Journal of Cell Science (@jcellsci) — Bluesky Profile

1 day ago

Visit our fully accessible journal archive, providing perpetual access to 34k articles from over a century of pioneering research in developmental biology, cell biology, comparative physiology and biomechanics, including work from 60+ Nobel Prize-winners bit.ly/3PfIjib

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1 day ago

Read & Publish for researchers Read & Publish agreements offer many benefits to researchers including fee-free Open Access publishing in Development, Journal of Cell Science and Journal of Experimental Biology.

This article is available under our Read & Publish Open Access initiative.
Researchers can find out about the wide range of benefits, read what researchers are saying and view a list of participating institutions at www.biologists.com/library-hub/...
#OpenAccess #ReadandPublish

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1 day ago

Figure showing that increased mechanical tension weakens IFM attachment.

Dylan Feist, Erika Geisbrecht and colleagues find that Transglutaminase in the ECM helps glue Drosophila muscles to tendons.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

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Read more about this research in our ‘First person’ interview with Gisela Cairo and Muhammad Abdul Haseeb: journals.biologists.com/jcs/article/...

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Gisela Cairo @giselacairobaza.bsky.social, Muhammad Haseeb @muhammad-haseeb.bsky.social, Soni Lacefield @lacefieldlab.bsky.social & team find that the MOS-MAPK pathway regulates polar body fate in mouse oocytes.
journals.biologists.com/jcs/article/...

journals.biologists.com/jcs/article/...

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3 days ago

JCS poster: DNA double-strand break response at a glance by Francesca Esposito and Sofia Francia.

In their Cell Science at a Glance article & poster, Francesca Esposito & Sofia Francia explore the interplay between local & global chromatin changes in response to DNA double-strand breaks that ensure damage signalling, halt transcription & coordinate repair.
journals.biologists.com/jcs/article/...

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3 days ago

Associate Editor of @jcellsci.bsky.social, @ckirchhelle.bsky.social, explains directional growth control in plant roots. Using a computational model, Charlotte shows that surface root cells bear max. tension, making them sensitive to deformation unless mechanically shielded or reinforced. #gfe2026

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4 days ago

Tree no. 16583
Small-leaved lime (Tilia cordata)
Large deciduous tree found in woodland, native to England, Wales, and central and eastern Europe. It has heart-shaped leaves with the lower surface containing reddish hairs in the vein axils. Lime blossoms are hermaphroditic green-yellow flowers with five petals, with a rich sweet scent attracting insects, especially bees. Flowers develop into large-winged, nut-like fruits and the seeds are dispersed by wind.

This article is associated with a small-leaved lime tree, planted in The Forest of Biologists.
forest.biologists.com/landscape/

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4 days ago

Figure showing the differential interactome of PA200 in lung cancer cell lines.

Ayse Yazgili @yazgili.bsky.social, Silke Meiners & colleagues find that PA200 exerts cell-specific functions in lung cancer cells but a shared feature is promotion of tumour cell invasion adding to the poor prognosis of PA200-overexpressing NSCLC individuals.
journals.biologists.com/jcs/article/...

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5 days ago

Also in Issue 4:
- Research Highlights on force transmission, mitosis and actin segmentation
- Perspective article on cryo-EM in structural biology
- DNA double-strand break response at a glance
journals.biologists.com/jcs/issue/13...

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5 days ago

JCS cover: Actin forms a supracellular network at the apical side of squamous epidermoid cells. Actin filaments are colour-coded according to their position along the z-axis, revealing the three-dimensional organization and continuity of the apical actin cortex across neighbouring cells. See article by L. Marpeaux et al. (jcs264424).

Issue 4 is complete

Explore our Toc: journals.biologists.com/jcs/issue/13...

Our cover image shows the apical supracellular actin network in squamous epidermoid cells. Actin filaments are colour-coded according to z-position. See article by Marpeaux et al.
journals.biologists.com/jcs/article/...

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Read more about this research in our ‘First person’ interview with Nickhil Jadav: journals.biologists.com/jcs/article/...

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(A) 3D reconstruction of a mitotic cells from prophase to cytokinesis, highlighting the cell membrane (grey), nucleus (blue) and chromosomes (purple). (B) Metaphase cell superimposed on a z-stack slice showing chromosomal volumetric progression; descending shades of purple denote size (large, >3 μm3; medium, 2–3 μm3; small: <2 μm3), with sex-linked chromosomes in dark pink.

