent mechanism. Aspartame-triggered high insulin levels upregulate the endothelial mem...

Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation: Cell Metabolism www.cell.com/cell-metabol...

The neuroimmune connectome in health and disease Nature - A review of studies on communication between the nervous and immune systems redefines the neuroimmune connectome with a focus on health and disease, and discusses how the latest techniques...

"The neuroimmune connectome in health and disease"
rdcu.be/d9Qmc

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice Intermittent fasting (IF) is generally associated with improved metabolism, but whether there are age-dependent limitations of IF needs to be explored. Matta et al. now demonstrate that while IF impro...

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice: Cell Reports www.cell.com/cell-reports...

Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses Zhu et al. employed multi-omics analysis to reveal critical links among the gut microbiome, the gut metabolome, and anti-PD-1/PD-L1 therapy response. Five distinct enterotypes with unique metabolic pr...

Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses: Cell Metabolism www.cell.com/cell-metabol...

This is figure 3, which shows city-level net changes in temperature-related excess death rates for each warming level under scenario SSP3-7.0 and no adaption to heat.

Temperature-related deaths in European cities could increase by up to 50% by the end of the century in the absence of climate change-mitigation policies, totalling up to 2.3 million additional deaths, suggests a paper published in Nature Medicine. https://go.nature.com/4glnYzU 🧪

Very interesting research! Congrats and thank you for sharing.

Early life microbial succession in the gut follows common patterns in humans across the globe Nature Communications - Here, the authors perform a global analysis of over 3000 infant gut samples revealing a universal pattern of microbial changes over the first 1.5 years, with declines in...

Super proud of this paper on infant gut microbiome age coming from my lab. The paper has just been published with @springernature.bsky.social in @naturecomms.bsky.social. Read about it here: rdcu.be/d6cCw.

Using clusterProfiler to characterize multiomics data - Nature Protocols clusterProfiler is a tool for characterizing and visualizing omics data. The example procedures show integration of metabolomics and metagenomics analyses, characterization of transcription factors an...

Using clusterProfiler to characterize multiomics data www.nature.com/articles/s41...

Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals - Nature Microbiology Using 21,561 individuals, the authors present a cross-sectional study of how gut microbiome signatures are associated with dietary intake patterns and with host health outcomes.

Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals
www.nature.com/articles/s41...

The host genotype actively shapes its microbiome across generations in laboratory mice - Microbiome Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass on microbial colonization to its offspring. However, the l...

The host genotype actively shapes its microbiome across generations in laboratory mice.

microbiomejournal.biomedcentral.com/articles/10....

Deconstructing the neural circuit underlying social hierarchy in mice Xin et al. find that in the dorsomedial prefrontal cortex (dmPFC), layer 2/3 neurons projecting to the anterior basolateral amygdala promote losing, whereas layer 5 neurons projecting to the dorsal raphe nucleus and periaqueductal gray promote winning. Moreover, the lose-related pathway inhibits the win-related pathways through local GABAergic interneurons.

Deconstructing the neural circuit underlying social hierarchy in mice www.cell.com/neuron/abstr... - how your brain tells you if you're winning or losing (if you're a mouse)

Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism - Communications Biology This study models early life stress (ELS) to observe sex-specific effects on fear memory formation using innovative unsupervised classification together with cellular metabolism alterations in key str...

We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing.
@mathiasvschmidt.bsky.social
nature.com/articles/s42...
Highlights in thread👇

Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer by Sasikumar Kotagiri, Nicholas Blazanin, @yonathanlissanu, and colleagues at @MDAndersonNews http://dlvr.it/TGvsrj

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...

Sidharth Madhavan, et al show ketone body β-hydroxybutyrate alters solubility of misfolded proteins, facilitating their removal & reducing pathological aggregation @buckinstitute.bsky.social @ucsfgeriatrics.bsky.social @ithacacollege.bsky.social @cellchembiol.bsky.social www.cell.com/cell-chemica...

20 years ago, #Akkermansia muciniphila was discovered 🦠🎈.

To celebrate two decades of science on this unique bacterium, we reviewed its role in the human gut, some special biological features and potential applications. t.co/UpIHJyIVoQ

#microbiology #microbiota

Large language models surpass human experts in predicting neuroscience results - Nature Human Behaviour Large language models (LLMs) can synthesize vast amounts of information. Luo et al. show that LLMs—especially BrainGPT, an LLM the authors tuned on the neuroscience literature—outperform experts in pr...

Large language models surpass human experts in predicting neuroscience results www.nature.com/articles/s41...

Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle - Nature Neuroscience Lüthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep. Stressful experiences during waki...

🔵 blue spot alert: Anita Luethi's team reports a dual role of #locuscoeruleus in #sleep in Nature Neuroscience @natureportfolio.bsky.social

1) high LC activity facilitates cortical microarousals
2) low LC activity is required for NREMS-to-REMS transitions

doi.org/10.1038/s415...

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.

www.science.org/doi/10.1126/...

Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts - Nature Microbiology Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.

Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
www.nature.com/articles/s41...

Like ‘old Twitter’: The scientific community finds a new home on Bluesky After recent changes to Elon Musk’s X, a gradual migration turns into a stampede

Like ‘old Twitter’: The scientific community finds a new home on Bluesky
www.science.org/content/arti...

“Bluesky seems to be the app where you post about being on Bluesky”

@jasonadamk.bsky.social for @newyorker.com