Sarah Lambert's Lab

Condensin and topoisomerases cooperate to relieve topological stress at stalled replication forks Resolving complex topological structures at replication forks is vital for successful DNA replication, but the mechanisms are little understood. Evidence from diverse eukaryotes suggests that condensi...

New topology Pre-print from: @alengronne.bsky.social
Condensin and topoisomerases cooperate to relieve topological stress at stalled replication forks:
biorxiv.org/content/earl...

👏 Congratulations to Dr. Leïla Perié, team leader at @institutcurie.bsky.social who's been awarded an #ERC #ProofofConcept Grant for her project "VisioWell", the 1st accessible ex-vivo single-cell live-cell imaging device designed to analyse the dynamics of non-adherent cells.
#CellBio @cnrs.fr

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Two major events today on our campus!
🚴‍♀️First, the Tour de France is passing right next to us — @cnrsoccitanieest.bsky.social!
🧬Second, our latest paper on the role of G-quadruplexes (G4s) at promoters is now online at @natgenet.nature.com!

Postdoctoral Fellow - Costa Lab Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

🚀 Une année riche de nouveaux espoirs contre le #cancer !

📽️ Retrouvez en vidéo les temps forts qui ont marqué l’année 2024 à l’Institut Curie, à l’occasion de la sortie de son rapport annuel.

Sussex is the host for this year's South West Structural Biology Consortium meeting [we snuck in... !]. Looking forward to hearing talks from Universities of Bath, Bristol, Cardiff, Exeter, Portsmouth, Southampton and of course, Sussex!

Ready for #Yeast2025 in Paris tomorrow. Looking forward to the science and to seeing colleagues and friends.

This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...

Our paper is now out in Molecular Cell!

Check the thread in this former post:

www.cell.com/molecular-ce...

🔥🔥🔥 Read now our latest article: The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews - www.annualreviews.org/content/jour...

Are you a #PhD student in #Chile and want to develop your #SoftSkills?

Learn about #ScienceCommunication, #ethics, #creativity, #career #opportunities and more at the EMBO PhD Course in Chile! 🧪

Deadline extended to 27 July!

Apply now:
meetings.embo.org/event/embo-p...

Participez au #MarathondeParis 2026 tout en accélérant la recherche contre le cancer !
L’Institut Curie propose 100 dossards solidaires: 95€ d’inscription + une collecte de 420€ = un engagement sportif et solidaire au bénéfice des patients.
👉 marathon-paris.dossards-solidaires.org/project/cour...

🔬 The Multiscale Integration in Biological Systems course with @normalesup.bsky.social will explore how physical tools address biological complexity across scales.
Open to MSc/PhD students, postdocs & researchers in biology, physics & related fields.
👉 training.institut-curie.org/courses/mult...

we're hiring!

The surprise came from trans-sister maps: contacts above the diagonal - lower-coordinate loci on Sister 1 vs higher-coordinate loci on Sister 2 - outnumber the reverse. An asymmetric/biased matrix implies a genome-wide register shift between sisters in the 5->3 direction of inherited strands!! 5/

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/

Structure, function, and quality control of proteins in cell organelles Approximately 7000 human proteins are compartmentalized within a subcellular organelle at one point of their cellular life. A majority of these proteins are obligate organelle residents. With the exc…

Don't miss out – Deadline today for India | EMBO Lecture Course "Structure, function, and quality control of proteins in cell #organelles" in Hyderabad, India, 10–14 November 2025.

meetings.embo.org/event/25-org...
#EMBOorganelles #EMBOevents 🧪

I may be biased by my career stage, but I don't understand how anyone can look at the European academia (DACH, particularly) and conclude that we need even more centralization of research.

Apply to our PhD program!!

£2.3m awarded to study DNA replication stress Hasan Yardimci, Senior Group Leader at the Francis Crick Institute, has received a Wellcome Discovery Award for £2.3m to study how cells faithfully duplicate their genetic material when under stress.

Congratulations to @hyardimci.bsky.social on receiving a £2.3m @wellcometrust.bsky.social Discovery Award to study how cells faithfully duplicate their genetic material when under stress. 🥳

www.crick.ac.uk/news-and-fea...

Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO Sixty-nine new members join the community of leading life scientists in Europe and beyond

Congratulations to all newly minted @embo.org members. As these things go, especially to my #Czech colleagues @plevkalab.bsky.social of @ceitec.eu & Jan Konvalinka of @iocbprague.bsky.social & @mpi-cbg.de alumni Andy Oates & @nvastenhouw.bsky.social See ya in #Heidelberg
www.embo.org/press-releas...

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...

This is crazy !

Excellent read.

If you don’t have time to take a walk, then you don’t have time to do science. Charles Darwin would take two walks every day on his "thinking path", not as a break from science, but as a crucial part of it.

New Paper!
How do human B cells use dynamic DNA topology during antibody maturation? Our research published in Molecular Cell reveals how somatic hypermutation (SHM) and class switch recombination (CSR) work in the context of a regulated multiway 3D chromatin hub. (1/10) 🧵

Photos du procédé de fabrication de la pirogue. (A) Cèdre avant abattage. (B et C) Hache en pierre taillée avec manche en bois utilisée pour la coupe. (D et E) Découpe et façonnage de la pirogue. (F et G) Pirogue avant et pendant l'incinération. (H) Sièges en bois à l'intérieur et un fin bambou fixé sur le côté comme protection contre les vagues. (I) Pirogue terminée avant le départ, avec des protections contre les vagues en feuilles à l'avant (à droite) et à l'arrière (à gauche). Des perches verticales à l'avant et à l'arrière servent respectivement à une caméra et à un feu de poupe. Le câble à l'avant sert au remorquage. (J) Façonnage d'une pagaie monopale à l'aide d'une herminette en pierre taillée

Trace GPS du voyage expérimental de 2019. Les points rouges et bleu clair indiquent respectivement le jour et la nuit. Le cercle blanc représente la limite de visibilité (r = 50 km) de l'île de Yonaguni.

Comment les humains de l'âge de pierre ont-ils pu naviguer depuis Taïwan jusqu'au Japon?

Une équipe de scientifiques a construit un canoë en creusant le tronc d'un cèdre japonais avec des outils paléolithiques et a relié la côte est de Taïwan à l'île de Yonaguni en utilisant le soleil & les étoiles