Christian Wilms

A @bob-goldstein-art.bsky.social original!

A screenshot of Typst.

I'm switching from Overleaf to Typst. So far so good.

If you like Overleaf but are occasionally annoyed by it, or are just interested in trying something new, Typst is worth a try. labrigger.com/blog/2025/08...

Put whatever objective you want on the Ventana Wide. It will give you the largest field of view with high speed scanning: eg, 3.2mm x 3.2mm with a 10x. Fast, flexible 2p imaging.

Che-Hang Yu is helping MBL courses with this Ventana Wide system pacificoptica.com/ventana/

Always a silver lining :)

I was surprised how therapeutic running can be.

This is harder for you than for us who preordered. I have learned patience, so my fingers are crossed and eyes are peeled! Good luck!

A sensitive orange fluorescent calcium ion indicator for imaging neural activity Genetically encoded calcium indicators (GECIs) are vital tools for fluorescence-based visualization of neuronal activity with high spatial and temporal resolution. However, current highest-performance...

#OCaMP is now on bioRxiv and reagents are available on #Addgene! 🧪

A sensitive orange fluorescent calcium ion indicator for imaging neural activity

www.biorxiv.org/content/10.1...

Two graphs and a microscopy image. The top graph shows a periodically spiking trace, with a scale bar indicating 1 second. The bottom-left graph shows a zoomed-in portion of that trace, with a scale bar indicating 100ms. The trace seems to periodically rise and fall, with spikes occurring at the peaks. The bottom-right image shows a bright spot in an otherwise blotchy image, with a faint trace indicating a recorded neuron.

You know that feeling when a tricky experiment actually works? I finally managed to record a Striatal Cholinergic Interneuron in vivo, with voltage imaging; how cool is that!

Guess it makes sense that they used to call these tonically active neurons!

🧠 #neuroskyence #neuroscience

Motherfucking wind farms…

New dopamine sensor powers three-color imaging in live animals The tool leverages a previously unused segment of the color spectrum to track the neurotransmitter and can be used with two additional sensors to monitor other neurochemicals at different wavelengths.

A new molecular sensor leverages a previously unused segment of the color spectrum to track dopamine and can be used together with two additional sensors that monitor other neurochemicals at different wavelengths.

By @dianakwon.bsky.social

#neuroskyence

www.thetransmitter.org/methods/new-...

The Strathclyde Optical Micoscopy Course #SOMC25 kicked off today - 10 days of practical light microscopy training with 24 students from around the world!

From fundamental & advanced lectures, to hands-on workshops with high end systems, & a field trip to the Isle of Cumbrae, it will be great! 🔬

Fantastic to see this collaborative work with Hopi Hoekstra out in Nature (tinyurl.com/3at3zvby). Lead by @felixbaier.bsky.social and @katjareinhard.bsky.social. Not possible without @bramnuttin.bsky.social , Chen Liu and @arnausd.bsky.social.

Excited to see where this work leads.

📌

And has been for a long time. I don't think I have been there this century 🫣

Very fond memories of Colossaal. Many a great evening and night spent there. ☺️

We’ve got a new cell biology #jobs board on FocalPlane to help with this!
focalplane.biologists.com/cell-biology...

Also Microscopy jobs, powered by MicroscopyDB: focalplane.biologists.com/jobs/

And the famous jobs board on @the-node.bsky.social: thenode.biologists.com/jobs/

🎉 Heron is finally out @elife.bsky.social! Led by George Dimitriadis, with Ella Svahn & @macaskillaf.bsky.social

🧪 🧠 🐭 🤖

If you wonder why yet another tool for experimental pipelines, read the 🧵 below:

#neuroscience #neuroskyence #OpenSource

1/
elifesciences.org/articles/91915

The overall message is that GFP-based ASAP voltage indicators provide high brightness, speed, and response amplitudes and genetic targetability, so that fast voltage events such as gamma oscillations can be studied without too much trouble.

Two voltage imaging studies in two days using ASAP fluorescent indicators.

First, visualizing electrical brain waves with ASAP3, in Cell. Free link below. Though recorded by EEG for 100 years, how brain waves arise from different neuron types has been unclear.

authors.elsevier.com/sd/article/S...

TetO‐jGCaMP8s is a drop in replacement for the @crisniell.bsky.social mice with all the nice properties of 8s. High, dense expression, and doesn't have the aberrant activity. Was used here: www.nature.com/articles/s41...

Has anyone got any experience with gcamp8 transgenic mice yet? Eg the Thy1-GCaMP8s line?

janelia.figshare.com/articles/dat...

Exploring the Brain - One Spine at a Time 🔬
Just chatted with @sainsburywellcome.bsky.social about our latest work, miniaturising two-photon microscopy for neuroscience at @kavlintnu.bsky.social
www.sainsburywellcome.org/web/qa/mini-...
A few highlights:

A summary figure for a NeurIPS competition where AI agents compete with mice in a visual foraging task.

Mice learn these tasks and are robust to perturbations like fog. Now, we invite you all to make AI agents to beat mice.

We present our #NeurIPS competition. You can learn about it here: robustforaging.github.io (7/n)

The Story of Samuel L Jackson In 2016 I was watching an episode of the Tonight Show with Jimmy Fallon. One of the guests on the show was Samuel L. Jackson, and as he made his entrance he struck a pose where he made a letter "L" with one of his hands before bringing it up to his chin. I thought "Well I guess his enantiomer would have to make a "D" with his hands.".

The story behind the most recognisable ChemScrapes meme. #chemsky

Seconding Affinity. The move from Illustrator to the affinity suite was easier than moving from Freehand to Illustrator for me.

Koprolalie wäre immerhin richtiger gewesen. Die große Mehrheit von uns Tourettis hat (im Gegensatz zum möchtegerne lustigen Klischee) keine Koprolalie. Wir zucken, blinzeln, verrenken uns, husten, pfeifen, grunzen, schnallen mit der Zunge, usw. Tics halt.

Und das metaphorische Verwenden eines falschen Klischees einer echten Erkrankung und das damit verbundene Fördern falscher Vorurteile ist in Ihren Augen OK?

Haben Sie mal Betroffene gefragt, wie sie das sehen? Ich denke meine Antwort ist klar.

Selbst wenn ein Kind schwimmen kann: auf Steg und Boot geht es (erstmal) nur mit Schwimmwesten. Reinfallen ist was anderes, als gezielt zum Schwimmen ins Wasser zu gehen.

Hat nichts mit Tourette zu tun oder auch nur im Ansatz gemein.

I admit that I am slightly envious 🙂