Journal of Cell Science

Ian Ganley's pet snowflake moray eel, Eel Armstrong

By popular request, here is a portrait of Eel Armstrong:

Professor Ian Ganley, 2025 winner of the British Society for Cell Biology (BSCB) Hooke Medal

Our latest interview is with 2025 @bscb-official.bsky.social Hooke Medal winner Ian Ganley of the University of Dundee @mrcppu.bsky.social‬‬. We spoke with Ian about his career journey, his approach to mentorship and his pet snowflake moray, Eel Armstrong. journals.biologists.com/jcs/article/...

MARylating PARPs in protein trafficking and cellular stress responses. MARylating PARPs adapt their functions to restore cellular homeostasis under stress conditions.

Also in Issue 14:
- Research Highlights on COG and T cell migration
- Interview with Helen Weavers @Hm_Weavers ‪@helenweavers.bsky.social.
- Opinion article on α-tubulin K40 acetylation
- MARylating PARPs Review
journals.biologists.com/jcs/issue/13...

The image shows activated primary T cells migrating on an ICAM-1-coated surface. F-actin (phalloidin staining) is shown in cyan, phosphorylated myosin light chain in a yellow heat map, and the nucleus is in grey (DAPI).

Issue 14 is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image shows activated primary T cells migrating on an ICAM-1-coated surface. See article by Kurtz et al.
journals.biologists.com/jcs/article/...

Cytotoxic T lymphocytes adapt to loss of a key polarity factor Cytotoxic T lymphocytes (CTLs) kill infected or cancerous cells by secreting cytotoxic enzymes at the polarised immune synapse, a process called degranulation. The Rho GTPase CDC42 is crucial for cell...

You can find a great summary of the work by @jcellsci.bsky.social here: journals.biologists.com/jcs/article/...

And a profile of first author @adamrochussen.bsky.social here: doi.org/10.1242/jcs....

Huge thanks to @thecimr.bsky.social for supporting this work!

Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...

In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️

This is a useful summary of how some major publishers are responding to the new NIH policy. We've just updated our policies at @biologists.bsky.social: @dev-journal.bsky.social @jcellsci.bsky.social and @jexpbiol.bsky.social will allow authors to deposit the accepted version with zero embargo.

About our grants Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

Similarly in my field, @biologists.bsky.social funds grants to the community from publication revenues in @dev-journal.bsky.social , @jcellsci.bsky.social , and @jexpbiol.bsky.social
www.biologists.com/grants/

Schematic showing the MARylation reaction and MARylating PARPs.

In their Review, Simone Di Paola, Giovanna Grimaldi and Daniela Corda discuss the roles of mono-ADP-ribosylation catalysed by PARP enzymes in basic cell functions, as well as in viral infections and cancer.

Aranya Pal (left) and Prabin Bawali (right)

Read more about this research in our ‘First person’ interview with Aranya Pal and Prabin Bawali: journals.biologists.com/jcs/article/...

Figure showing that increased RHOA level in GECs promotes lasso formation.

Aranya Pal, Prabin Bawali, Asima Bhattacharyya and colleagues dissect RHOA-dependent regulation of mitochondrial remodelling and cell motility in hypoxia-exposed gastric epithelial cells.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish

Porncheera Chusorn

Kriengkrai Phongkitkarun

Read more about this research in our ‘First person’ interview with Kriengkrai Phongkitkarun and Porncheera Chusorn: journals.biologists.com/jcs/article/...

Schematic of the quantitative image-based analysis of cell cycle distribution and FOXM1 dynamics.

Kriengkrai Phongkitkarun, Porncheera Chusorn, Somponnat Sampattavanich and colleagues use their chemically tunable FOXM1–DHFR sensor to interrogate the influence of FOXM1 on the cell cycle.
journals.biologists.com/jcs/article/...

Tree no. 12674 Field maple (Acer campestre) Sturdy broad-leaved deciduous tree, with a wide ecological range and natural distribution over most of Europe. Field maple has a light brown and flaky bark, with brown slender twigs that develop corky ridges with age. Its small, dark-green leaves have five lobes with rounded teeth, and fade to a rich golden-yellow or red before falling in autumn. A hermaphroditic species – its small, yellow-green, clustered flowers are pollinated by insects and develop into large, winged crimson fruits (samaras) that are dispersed by wind.