Nickhil Jadav, Sailakshmi Velamoor, Duane Harland, Mihnea Bostina and colleagues use volume electron microscopy to uncover mitotic ultrastructure in the native hair follicle.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#cellbio #volumeEM #vEM

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1 week ago

OptoLoop – an optogenetic tool to probe the functional role of genome organization Summary: The development of OptoLoop – an optogenetic tool to induce chromatin looping in a controlled fashion using light and how this tool can be applied to study genome structure–function relations...

Want to try our new OptoLoop constructs for optogenetic control of chromatin looping?

Check out our plasmids now available at @addgene.bsky.social

www.addgene.org/browse/artic...

And don't forget to read our new article published in @jcellsci.bsky.social

journals.biologists.com/jcs/article/...

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1 week ago

Very proud to share our latest work, carried out with remarkable dedication by Léa and Claire.
Thanks to JCS for the Highlight, but also the wonderful First Author profile featuring Léa and Claire, as well as the journal cover showcasing the work.

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1 week ago

New JCS snapshot - Redefining colocalization analysis with a novel phasor mixing coefficient

Owen Puls @owfpuls.bsky.social presents the key findings from their recent JCS paper with Teng-Leong Chew @scopeshifu.bsky.social @hhmijanelia.bsky.social and team.
journals.biologists.com/jcs/article/...

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Workflows for assigning proteins to unknown densities in cryo-EM maps. (A) For high-resolution regions, a backbone model is built into the map. Side chain densities at each position are assessed and used to query a sequence database to find the most likely candidate. Alternatively, the backbone model can be used to directly query a structure database to find proteins with similar folds. (B) For medium-resolution regions, a library of known or predicted structures can be rigid body-fitted into the map. The fits can be scored and ranked or otherwise assessed to determine the best fit. Images in B are published from Leung et al., 2025, where they were published under CC-BY 4.0 terms.

In this Perspective article, Miguel Ricardo Leung discusses how advancements in cryo-electron microscopy and machine learning-based structure prediction are enabling a ‘structure-first approach’ for discovering new proteins and interactions.
journals.biologists.com/jcs/article/...

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1 week ago

In this Perspective article, Miguel Ricardo Leung discusses how advancements in cryo-electron microscopy and machine learning-based structure prediction are enabling a ‘structure-first approach’ for discovering new proteins and interactions.
journals.biologists.com/jcs/article/...

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1 week ago

Why propose a topic for one of our Workshops? YouTube video by The Company of Biologists

Getting involved as an organiser of one of our Workshops is easy. We focus on the logistics, so you can focus solely on the science. Watch this video to hear from some of our previous organisers. The call for proposals for 2028 programme runs until 29 May. www.youtube.com/watch?v=eShr...

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1 week ago

Read & Publish for researchers Read & Publish agreements offer many benefits to researchers including fee-free Open Access publishing in Development, Journal of Cell Science and Journal of Experimental Biology.

This article is available under our Read & Publish Open Access initiative.
Researchers can find out about the wide range of benefits, read what researchers are saying and view a list of participating institutions at www.biologists.com/library-hub/...
#OpenAccess #ReadandPublish

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1 week ago

$Workflow of the protein purification process in the Cyanidioschyzon-based protein purification system. (A) Schematic overview of the protocol for recombinant protein isolation using the Cyanidioschyzon-based protein purification system. (B) Representative images showing a 0.7-l culture in a glass bottle (left), harvested cell pellet (middle) and resulting cell lysate (right). (C) Microscopy image of disrupted cells following a single freeze–thaw cycle. Images are representative of more than three independent experiments. (D) IMAC of 6×His-tagged mVenus from the cell lysate. (E) SDS-PAGE analysis of the cell lysate (Cell), supernatant (Sup) and cell debris pellet (Pellet), IMAC elution fractions, and a dialyzed sample from fractions #5 and #6. For the Cell, Sup and Pellet samples, 20 μg of total protein was loaded per lane. For the IMAC elution fractions and the dialyzed sample, 10 μl of each was loaded. Data in D and E representative of three experimental repeats.$

In their Tools and Resources article, Yuko Mogi, Yamato Yoshida and colleagues present their recombinant protein expression platform with simplified purification based on the photosynthetic unicellular red alga Cyanidioschyzon merolae.
journals.biologists.com/jcs/article/...

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Read more about this research in our ‘First person’ interview with Léa Marpeaux and Claire Baudouin: journals.biologists.com/jcs/article/...

