Christian Wilms

Here's a recap of Standard Notes in 2025 and what’s coming in 2026 🗒️

This year, we delivered 30+ fixes and improvements, and with support from Proton, Standard Notes has been strengthened without changing what makes it special.

More in thread 👇

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Meme that shows a telescope in front of Christmas tree and presents, with several exclamations overlaid in Comic Sans: - I'm not a Christmas present! - I'm not a toy! - I'm not disposable once the holidays are over! - I'ma 15-20 year commitment! - I'm family!

#astrophotography

The experience of seeing Saturn’s rings for the first time with your own eyes is something, it really is. Or the Mars ice cap

I mean, who would have thought that web catalogs (i.e. hand curated lists of webpages on a topic) would make a return thirty years later?

The Psychological Impact of Digital Isolation: How AI-Driven Social Interactions Shape Human Behavior and Mental Well-Being Felix Eling 3697-3705 Apr 30, 2025 Education The Psychological Impact of Digital Isolation: How AI-Driven Social Interactions Shape Human Behavior and Mental Well-Being Felix Eling Faculty of Health Sciences, Department of Pharmacy, Gulu College of Health Sciences, Gulu City, Northern Uganda DOI: https://dx.doi.org/10.47772/IJRISS.2025.90400265 Received: 13 March 2025; Revised: 22 March 2025; Accepted: 25 March 2025; Published: 30 April 2025 ABSTRACT The increasing integration of artificial intelligence (AI) in social interactions has transformed how humans experience companionship, communication, and mental well-being. This review examines the psychological impact of AI-driven social interactions, focusing on virtual assistants, AI chatbots, and digital companions. It explores the benefits, risks, and ethical concerns associated with AI companionship. A systematic review methodology was employed, detailing inclusion criteria, databases searched, and analysis techniques. Findings suggest that while AI can offer emotional relief and support, over-reliance may disrupt real-world social bonding. Ethical concerns such as data privacy, emotional manipulation, and regulatory gaps are highlighted. The study underscores the need for balanced AI integration in human socialization. The study also addresses gaps in previous literature by examining AI’s influence on different demographic groups and cultural contexts.

Let me tell you a story. Perhaps you can guess where this is going... though it does have a bit of a twist.

I was poking around Google Scholar for publications about the relationship between chatbots and wellness. Oh how useful: a systematic literature review! Let's dig into the findings. 🧵

Read yet another review today that ascribes GECIs' larger SNR vs GEVIs to their being evolved earlier (suggesting the GECIs are better optimized). This assumption is understandable but incorrect. GEVIs' photonic response per molecule per AP have been as good as GECIs since ASAP3.

One note here: if SNR / photon flux is limiting (as in most in vivo situations), imaging fast is a problem — I’m expanding on “if you can image fast”.

Ich habe in so kurzer Zeit eine fast körperliche Abneigung gegen diese mit AI erzeugten Eventflyer entwickelt, kann ich bitte die schlimmen selbstgebastelten Flyer mit Comic Sans noch mal sehen?

Inaugural lecture to the faculty of Yasin Dagdas (@plantophagy.bsky.social) and Simon Wiegert (@simwieg.bsky.social) - bridging green and red biology.

Zeit die Kinder für die erste Fremdsprache Mandarin anzumelden.

I see this with the VPN at work as well: Cloudflare tends to throw captchas much more frequently. It is what it is.

yeah, that’s weird. But if something goes wrong, you can try the one I’m using.

Flyer for the BonnBrain conference: Keynote lectures: Cori Bargmann, Edvard Moser, Maude Baldwin, Rosa Paolicelli, Zachary Knight Invited speakers: Inna Slutsky, Abhilasha Joshih, Dmitriy Aronov, Ruben Portugues, Laura Busse, Kishore Kuchibhotla, Long-Jun Wu, Rune Enger, Ania Majewska, Sarah Melzer, Carolina Rezaval, Josh Dudman Specials: Selected talks, young investigator symposium, posters, career session with Leonie Welberg from Nature Neuroscience & more

Join us for BonnBrain 2026!

The official deadline for abstract submission is December 15th, but we only have a few slots left and might be sold out before the deadline.

Apply quickly 👉 bonnbrain.de to be considered by our Scientific Committee!

Speedwise, Proton VPN is fine for that. Just constant checks of my humanity.

I am slowly wondering if they might be on to something there 😉

This experience is way too close to home. It is worth keeping close tabs on blood pressure when pregnant and knowing that swelling of fingers and in the face should not be dismissed as "normal for a summer pregnancy" without checking. Partners should have this on their radar as well.

An update of one of our papers has been posted to biorxiv. Stas, Yang, Schultz and Go, "Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer's disease".
www.biorxiv.org/content/10.1...

A holiday demonstration of the different penetration depths of red and blue light into tissue.

#optics

Not reassuring this early separation already in 2 days

Fits perfectly with this not being a study on the effects of drinking coffee but of sudden withdrawal of coffee. The fact that this was published without the actual control group (people who don't drink coffee at all) is quite schocking. Doesn't speak for the journal.

Sorry @erictopol.bsky.social it doesn't. All participants were normal coffee drinkers. Therefore, the coffee-drinker arm is the Control arm. The intervention of going cold turkey increased the hazard of AF by 64% (100/0.61). The whole report is written from the wrong perspective.

Purified proteins? In cultured cells? In an intact organism?

On cells, I faintly recall the mitochondrial outer membrane assay for cultured cells. Just to add more options to this thread 😁

Isn't the biggest issue with BiFC that the probes themselves have a binding affinity that is non-zero?

I would lean towards some form of FRET assay. Ideally using fluorescence lifetime as readout. But I might be a bit biased 😉

You haven't by chance started using a VPN?

The case of the disappearing teaspoons: longitudinal cohort study of the displacement of teaspoons in an Australian research institute Objectives To determine the overall rate of loss of workplace teaspoons and whether attrition and displacement are correlated with the relative value of the teaspoons or type of tearoom. Design Longitudinal cohort study. Setting Research institute ...

70 teaspoons placed in tearooms around the institute & observed weekly over 5 months. 80% of spoons disappeared; spoon halflife~81 days. Communal room halflife lower than in specific labs. 250 spoons annually required to maintain 70 spoon population.

pmc.ncbi.nlm.nih.gov/articles/PMC...

The annual course “Basics in Fluorescence Microscopy”, will be organised by the van Leeuwenhoek Centre for Advanced Microscopy from January 27th - 30th, 2026.
Location: University of Amsterdam (NL)
For more info, preliminary program and the application form check www.microscopycourse.nl?page_id=78

DeepEn is at NEUROSCIENCE 2025 #SfN25 ! 🧠🔬🌴
Come to our BOOTH #3027, check our microendoscope for deep brain imaging with sub cellular resolution and minimal tissue damage.
And meet Hana, Tomas, Patrick and Jiri!

#neuroimaging

Reposting this from #SfN25 in San Diego, where this collaboration takes off in fashion! 📣 🥳

Day 1 #SfN2025 exhibition has opened its doors.

You can find @martinbrill.bsky.social and @swarnck.bsky.social with our friends from 89North and Chroma Technology Corp. at their both no. 2021.

Come by and let's talk about your experiments and #photomanipulation from @rappopto.bsky.social

this goes right along with my theory that the AI obsession in *users* is often bc…

1. they were never educated (esp "ipad generation") & don't know how computers work

2. our tools and services are all SO AWFUL NOW, degraded at best, actively user-hostile at worst

This is the price for the last DC SfN having sunshine and temps in the sixties 🫣