Kevin B Knopf

now Tom Lehrer - what a week this has been ;-(

27.07.2025 20:42 — 👍 0    🔁 0    💬 1    📌 0

New Mammography Tools — The Need for Clinically Meaningful Assessment Standards | NEJM AI mammography aids are being sold as additions to mammography screening, with direct-to-consumer marketing touting improved cancer-detection rates, despite a lack of evidence of clinical effective...

She is right - particularly when you take into account the overdiagnosis inherent in AI augmented breast cancer screening

www.nejm.org/doi/full/10....

23.07.2025 04:57 — 👍 1    🔁 0    💬 1    📌 0

good one

19.04.2025 14:33 — 👍 3    🔁 0    💬 0    📌 0

it's working for me on a Firefox browser from Berkeley, California

today's image is of "Lunar Dust and Duct Tape" - a rover on the moon

28.03.2025 15:32 — 👍 0    🔁 0    💬 1    📌 0

I see a picture for March 23

24.03.2025 01:56 — 👍 0    🔁 0    💬 1    📌 0

Applying cost minimization techniques is the simplest way to be cost effective in the clinic - so many times a day one strategy clearly dominates over the other

29.01.2025 17:07 — 👍 0    🔁 0    💬 0    📌 0

Only a subset of patients respond to immunotherapy

Why? Which ones?

We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.

www.nature.com/articles/s41...

27.11.2024 14:13 — 👍 132    🔁 47    💬 4    📌 5

Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer - Nature The phase 3 SONIA trial challenges the benefits of using cyclin-dependent kinase 4 and 6 inhibitors as a first-line compared with second-line treatment.

This is how we should be doing Oncology trials - the Dutch SONIA trial looking at treatment sequencing of CDK 4/6 inhibitors in advanced breast cancer. A self funding efficiency trial! #oncsky www.nature.com/articles/s41...

27.11.2024 19:24 — 👍 21    🔁 8    💬 1    📌 0

Mill Valley after the rain

28.11.2024 21:39 — 👍 3    🔁 0    💬 1    📌 0

Went to hear Van Morrison in a small venue. He was fantastic.

Funny how his “North American tour is one town in New Hampshire and the rest in California.

19.11.2024 20:20 — 👍 2    🔁 0    💬 0    📌 0

Yes - sad but true

28.04.2024 19:39 — 👍 1    🔁 0    💬 0    📌 0