Irene Fernández Ugidos

Don't miss the deadline!

🚨Our preprint is online!🚨

www.biorxiv.org/content/10.1...

How do #dopamine neurons perform the key calculations in reinforcement #learning?

Read on to find out more! 🧵

Latest from the lab. Fantastic work by talented Irene Fernández @irenefu.bsky.social Send us your feedback!

Interesting! Nice work

New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬

We found that psilocybin prolongs the neurovascular response, independent of neural activity.

This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution - Communications Biology Three-photon in vivo imaging provides access to medial prefrontal cortex, hippocampus and spinal cord in mice at up to 1.7 mm depth of neurons, dendrites, spines, astrocytes and microglia.

It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week.
www.nature.com/articles/s42...

Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits | PNAS Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to stabilize key features of network activity, but whether these di...

Very happy that this work is finally out in ‪@pnas.org‬! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...

Check out the latest updates on Zach Plumley's @plumley.bsky.social project and give us feedback before we submit! Kudos to him and the rest of the team, including Irene Fernandez Ugidos @irenefu.bsky.social and Jennifer Calvo-Iglesias.

Exclusive: NSF stops awarding new grants and funding existing ones US science funder also plans to screen grant applications for compliance with ‘agency priorities’.

BREAKING: NSF has frozen all grant funding, as of yesterday. It's unclear when they will resume funding awards, or why the pause has been put in place. www.nature.com/articles/d41...

Info session: ERC grants for excellent frontier research Join EURAXESS North America and MSKCC us for a webinar on the bottom-up grants available from the European Research Council, the premier European funding organization for excellent frontier research.

📣 🇺🇸 and 🇨🇦 researchers! How about bringing your excellent research ideas to Europe? Learn more about the prestigious @erc.europa.eu grants in a webinar on May 6.

euraxess.ec.europa.eu/worldwide/no...

Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors Stress-induced depression-like behaviors are driven by a dynamic recurrent network involving neurons and astrocytes in the lateral habenula and norepinephrine release from neurons in the locus coeruleus in freely moving mice.

Now online! Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors

Really nice paper demonstrating astrocytic control of amygdala-dependent fear memory!

Registration is open for a few more weeks but if you’re a trainee and want to be considered for one of the four talking slots please register before this weekend. We are selecting speakers on Monday.

www.eventbrite.ca/e/neural-cir...

Functionally distinct GABAergic amacrine cell types regulate spatiotemporal encoding in the mouse retina - Nature Neuroscience GABA is the primary inhibitory neurotransmitter in the central nervous system. Using two-photon GABA imaging, Matsumoto et al. reveal over 40 GABA neuron types in the mouse retina, each uniquely filte...

Two-photon imaging of #GABA release in the inner plexiform layer of male and female mice retinae (8–16 weeks old) reveals over 40 different GABA-releasing neuron types 🧪🧠

www.nature.com/articles/s41...

Organizing a #SfN25 nano is a great opportunity to network and connect with others in your field.

Register today! bit.ly/4jA3aXr

Bright and photostable yellow fluorescent proteins for extended imaging - Nature Communications Yellow fluorescent proteins (YFPs) photobleach rapidly, restricting microscopy experiments. Here, the authors report mGold2s and mGold2t, YFPs that extend imaging durations up to 25 times longer than ...

Bright and photostable yellow fluorescent proteins for extended imaging by François St-Pierre and team:
www.nature.com/articles/s41...

Very nice work!

Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

Nature research paper: Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors

https://go.nature.com/4lev255

75% of US scientists who answered Nature poll consider leaving More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪

www.nature.com/articles/d41...

Recognizing excellence in neuroscience strengthens the entire field.

The 2025 SfN Awards and Prizes celebrate the researchers, educators, and mentors who drive neuroscience forward.

Nominate a colleague, friend, or peer by Thursday, May 8.

🔗 bit.ly/4iXFGLz

#Neurosky

Single-cell spatial transcriptomic atlas of the whole mouse brain Han et al. used snRNA-seq and Stereo-seq to generate a detailed mouse brain atlas with over 4 million spatially resolved cells and 29,655 genes. Their findings include region- enriched cell clusters and genes, spatiotemporal dynamics of transcription factor regulons, and a gene-based parcellation framework, providing a comprehensive resource for brain architecture.

Online now:

Today: pottery

eNeuro logo. JNeurosci logo. SfN Journals: In Conversation. An Open-Source 3D-Printable Platform for Testing Head-Fixed Cognitive Flexibility in Rodents. Tuesday, March 25, noon– 1 p.m. EDT. Speaker: Tim Spellman (University of Connecticut School of Medicine)

Join Tim Spellman and #eNeuro Reviewing Editor Mark Laubach in the upcoming #ResearchInConversation webinar to discuss an innovative platform offering a new tool for neuroscience research w/ broad applications in translational neuroscience.

#NeuroSky

New in Bluesky! Interested in neuroscience, synaptic plasticity and dendritic spines 🔬Currently in Mostany Lab at Tulane working with two-photon and exciting plasticity projects. Ah, I also do ceramics 🏺

Targeting NMDA receptor subunit reverses fragile X traits in mice The subunit acts as a “volume control” on signaling that shapes the density of dendritic spines, the new work suggests.

A new target for promoting plasticity of dendritic spines can also ease fragile X traits in mice, a new study shows.

By @avaskham.bsky.social

#neuroskyence

www.thetransmitter.org/spectrum/tar...