Johansen B Amin MD PhD

Trump’s administration fired 1500 NIH employees along with thousands from related agencies. The loss of experience and knowledge is incalculable.

Many scientists in my lab came to the US to avoid authoritarianism.

They all say the same thing:

“I can’t believe this is happening here”

Epilepsy Patient Samples Offer Unprecedented Insights on Brain ‘Brakes’ Linked to Disorders Specific protein receptors in the brain play a vital role in how neurons slow down or stop firing, making them targets for many disorders. Researchers have now constructed a detailed structural map of...

Today in @natureportfolio.bsky.social: Research led by Jia Zhou in the Hibbs Lab @ucsandiego.bsky.social resulted in a map of the structures of human brain receptors. The study has implications for understanding signaling in the brain and for treating diseases like epilepsy.

📰 go.ucsd.edu/40lXlF4

urldefense.com/v3/__https:/...

Synaptic protein expression in bipolar disorder patient-derived neurons implicates PSD-95 as a marker of lithium response Bipolar disorder (BD) is a severe mental illness characterized by recurrent episodes of depression and mania. Lithium is the gold standard pharmacothe…

We made neurons from patients with bipolar disorder who either responded to lithium, or didn’t. Synapses
from patients that did respond to lithium had more of a key protein that tells us a lot about why lithium stabilizes mood.

Free access link in comments!

www.sciencedirect.com/science/arti...

Reposting for the Science feed: 🧪

Our January issue is here ✨ https://buff.ly/3DFIr4N The cover shows agonist-induced #ionchannel opening of human NMDA receptors assayed using single channel outside-out patches to detect varied activation delays and failures. From Miaomiao He & @lwollmuth.bsky.social (https://buff.ly/3W6IQ6J).

Recovery-Oriented Principles Provide a Dynamic Reframing of Patient Care in Schizophrenia Since the mid-20th century, the treatment of schizophrenia has shifted from the institutional setting to the community care setting.1 Older treatment model

When your doctor asks you what your symptoms are, they treat your symptoms.

However, when your doctor asks you what your life goals are, they treat you in a way that optimizes your attainment of said goals, symptoms be damned.

That is what Recovery means.

academic.oup.com/schizophreni...

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission - Molecular Psychiatry Molecular Psychiatry - Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

Did you know there are identical twins where one has schizophrenia and the other doesn’t? Why?

This paper suggests their neurons have the same genes, but’s express them differently, and compensate at a network level, take a look:

www.nature.com/articles/s41...

Recovery-Oriented Principles Provide a Dynamic Reframing of Patient Care in Schizophrenia - PubMed Recovery-Oriented Principles Provide a Dynamic Reframing of Patient Care in Schizophrenia

Consider what happens when your doctor treats you based on what your goals are and not what your symptoms are.

Especially in severe mental illness, this is the difference between helplessness and empowerment.

pubmed.ncbi.nlm.nih.gov/39016199/

This is north of mission beach in San Diego. Really lovely this time of year.

Some posts a about molecular psychiatry… coming soon :)