We show no improvement in pathogen detection or genome recovery X10 with longer turnaround time and higher failure rates for the dual-arm approach.

04.02.2026 18:39 — 👍 1    🔁 1    💬 0    📌 0

Comparison of nanopore methods for respiratory clinical metagenomics Respiratory metagenomic sequencing is increasingly used for rapid, pan-microbial diagnosis in clinical practice, but there is a need to evaluate different wet lab protocols for performance and feasibi...

Our latest preprint compares the dual-arm nanopore workflow with the respiratory metagenomics protocol currently implemented across the NHS, using clinical samples.

👉 www.researchsquare.com/article/rs-8...

@nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social

04.02.2026 18:36 — 👍 3    🔁 4    💬 1    📌 0

Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections Snell et al. develop sequencing methodology to identify full-length spike haplotypes and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence, accelerating viral evolution an...

This is finally out.

Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.

This is why persistent infections matter

www.cell.com/cell-reports...

02.02.2026 16:09 — 👍 81    🔁 43    💬 3    📌 3

Two men having a conversation

A panel of speakers answering a question

A woman wearing a grey blazer and blue lanyard answering a question

A grand hall with large windows and chandeliers. All audiences members facing a screen that displays 'Welcome to the NHS Respiratory Metagenomics Network Day'.

What an inspiring day! Last week we hosted our second Network Day, bringing together over 120 people. We explored the development of the national pilot metagenomic service, which is improving detection & treatment of respiratory infections. Thank you to all who joined and to our fantastic speakers!

13.11.2025 16:52 — 👍 3    🔁 2    💬 2    📌 0

Implementing rapid pan-microbial metagenomics in paediatric intensive care https://www.medrxiv.org/content/10.1101/2025.10.07.25337257v1

10.10.2025 21:43 — 👍 2    🔁 2    💬 0    📌 0

All additional positives, not detected by culture standard of care, were confirmed by PCR or 16S - so metagenomics more accurately reflects what is in the sample 👍

02.10.2025 18:20 — 👍 2    🔁 0    💬 0    📌 0

New research article

Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #OpenAccess #OA

02.10.2025 08:47 — 👍 21    🔁 6    💬 2    📌 3