Sean McKenzie

plsRT: Looking for a motivated postdoc!
Join us at @bcmhgsc.bsky.social to explore the mosaic & somatic landscape of the human genome: structural variants, methylation, and all things @smahtnetwrk.bsky.social
If you like long reads, complex variants & methylation come talk to me!

10.11.2025 14:12 — 👍 0    🔁 2    💬 0    📌 0

Trio-barcoded @nanoporetech.com Adaptive Sampling (TBAS) to improve #RareDisease diagnostic at less than 1/2 the $$ & high cov: 76% solve rate across 13 trios inc. two corrections from prev. diagnosis. www.medrxiv.org/content/10.1...
@gregor-research.bsky.social @bcmhgsc.bsky.social
#Research

27.10.2025 13:05 — 👍 5    🔁 3    💬 0    📌 0

Autocycler: long-read consensus assembly for bacterial genomes AbstractMotivation. Long-read sequencing enables complete bacterial genome assemblies, but individual assemblers are imperfect and often produce sequence-l

Happy to share that the paper describing Autocycler is now 100% up:
doi.org/10.1093/bioi...
(1/3)

29.09.2025 04:11 — 👍 65    🔁 36    💬 1    📌 0

Applications Bioinformatician (8 month temporary role) We are looking for an individual with expertise in bioinformatics and data analysis, specializing in microbial genomics and metagenomics, to join our Applications team as an Applications Bioinformatic...

ONT has a temporary bioinformatics position (8 months) open while I'm on maternity leave. Focus will be on microbial genomics but with opportunities to work on projects across the breadth of genomics!
ejnh.fa.em2.oraclecloud.com/hcmUI/Candid...

27.08.2025 19:04 — 👍 3    🔁 3    💬 0    📌 0

Usually avoid politics on bluesky, but PBS is a particularly special cause for me: The House will vote this week on a massive cut to public media funding. Your local stations are at risk. Call your Rep. now and urge them to vote NO before it’s too late. bit.ly/3T68Qgw #ProtectMyPublicMedia

10.06.2025 00:05 — 👍 2    🔁 0    💬 0    📌 0

It's been a good month for Nanopore assembly preprints! This time metagenomic assembly with nanoMDBG: hundreds of high-quality MAGs from high-complexity communities

25.04.2025 20:06 — 👍 6    🔁 3    💬 0    📌 0

Exciting preprint from Haoyu Cheng (not on bluesky?) and @lh3lh3.bsky.social: building amazing Nanopore assemblies just got faster and more accessible! Thrilled to have played a small part in this work!

18.04.2025 12:52 — 👍 7    🔁 3    💬 0    📌 0

Application note: Oxford Nanopore sequencing provides superior MAG recovery and strain-level resolution from a complex microbiome | Oxford Nanopore Technologies In this application note, we demonstrate the capabilities of Oxford Nanopore metagenomics by sequencing and analysing the well-characterised ZymoBIOMICS Fecal Reference.

Check out our new Apps Note on metagenomic assembly of the Zymo fecal reference with nanopore sequencing and metaMDBG. Almost 200 Gb of metagenomic sequence data from a single PromethION flowcell, yeilding hundreds of high-quality metagenome assembled genomes: nanoporetech.com/resource-cen...

19.12.2024 17:55 — 👍 8    🔁 4    💬 0    📌 1