@tniethamer.bsky.social
Mom, scientist, Stadtman Investigator at NCI. Excited about 🫀endothelial cells in 🫁 lung development and regeneration. Views my own.
A beautifully written piece on a terrible time
www.science.org/content/arti...
Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases. 🧬🧠🔬🧪
21.07.2025 15:57 — 👍 8 🔁 3 💬 1 📌 1I am thinking a lot today about how heavy things feel in my world of faculty doing scientific research. There's the immediate chaos and panic about our ability to pay people and continue our research. But there's also a deeper grief at watching everything get bulldozed for no reason
15.05.2025 02:35 — 👍 1201 🔁 250 💬 24 📌 25
Peter Marks, MD, PhD Director, Center for Biologics Evaluation and Research U.S. Food and Drug Administration 10903 New Hampshire Avenue Silver Spring, MD 20903 March 28, 2025 Sara Brenner, MD, MPH Acting Commissioner of Food and Drugs U.S. Food and Drug Administration 10903 New Hampshire Avenue Silver Spring, MD 20903 Dear Dr. Brenner: It is with a heavy heart that I have decided to resign from FDA and retire from federal service as Director of the Center for Biologics Evaluation and Research effective April 5, 2025. I leave behind a staff of professionals who are undoubtedly the most devoted to protecting and promoting the public health of any group of people that I have encountered during my four decades working in the public and private sectors. I have always done my best to advocate for their well-being and I would ask that you do the same during this very difficult time during which their critical importance to the safety and security of our nation may be underappreciated. Over the past years I have been involved in enhancing the safety of our nation's blood supply, in advancing the field of cell and gene therapy, and in responding to public health emergencies. In the last of these, during the COVID-19 pandemic I had the privilege of watching the vision that I conceived for Operation Warp Speed in March 2020 in collaboration with Dr. Robert Kadlec become a reality under the leadership of HHS Secretary Azar and President Trump due to the unwavering commitment of public servants at FDA and elsewhere across the government. At FDA, the tireless efforts of staff across the agency resulted in remarkably expediting the development of vaccines against the virus, meeting the standards for quality, safety, and effectiveness expected by the American public. The vaccines undoubtedly markedly reduced morbidity and mortality from COVID-19 in the United States and elsewhere. Many of these same individuals applied learnings from the pandemic during a flawless response helping…
ongoing multistate measles outbreak that is particularly severe in Texas reminds us of what happens when confidence in well-established science underlying public health and well-being is undermined. Measles, which killed more than 100,000 unvaccinated children last year in Africa and Asia owing to pneumonitis and encephalitis caused by the virus, had been eliminated from our shores. The two-dose measles, mumps, rubella vaccine regimen (MMR) using over the past decades has a remarkably favorable benefit-risk profile. The MMR vaccine is 97% or more effective in preventing measles following the two-dose series, and its safety has been remarkably well studied. Though rarely followed by a single fever-related seizure, or very rarely by allergic reactions or blood clotting disorders, the vaccine very simply does not cause autism, nor is it associated with encephalitis or death. It does, however, protect against a potential devasting consequence of prior measles infection, subacute sclerosing panencephalitis (SSPE), which is an untreatable, relentlessly progressive neurologic disorder leading to death in about 1 in 10,000 individuals infected with measles. Undermining confidence in well-established vaccines that have met the high standards for quality, safety, and effectiveness that have been in place for decades at FDA is irresponsible, detrimental to public health, and a clear danger to our nation's health, safety. and security. In the years following the pandemic, at the Center for Biologics Evaluation and Research we have applied the same unwavering commitment to public health priorities to the development of cell and gene therapies to address both hereditary and acquired rare diseases. During my tenure as Center Director we have approved 22 gene therapies, including the first gene therapy ever to be approved in the United States. However, we know that we must do better to expedite the development of treatments for those individual suffering from any one of the thousan…
Peter Marks’s resignation letter. Everyone should read this.
29.03.2025 02:29 — 👍 619 🔁 337 💬 15 📌 33Dear all, Because of your help shining light on this all 15 were reinstated today. This is a huge win for science - When We Fight We Win!!!
13.03.2025 01:25 — 👍 635 🔁 128 💬 4 📌 4It's been a whirlwind of a month for me, but I want to take a moment to say I am so excited for this paper to be out! If you are interested in how the lung responds to injury and how it regenerates (or doesn't...) please go take a look! tinyurl.com/4r4zttkv
24.02.2025 21:16 — 👍 13 🔁 4 💬 1 📌 1MYRF is Essential in Mesothelial Cells to Promote Lung Development and Maturation https://www.biorxiv.org/content/10.1101/2025.02.13.635155v1
15.02.2025 00:31 — 👍 0 🔁 1 💬 0 📌 0I put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training
30.01.2025 15:10 — 👍 165 🔁 62 💬 5 📌 0Same on both counts 😂
26.11.2024 02:46 — 👍 0 🔁 0 💬 0 📌 0We are your neighbors and friends! ❤️
17.11.2024 15:38 — 👍 3 🔁 0 💬 0 📌 0
Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer https://www.biorxiv.org/content/10.1101/2024.11.13.623500v1
15.11.2024 23:49 — 👍 4 🔁 2 💬 0 📌 0
A close-up view of freshly-cooked shell pasta (Annie's white mac & cheese) with green peas (previously frozen). There are a smaller number of peas than shells, but each is nestled snuggly in a shell as if purposely stuffed
Strong receptor-ligand binding affinity
#ChemistsWhoCook
Waves of new BlueSky arrivals in last few days!
I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology
Hope it’s helpful but warning: now a v long thread!
Probably the last time I can do this...
Hello BlueSky! I'm a #newpi in #devbio at #NCI interested in how endothelial cells in blood vessels help build and repair tissues - can't wait to talk science with you all! 🫀🫁
13.11.2024 03:21 — 👍 9 🔁 1 💬 0 📌 0
