POP-GEM Lab

Neuropsychiatric Outcome Inequities After Brain Trauma in the All of Us Database This cohort study examines the incidence of neuropsychiatric diagnoses following traumatic brain injury among All of Us Research Program participants and the factors associated with racial and social ...

(2/2) Link here 🔗: jamanetwork.com/journals/jam...

(1/2) Congrats to Tadeusz Wroblewski and co-authors on their new JAMA Network Open paper using NIH All of Us data! The study reveals racial disparities in post-TBI neuropsychiatric outcomes and highlights the impact of structural and social factors on recovery.
@timbigdeli.bsky.social

Good morning #WCPG2025 @ispg.bsky.social! I'm so excited to talk about my latest work performing inclusive QC in Lifelines! Come find me at M89 later today! This is the first fruit of my work with Dr. @roseannpeterson.bsky.social, the @popgemlab.bsky.social and Prof. Dr. Hanna van Loo.

(6/6) Dr. @nscorralfrias.bsky.social will discuss the LAGC-MDD’s meta-analytic GWAS efforts, followed by Dr. @roseannpeterson.bsky.social remarks on the importance of including ancestrally diverse populations in psychiatric genomics. #WCPG2025 #LAGC #PsychiatricGenomics

(5/6) Dr. Diana Núñez-Ríos will present analyses of CNVs in Colombian, Mexican, and Puerto Rican cohorts (947 cases, 310 controls), revealing complex admixture patterns and genetic variants linked to MDD. #WCPG2025 #MDD

(4/6) Dr. Amanda Rodríguez-León will share findings from a Puerto Rican cohort (n = 237), showing that COVID-19 stressors were linked to increased MDD/PTSD symptoms and accelerated epigenetic aging, especially among women. #WCPG2025 #LAGC #MDD #PTSD

(3/6) Dr. Gabriela Martínez-Levy will discuss research in a Mexican adolescent cohort (n = 1,134), examining how polygenic scores predict MDD and related traits, and how adversity shapes these genetic effects. #LAGC #WCPG2025

(2/6) Latin America has one of the highest global rates of MDD (~12%) yet remains underrepresented in psychiatric genetics. This session explores new findings addressing that gap through cross-ancestry research. #WCPG2025 #LAGC

(1/6) We’re excited to present “Advancing the Understanding of Depression Genetics Through Research on Latin American Genomes” at #WCPG2025! 🌎✨
Mon Oct 20 | 9:45–11:15 AM
Blue River 3 – Convention Center, Cancún
Led by Drs. @roseannpeterson.bsky.social @nscorralfrias.bsky.social 🧵...

Congratulations to #LanieMullins, PhD student #VCU_VIPBG, on receiving the Rising Star Award at #BGA2025 🎉 Her poster using #UKBiobank data linked immune system markers (MLR/NLR) to depression, with NLR emerging as a stronger predictor in older adults.

🚨 New paper out! In a collaboration across MVP, FinnGen & UK Biobank, we conducted a phenome-wide study of sex chromosome trisomies (SCT) in 1.5M participants. Findings reveal shared disease risks across SCT. 🔗 www.sciencedirect.com/science/arti...

🧠 Also in the invited symposium:"Electronic health records, genetics, and the promise of precision psychiatry"
Tues, May 20th | 3:45–5:15 PM PDT
Dr. Tim Bigdeli shares Million Veteran Program insights on EHRs, polygenic scores & dementia.
#EHR #Genomics
@timbigdeli.bsky.social

🧬 Join us at #APA2025 in LA for the invited symposium:
"Electronic health records, genetics, and the promise of precision psychiatry"
Tues, May 20th | 3:45–5:15 PM PDT
@roseannpeterson.bsky.social opens with PsycheMERGE: using EHR-linked biobanks to promote equity in psychiatric genomics.

(3/3) To advance psychiatric genetics in Latin America & the Caribbean:
🧬 Inclusive GWAS
📊 Regional data & infrastructure
👏 Big thanks to the authors & LAGC!
@egatkinson.bsky.social @giustilab.bsky.social @janitzamontalvo.bsky.social @roseannpeterson.bsky.social

(2/2) Despite the high burden of mental health conditions, Latin American and Caribbean populations remain underrepresented in psychiatric GWAS.
This review highlights:
🧬 Genetic diversity
📉 Gaps in data and representation
🤝 Opportunities for collaboration

(1/1) 🧠🌎 Just published in Nature Genetics:
“Psychiatric genetics in the diverse landscape of Latin American populations”
A comprehensive review of progress, challenges, and future directions.
🔗 www.nature.com/articles/s41...
#PsychiatricGenetics #GlobalGenomics

Psychiatric genetics in the diverse landscape of Latin American populations - Nature Genetics Latin America and the Caribbean remain largely underrepresented in psychiatric genetics research. This Review highlights the need for more research in these populations to advance genetic insights and...

📃 I am excited to share our @naturegenet.bsky.social review paper on the state of psychiatric genetics in Latin America, put forth by the Latin American Genomics Consortium (LAGC)! 🎉

www.nature.com/articles/s41...

🌟New review in Psychiatric Clinics: Closing diversity gaps in psychiatric genomics is vital for health equity. 📖Read: doi.org/10.1016/j.ps...
@roseannpeterson.bsky.social @giustilab.bsky.social @janitzamontalvo.bsky.social @nokewole.bsky.social

New preprint🌍 Our trans-ancestry GWAS in UK Biobank uncovers novel risk loci for major depression, improving genetic insights across populations. 🔗: www.medrxiv.org/content/10.1... @madhurbsingh.bsky.social @gentyae.bsky.social @pbb319.bsky.social timbigdeli.bsky.social @roseannpeterson.bsky.social

New paper! Led by Kirsten J. M. van Hooijdonk & Jacqueline Vink, this study finds no bidirectional causal link between diet/physical activity & depression/anxiety using triangulation. No strong causal evidence! @zoereed.bsky.social @madhurbsingh.bsky.social
📖 doi.org/10.1017/S003...

🚀 New paper by @madhurbsingh.bsky.social on smoking & DNA methylation via twin-based MR using @ntrbiopsy.bsky.social data! Supervised by Mike Neale, @jennyvandongen.bsky.social, & Conor Dolan. Co-authors: @dlapato.bsky.social, @charlesbreeze.bsky.social. 🔗 doi.org/10.1007/s106...

Thrilled to share some amazing news— @madhurbsingh.bsky.social, supervised by Roseann Peterson, PhD, and Michael C. Neale, PhD, has been awarded VCU VIPBG's Kenneth S. Kendler Award for Excellence in Predoctoral Research!