Sarah Lambert's Lab

9 days to go:
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...

10-year celebration of the Fachinetti team!
Thank you to all my amazing current and former members for making these two days so special for me! I feel so lucky to have met you all!

Loop extrusion provides mechanical robustness to chromatin Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop e...

New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social
www.biorxiv.org/content/10.1...

Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.

Supporting scientists’ international mobility for more than five decades   – Features – EMBO A conversation with the Head of the Fellowship Programme, Karin Dumstrei

One of the core missions of EMBO is to grow and connect talents. Karin Dumstrei, head of the EMBO Fellowship Programme, tells us about how EMBO has been supporting scientists’ international mobility for more than five decades: www.embo.org/features/sup... 🧪 #research #funding #LifeSciences

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social
and Michelle Wang

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

Our chromatin scaling paper is now out in its peer-reviewed form! 🎉
We added some controls, statistics, and a new introduction to better contextualise our findings. Overall a much-improved version we hope! (see my earlier thread for the preprint background)
www.sciencedirect.com/science/arti...

📢 Lancement de la campagne ATIP-Avenir 2026

@cnrsbiologie.bsky.social et @inserm.fr ouvre la campagne ATIP-Avenir 2026, destinée à soutenir des projets de recherche innovants portés par de jeunes chercheuses et chercheurs.

📅 Toutes les informations : buff.ly/5DH6mpd

Creating connections in Crete – People – EMBO Meet George Garinis, professor at the University of Crete, affiliated group leader at the Foundation for Research and Technology – Hellas and EMBO Member

Meet George Garinis, professor at the University of Crete #Greece, affiliated group leader at imbb-forth.bsky.social and EMBO Member. “For me EMBO is all about connection,” he says, grateful for the role EMBO plays in facilitating #networking to other parts of #Europe: www.embo.org/people/creat... 🧪

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

Focus on Greece - EMBO communities in EMBC Member States Facts and figures, life scientists in Greece, EMBO opportunities

Supporting the #LifeSciences community through different programmes and schemes, scientific #publishing, #policy as well as #innovation, EMBO champions scientific excellence throughout #Europe and worldwide.

This week’s feature: #Greece

www.embo.org/the-embo-com...
🧪 #research #opportunities

Gerstner Sloan Kettering Graduate School of Biomedical Sciences The Gerstner Sloan Kettering Graduate School of Biomedical Sciences offers the next generation of basic scientists a program to study the biological sciences through the lens of cancer

Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer.
bit.ly/3WUiuo1

Learning about break-induced replication from bacteriophages Nature Reviews Molecular Cell Biology, Published online: 09 September 2025; doi:10.1038/s41580-025-00898-1Break-induced replication (BIR), a DNA double-strand break repair mechanism, was first studied in the 1960s in bacteriophages, showing that DNA could recombine by a 'break–copy' mechanism.

New Online! Learning about break-induced replication from bacteriophages

New important opportunity for young PI recruitment at our Institute! Please spread the news. Interested candidates should carefully check their eligibility for the indicated SNSF funding schemes, before submitting their application 👍 👇

www.imcr.uzh.ch/dam/jcr:3d1f...

www.imcr.uzh.ch/en.html

Tomorrow (Tue 9th) at 5 PM CET. Don't miss it!

🔬 Division cellulaire : comment une modification épigénétique protège nos chromosomes. L’équipe du Dr Daniele Fachinetti ( @institutcurie.bsky.social / @cnrs.fr), en collaboration avec l'université Stanford, révèle le rôle clé de la méthylation de l’ADN dans l’organisation des centromères.

Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...

📢Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4

DNA methylation influences human centromere positioning and function - Nature Genetics Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...

We’re back! Registration is NOW OPEN for the 6th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer. Don’t miss insights from leading experts in the field. Join us online on Nov 25, 2025—register for free: bit.ly/chromatin-2025 #chromatin2025

Pharmacologic interrogation of USP28 cellular function in p53 signaling Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28 probe, alongside a control compound and an inhibitor-resistant mutant. They show that USP28 inhibition mimics p53 path...

Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...

DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.

doi.org/10.1038/s415...

Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress - Nature Communications Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...

Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...

Fellowships, grants and career support – Maria Leptin | EMBO Science Journalism Fellowships – EMBO Supporting life scientists pursuing a career in science journalism and science journalists who wish to further their scientific education

The Maria Leptin | EMBO Science Journalism Fellowships support life scientists pursuing a career in #ScienceJournalism and science journalists who wish to further their scientific education.

Apply now:
www.embo.org/funding/fell...
#LifeSciences #ScienceCommunication #SciComm #Funding 🧪

🍂The 2025 Fall Session of GIIN webinars is here!
Join us on the 1st Tuesday of each month at 5 PM CET (Rome) / 11 AM DET (NYC). No pre-registration needed, just click to join via Zoom: uniroma1.zoom.us/j/95149984403
Subscribe here for webinar reminders: docs.google.com/forms/d/e/1F...