This article is associated with a field maple tree, planted in The Forest of Biologists.
forest.biologists.com/landscape/

Figure showing that LC3-positive structures formed in the absence of ACSL3 are not functional autophagosomes.

Shun Kato, Mitsuo Tagaya and colleagues identify different roles for ACSL3 and ACSL4 in autophagosome formation.
journals.biologists.com/jcs/article/...

Anjali Kapoor

Read more about this research in our ‘First person’ interview with Anjali Kapoor:
journals.biologists.com/jcs/article/...

Microscopy images and accompanying quantification showing that ATP synthase epsilon subunit is involved in Hb endocytosis in Leishmania.

Anjali Kapoor, Amitabha Mukhopadhyay and colleagues discover that ATP synthase epsilon subunit is an unconventional adaptor in clathrin-mediated endocytosis of hemoglobin in Leishmania.
journals.biologists.com/jcs/article/...

Liz Kurtz

Read more about this research in our ‘First person’ interview with Liz Kurtz @liz-kurtz.bsky.social:
journals.biologists.com/jcs/article/...

Liz Kurtz @liz-kurtz.bsky.social, Nathan Roy and colleagues find that the scaffold protein CasL restrains membrane blebbing and promotes T cell migration.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

Monika Jaiswal

Read more about this research in our ‘First person’ interview with Monika Jaiswal:
journals.biologists.com/jcs/article/...

Monika Jaiswal, Sorab Dalal and colleagues find that 14-3-3ε inhibits premature centriole disengagement by inhibiting the activity of Plk1 and separase.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish

Ping-Shuang Lu

Read more about this research in our ‘First person’ interview with Ping-Shuang Lu:
journals.biologists.com/jcs/article/...

Figure showing that CLASP1 regulates spindle organization and central spindle formation in mouse oocytes.

Meng-Meng Shan, Ping-Shuang Lu, Shao-Chen Sun and colleagues discover that CLASP1 regulates DYNC1I1 for PLK1-mediated spindle organisation and cytokinesis in oocyte meiosis.

journals.biologists.com/jcs/article/...

Had a GREAT experience with this earlier this year. Highly recommend.

I’ll be presenting this work (and a bunch of unpublished data) at 2.45pm at the #yeast2025 conference 🤓

This collaboration with @merusadhu.bsky.social has also benefitted from the meeting, as we planned more experiments on the river last night 👌

Have a paper that's been reviewed elsewhere? JCS is pleased to consider such manuscripts for 'fast-track' decisions. Send us the manuscript together with the full set of reviews and decision letters, and we’ll use these to make a decision.
Find out more:
journals.biologists.com/jcs/pages/re...

Helen Weavers

Our latest interview is with 2025 @bscb-official.bsky.social WICB early career medal winner Helen Weavers @helenweavers.bsky.social‬. We hear about what winning the award means to Helen, her research and her advice on staying resilient.
journals.biologists.com/jcs/article/...

Schematic showing the effect of acetylation on microtubule nucleation, microtubule elongation and shrinkage.

In this Opinion article, Yu-Ming Lu discusses multiple important studies on microtubule acetylation with the aim of clarifying the actual role of α-tubulin K40 acetylation, a major tubulin post-translational modification.
journals.biologists.com/jcs/article/...

MatriCom – the extracellular matrix reloaded The extracellular matrix (ECM) is made up of hundreds of proteins, including structural core ‘matrisome’ proteins, factors that associate with and regulate ECM architecture and dynamics, and ECM recep...

Thank you @jcellsci.bsky.social for featuring our article in your #Highlight section! MatriCom – the extracellular matrix reloaded url: journals.biologists.com/jcs/article/... @matrisome.bsky.social @valerioizzi.bsky.social

Hatwan Nadir

Read more about this research in our ‘First person’ interview with Hatwan Nadir: journals.biologists.com/jcs/article/...