Brandon Walther

Native nucleosomes intrinsically encode genome organization principles www.nature.com/articles/s41...
▶️Condensed purified native mononucleosomes with polyamines
▶️Nucleosomes from A compartments have low condensability and those from B compartments have high condensability

10.05.2025 19:42 — 👍 28    🔁 4    💬 1    📌 1

Check out our new preprint! (: Lead by the incredible Jonghan Park in TJ Ha's lab.

Here, we explore how DNA stores and encodes information via its mechanical properties, rather than via base pairs, and how those properties can be selected for!

www.biorxiv.org/content/10.1...

27.12.2024 00:38 — 👍 0    🔁 0    💬 0    📌 0

Delighted to share my latest work, co-first authored with fantastic undergrad mentee Joshua Lee, on highly entangled hydrogels with photolabile crosslinks. We compare selective crosslink cleavage (which lengthens chains) to non-selective photo-oxidative degradation. pubs.rsc.org/en/content/a...

09.12.2024 16:38 — 👍 20    🔁 4    💬 0    📌 1

The stiffness of cells and their nuclei is a biomarker of several pathologies, yet is usually reduced to a single value. In our last paper, we propose a method to estimate heterogeneous maps of stiffness inside freely moving cells using only fluorescence imaging.
ieeexplore.ieee.org/document/107...

25.11.2024 20:05 — 👍 19    🔁 5    💬 0    📌 0

Piezo is on the #NuclearEnvelope 😆, mediating Apoptosis caused by defects in Homologous Pairing & Synapsis (Synapsis Checkpoint) during🪱#Oocyte #Meiosis

A novel #Celegans model of Auxin-inducible proximity (instead of degradation)
@adernburg.bsky.social #Science 2024
www.science.org/doi/10.1126/...

25.11.2024 12:30 — 👍 24    🔁 3    💬 0    📌 0

JDLL: a library to run deep learning models on Java bioimage informatics platforms.
@jytinevez.bsky.social @deepIcy_IP @deepImageJ

www.nature.com/articles/s41...

23.11.2024 10:28 — 👍 23    🔁 4    💬 0    📌 0

Engineering #OrganOnAChip Systems for Vascular Diseases

Material: PDMS
+Softer polyester
+Hydrogel (or Hydrogel with topological entanglement?😁)

Atherosclerosis-on-a-chip
Thrombosis-on-a-chip
PAH-on-a-chip
Aneurysm-on-a-chip

#ATVB 2023 @ahascience.bsky.social
www.ahajournals.org/doi/full/10....

19.11.2024 13:15 — 👍 21    🔁 2    💬 0    📌 0

Matter (@mattercellpress.bsky.social) A new materials sciences journal published by @cellpressnews.bsky.social and the home for transformative research | Editor-in-Chief: Steve Cranford @cranfordmatter.bsky.social

Matter is now on bluesky! More to come soon!

mattercellpress.bsky.social

19.11.2024 15:35 — 👍 9    🔁 2    💬 1    📌 0

Global #CellVolume (not nuclear vol) Expansion drives collective invasion of #BreastCancerCell through #BasementMembrane

TRPV4- & Osmolality-dependent

Collective invasion doesn't need #Invadopodia

Ovijit Chaudhuri lab #NatureMaterials 2023
www.nature.com/articles/s41...

22.11.2023 12:17 — 👍 8    🔁 4    💬 0    📌 0

picture!

11.11.2023 16:50 — 👍 0    🔁 0    💬 0    📌 0

Disrupted stiffness ratio alters nuclear mechanosensing The nucleus has emerged as an important mechanosensor. We used a correlative atomic force microscopy/super-resolution pipeline to computationally study how the mechanical properties of the cytoplasm a...

want to share our new work (:

www.cell.com/matter/fullt...

11.11.2023 16:50 — 👍 1    🔁 1    💬 1    📌 0

hello bluesky!

11.11.2023 13:49 — 👍 5    🔁 0    💬 0    📌 0