Oksana Iamshanova

📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...

👥 Speed Mentoring with cardiology icons at RISE @ ESC Congress 2025!

🌍 Small-group chats with world-class mentors
💬 Ask questions, gain insight, grow your network
🚀 Learn how to lead in cardiology

Register now: rise.womenasone.org

#LetsRISE2025 #ESCCongress #WCCardio #CardioSky

We are hiring! We have open PhD and postdoc positions in Bern. Join us to study sleep/wake circuits, and/or auditory functions with iEEG/EEG #iEEG #Neurojobs

Postdoc: neuro.inf.unibe.ch/menu/announc...
PhD: neuro.inf.unibe.ch/menu/announc...

We should have the equivalent for PIs looking for students and/or postdocs

🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky

Featured on #ESCTVToday - In 2000, Raymond Kim and his team showed that late gadolinium enhancement on cardiac MRI could predict myocardial recovery after revascularisation — a discovery that transformed cardiac imaging. ow.ly/bV2950WqnF8

This is figure 2 showing how SNAP-tag engineering is aiming for faster and brighter fluorescence labeling

SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/46fMIZd 🧪

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.

One last reminder, into the last couple of days!

Not so many applications from ion channel people- what are you waiting for patch clampers?

😀

🧑‍🔬🎙️ Did you know that JGP supports video summaries of your research? When you publish with JGP, you can reach more of your community by submitting a short video!
🎦 See our guidelines: rupress.org/jgp/pages/vi...
▶️ Watch video summaries from our authors: www.youtube.com/@JGenPhysiol

The role of connexin-43 in modeling arrhythmogenic diseases with induced pluripotent stem cell-derived cardiomyocytes - PubMed A common pathophysiological characteristic of arrhythmic diseases is the disruption of electrical signal transmission across the heart causing life-threatening rhythm disorders. These conditions are a...

New publication: The role of connexin-43 in modeling arrhythmogenic diseases with induced pluripotent stem cell-derived cardiomyocytes. Congratulations to the authors! pubmed.ncbi.nlm.nih.gov/40436246/
#CVRCBern

YouTube video by Swiss National Science Foundation NRP 79 – Advancing 3R: Watching the heart grow - in real time!

It is out now! Together with NRP 79 «Advancing 3R – Animals, research and society», we have produced a short video, explaining our team‘s work in the Swiss National Science Foundation SNSF‘s NRP79 program.
Video on Youtube youtu.be/0tUjkAOEpOY?...

ASIC 2025 Meeting - Wissenschaftliches Treffen über ASICs Erleben Sie die neuesten Fortschritte in der ASIC-Forschung beim ASIC 2025 Meeting in Tutzing.

Great meeting on acid-sensing ion channels coming up in the fall in Germany - make sure to sign up:

www.asic-meeting.org

Still a week or so to go. Places are starting to fill up, don’t delay!

#biophysics #SingleChannels

Sodium channels and clinical pain: join the finale of worldwide sodium channel seminar series by Janneke Hoeijmakers on June 24! Still not enough of Nav research? Safe the date for the 2nd ww Nav channel conference Feb 4 to 6, 26 in Grindelwald CH⛰️. www.sodiumchannelseminars.org

📢 Make sure to join us next week for a talk by Janneke Hoeijmakers, who will present her recent work in the field of #pain research, titled:

"Sodium channelopathies in small fiber neuropathy: from genotype to phenotype".

the link will be available here: sodiumchannelseminars.org/Program-2024...

A checklist for designing and improving the visualization of scientific data Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...

I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4

#DataVisualization #PhD #SciComm

Thx for review @bethcimini.bsky.social + 2

Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism. New Viewpoint article from Peter Hull @fau.de‬ and Angelika Lampert @lampertlab.bsky.social @rwth.bsky.social: rupress.org/jgp/article/...

#VoltageGatedNaChannels #Biophysics #IonChannels

Join this fantastic seminar today!

Slow inactivation of the fast sodium channel will be the topic of our next worldwide sodium channel seminar by Shimon Marom Tuesday May 27th on "Adaptive, slow sodium channel inactivation: impacts on neuronal excitability".
www.sodiumchannelseminars.org for link and infos. 🧠 🎓

One week till our exciting networking event in Bern🤝 Come & connect with… | 500 Women Scientists Bern-Fribourg One week till our exciting networking event in Bern🤝 Come & connect with our speakers from the life science industry👩🏼‍🔬➡️👩🏼‍💼All are welcome!

Great opportunity (free, no registration required ❗️) for those who would like to research the job opportunities in the life sciences industry 🧪🧫🧬

www.linkedin.com/posts/500-wo...

Check out this new review from #PMB Contreras Lab!

Some really nice work just out in @jmccplus.bsky.social
Congrats to the Authors!

#CardioSky

FGF14 encodes a sodium channel accessory subunit. Ransdell, Nerbonne et al. @washumedicine.bsky.social show that targeted Fgf14 deletion in mouse CA1 pyramidal neurons causes increased firing, revealing cell-type specific effects. rupress.org/jgp/article/...

#Nerve #CellularPhysiology

Join us tomorrow (May 6 at 16:00h) to the Partnered Seminar! PD Dr. Jean Sébastien Rougier from Unibe and Prof. Dr. Giulio Conte from Cardiocentro Ticino Institute Lugano will be presenting on New insights into the pathophysiological mechanisms and therapeutic targets of Brugada syndrome
#CVRCBern

My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑‍🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...

Antibodies 101: Designing Your First Flow Panel Struggling to get started with designing your first flow panel? This blog walks you through what you need to know and an example panel design to help you get started!

First time running flow cytometry, and not sure how to pick your markers? Check out the "Designing Your First Flow Panel" blog post, by Paul Heisig!

blog.addgene.org/ant...

A rich conformational palette underlies human CaV2.1-channel availability Nature Communications - CaV2.1 channels are critical for neuronal communication. Here, authors showed they undergo electrically-evoked molecular movements which (1) eventually trigger...

Out now at Nat Comm: "A rich conformational palette 🎨 underlies human CaV2.1-channel availability"
1. VSD-I activation triggers transmitter release
2. VSD-I conversion causes VDI & contributes to plasticity
3. CaV2.1 channels have several conformations at Vrest
#neuroskyence #CACNA1A
rdcu.be/ei0Tm

Happening soon!

Investigating the Functional Role of the DI-DII Linker in Nav1.5 Channel Function https://www.biorxiv.org/content/10.1101/2024.12.01.626264v1