Anderson Silva

a cartoon character stands in front of a map of the world . Alt: Yakko Warner stands in front of a map of the world .

Bad Bunny, 2026

Elmo @elmo · 1h That Bunny was AMAZING. Elmo thinks he should be called Good Bunny! Elmo loves you, Mr. Good Bunny! ❤️🎶🐰 Based Yankee @thebasedyankee You and Bad Bunny should be deported

It's not even midnight and we're already at "Deport Elmo."

Pop star Bad Bunny needed a Puerto Rican history scholar. UW–Madison had just the one. Bad Bunny collaborated with UW–Madison history professor Jorell Meléndez-Badillo on Puerto Rican narratives that accompany the new album “DeBÍ TiRAR MáS FOToS.”

Bad Bunny has a consulting historian. news.wisc.edu/pop-star-bad...

acho que o argumento não tinha nem que ser esse, mas sim que músculos te protegem de quedas na velhice

tem gente na minha família que literalmente morreu disso

Kim Meylemans and Nicole Silveira kissing at their wedding. They are both in white vests and their arms look incredible.

Kim Meylemans and Nicole Silveira

Kim Meylemans and Nicole Silveira kissing with Santa hats on.

I just found out about Nicole Silveira and Kim Meylemans who are skeleton racers in this years Olympics (for Brazil and Belgium, respectfully) who are also wives and also adorable.

LIU KANG WINS
FINISH HIM

O recado tá dado! 🌍

Falar de identidade, respeito e humanidade é lembrar que migrar não é crime, é um direito humano, fruto de contextos de vulnerabilidade, busca por proteção e dignidade.

natalia beauty
writes with AI in a paper that nobody reads

a JK assinava os e-mails pro Epstein do mesmo jeito que assina os tweets, e depois que as coisas vieram à tona, apagou todo o registro de atividade do iate dela

transfóbica e acobertadora de pedófilo, será que já é suficiente pra desapegar de um livro que você gostava quando tinha 12 anos?

uma batata após a outra

Rolê errado detected

😭

YouTube video by Kat Waiting for Guffman- Chinese Restaurant Scene

Catherine O’Hara was so good in Waiting For Guffman.
The way she drinks that wine at 0.30 & then we’re off…
youtu.be/MsqHBexWD1w?...

Absolutely devastating. I know she was well beloved, but even with that being considered, I find her to be incredibly underrated.

She’s on the level of Robin Williams, etc.

Os gays já se divertiram, agora é a vez dos casais heteros abusivos codependentes que discutem em voz alta no McDonald's as duas da manhã

a única explicação plausível pra esse post é se a pessoa acordou de um coma depois de ter passado a infância dentro de um iglu e já foi direto pra internet postar no bluesky

what a beautiful wedding

what a beautiful wedding says a bridesmaid to a waiter

and, yes, but what a shame what a shame the poor groom's bride is a whore!!!!!

Heated Rivalry and the Art of Anti-Dystopia Joy in the present makes joy in the future seem plausible.

Dystopia limits our imaginations, and also those of film and TV creators. It presents a world beyond repair, and consequently, futile to be engaged with or salvaged. A world where creativity is pointless, pleasure is dissociation, and sincerity and tenderness an invitation for humiliation and pain.

Heated Rivalry and the Art of Anti-Dystopia Joy in the present makes joy in the future seem plausible.

Dystopia at its core is about cynicism. It doesn’t have to be science fiction to be a dystopia. So often, shows set in a world indistinguishable from our own are peopled with characters who are almost anaphylactically averse to experiencing or communicating genuine emotion.

Heated Rivalry and the Art of Anti-Dystopia Joy in the present makes joy in the future seem plausible.

Dystopia is an intensely conservative, hypnotic tool. Every vision that has, for decades, depicted the future as a dissolute, perverted, joyless world fallen from grace has conditioned us to expect this inevitable, hopeless fate: more of the same, but worse. jenka.substack.com/p/heated-riv...

Heated Rivalry and the Art of Anti-Dystopia Joy in the present makes joy in the future seem plausible.

Heated Rivalry shows us that the most transportive, visionary, speculative future isn’t one that looks different from our reality. It’s one that feels different. It’s a difference that we as the audience can feel as if we’ve already lived in that world too.

anúncio do Instagram, bem colorido e misturando formas ilustradas e fotografia. ao centro está uma bolsa rosa de tamanho grande, com a legenda: Bolsa analógica: Uma tendência que saiu do TikTok e pode transformar seus momentos offline. Sua nova companheira de aventuras.

ah caras...... plmdds só saiam de casa igual gente normal

finalmente entendi o que o povo tanto dizia que eu cantava errado a musica!!!!!

"Na madrugada vitrola rolando um blues, tocando de biquini facial" 🎶🎶

yea she’s the goat

YouTube video by THE FIRST TAKE Silica Gel - BIG VOID / THE FIRST TAKE

Silica Gel - BIG VOID / THE FIRST TAKE youtu.be/-WaqfssyQ0E

For more than a century, Alzheimer’s disease has been framed as irreversible. Once memory and thinking decline, recovery has not been considered possible. That belief shaped nearly all research, which focused on prevention or slowing damage, not repairing it. Now, researchers from University

Highlights •Severity of Alzheimer's disease (AD) correlates with NAD+ homeostasis dysregulation •Preserving brain NAD+ homeostasis prevents AD in mice • Restoring brain NAD+ homeostasis reverses advanced AD in mice • Multiomics across human and mouse AD brain identifies nodes for human AD reversal Summary Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible.

Abstract Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.

Graphical Abstract (CREDIT: Cell Reports Medicine)

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️