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Léa Marpeaux, Claire Baudouin, Gregory Emery @emery-lab.bsky.social and colleagues @umontreal.ca identify an apical supracellular actin network in epithelial cells that acts as a long-range force transmission device.

journals.biologists.com/jcs/article/...

journals.biologists.com/jcs/article/...

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1 week ago

preLights in cell biology (February 2026) This article includes recent preLight posts that discuss preprints in the field of cell biology.HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton by Olivier Mercey et al.Read the featu...

preLights in cell biology: February edition

journals.biologists.com/jcs/article/...

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2 weeks ago

Cartoon of Mole looking happy having fallen into deep snow after skiing off a slope with exclamation marks over Mole’s head. An anthropomorphised teapot with sunglasses and skis is looking on saying, “Mole!!! We are NOT here for fun!!”

Are we having fun yet?

Read the latest from Mole: journals.biologists.com/jcs/article/...

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2 weeks ago

Super excited that my PhD paper is now officially published - and even more thrilled that my neurons made the cover image of the issue!

doi.org/10.1242/jcs.26…

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Phospholipid chemical structures. (A) Glycerophospholipids in archaea feature ether-linked isoprenoid chains and a G1P backbone, in contrast to bacterial and eukaryotic phospholipids, which use a G3P backbone. (B) Phospholipids in eukaryotes are composed of a glycerol (left) or sphingosine (right) backbone, a hydrophilic head group, and one or more hydrophobic acyl chains. Classical glycerophospholipids and sphingophospholipids typically comprise two acyl chains. Although the head groups of glycerophospholipids are highly variable, the most commonly observed head groups of sphingophospholipids are phosphate, phosphocholine and phosphoethanolamine. The fatty acyl chains are typically attached to the glycerol backbone via ester linkages, and the single fatty acid chain is attached to the amino group of the sphingosine backbone via an amide linkage. The top and middle carbons of the glycerol backbone are indicated by sn-1 and sn-2, respectively. (C) Head groups, linkages and acyl chains can vary to create a diverse range of phospholipid structures. The nomenclature used for acyl chains, such as (16:0) and (18:1, n-9), represents the fatty acyl chain structure as (C:D), where C is the total number of carbon atoms, D is the number of double bonds, and the optional ‘n’ indicates the position of the first double bond counted from the methyl end of the chain. (D) Distinct phospholipid subclasses that differ from this structure include lyso-phospholipid, which contains only one fatty acid chain; bis(monoacylglycero)phosphate, which contains two monoacylglycerol units; and cardiolipin, which is characterized by four acyl chains with two phosphatidyl moieties (Harayama and Riezman, 2018).

Also in Issue 3:
- Research Highlights on cardiomyocytes, CVM migration, endolysosomal identity & astrocyte cytoskeletal dynamics
- Correspondences on the LECA debate
- Adaptive regulation of glycerophospholipid metabolism Review
- preLights in cell biology
journals.biologists.com/jcs/issue/13...

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2 weeks ago

JCS Cover: The image shows human induced pluripotent stem cell-derived neurons immunostained for LAMP2 (red) and the neuronal marker TUJ1 (blue) and expressing LAMP1–EGFP (green; detected by anti-GFP immunostaining). LAMP1 and LAMP2 are members of the same protein family and are commonly used interchangeably to label lysosome-like organelles. However, new findings indicate that they localise to functionally distinct organelles, and this image highlights the heterogeneity of the neuronal endolysosomal system. See article by R. Abouward et al. (jcs264466).

Issue 3 is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

On the cover: hiPSC-derived neurons labelled with TUJ1 (blue), LAMP1 (green) & LAMP2 (red). The image highlights the heterogeneity of the neuronal endolysosomal system.
journals.biologists.com/jcs/article/...

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2 weeks ago

It’s FREE to publish in Journal of Cell Science – there are no page charges, colour charges or hidden fees. And if your institution has a Read & Publish agreement, you can publish immediate OA free of charge.

Find out more: journals.biologists.com/jcs/pages/re...

#forscientists
#notforprofit

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2 weeks ago

Are we having fun yet? Hey there! Yes, it's your old pal, Mole (emphasis on the old). It's a cold and blustery day, and I'm taking a little time off to have this chat with you, because, well, it's been a while. I hope you'r...

Are we having fun yet? *
journals.biologists.com/jcs/article/...

* Does Mole have an ORCiD yet @jcellsci.bsky.social ?

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