Tyler Pearson

In short, if you want to give your chemistry the best chance for reproducibility, use overhead stirring.

Even after just a few months working in a group dedicated to scale up and process transfer, this absolutely tracks. If your reaction is at all heterogeneous, it's likely there is a strong mixing component at play that will affect the chemistry across different batch sizes if not controlled.

It's not a solution per se, but I've been making homemade yogurt for a couple years now and have not bought it from the store since. Everyone I tell is really surprised at it, but it's actually extremely simple, especially if you have an instant pot.

There's a difference between AI being used to analyze well curated datasets and "gen-AI" which is being broadly peddled as the next big thing. The former has been in use for the societally useful things you mentioned far longer than chatGPT has been around too.

If a drug doesn't make it to market then the company has no way to recoup the substantial amount of money spent developing that drug candidate. So think of it as the successful drugs (<<1% of all drug candidates) subsidizing research into the entire rest of the company's pipeline.

Oh yeah there's plenty of opportunism out there to be sure! But I'd just push back on discounting a whole field because it's occasionally over-hyped.

That's a pretty cynical way of looking at it. There's tons of value in optimizing older results and turning them into useful methods. Just because it showed up in a 1970s paper doesn't mean it's a reaction that someone would actually use.

Obviously you should only do so with proper acknowledgement

Boring chemistry is great! I also think further emphasis should also be put on techniques that use quotidian "off the shelf" materials. The barrier to me trying chemistry I'm not 100% sure about is wayyy lower if I don't have to wait for/make a fancy ligand/reagent.

Where's the dislike button on here 😔

Back when I was an undergraduate we had a laptop repair/loaner system for situations like that. If your computer crapped out for whatever reason you could bring it to them and they'd fix it for just the cost of parts. Granted we also had well equipped computer labs as well.

Proposing this as a solution to poor pharmaceutical availability is like proposing burning down your house to get rid of bed bugs. This "solution" will literally kill people.

Haber Bosch process, water gas shift reaction, Ziegler Natta - big industrial processes basically.

Lanthanide mining/separation is an interesting one too

The chimney swifts have arrived in force here in #Chicago! No good photos yet but they've maybe even supplanted the sparrows as the most-heard calls in the neighborhood

#birds

A male downy woodpecker looking off to the side while perched on a tree

A downy woodpecker looking off to the distance. One imagines pensively?

A common yellowthroat in the brush

A black and white warbler perched on a tree

A productive afternoon yesterday at Montrose Point Bird Sanctuary! Lots of people out sharing sightings with each other which was so nice!

Some photo highlights for me were this *dramatic* downy woodpecker, a very cooperative common yellowthroat, and a lovely black and white warbler.

#birds

took a swing past Jackson Park and had some fun sightings - a Caspian tern swooping over the lagoon, a grey-blue gnatcatcher, an orange-crowned warbler (I think!), and a northern flicker, among others

#birds

#birds

A photo of a peregrine falcon flying over grass with Lake Michigan in the background

A common yellowthroat perched on a dead branch

A yellow warbler perched in a flowery tree

A black-capped chickadee perched on a branch

Visited Montrose Point Bird Sanctuary today and was not disappointed - got some beautiful shots of a yellow warbler, a black capped chickadee, a female downy woodpecker, and a common yellowthroat, and a less beautiful shot of a peregrine falcon (!!) in flight!

#addbirder

Thank you!

A song sparrow eating a dragonfly

A sparrow sitting in a budding tree with a patch of marram grass and Lake Michigan in the background

Took my camera out for a spin at the beach. These were two of my favorite captures. I saw sparrows (song, house, and field sparrows), mourning doves, robins, red winged blackbirds, gulls, , ducks, cormorants, and, of course, pigeons on this particular outing.

there's a slippery slope between wondering what bird that is you're seeing to impulse-buying hundreds of dollars of camera equipment

Eminem dashes

Capping those fees — possibly as low as $3 — would be a huge boon to families who really need the help. Who could oppose that?

Who indeed? 🙃

Things are getting tense over on the chemistry faculty search status tracker. Stay kind to yourselves!

Tips for succeeding in a chem class TL;DR:

1. Schedule weekly support
2. Expose yourself to the content early & often
3. “Chemistry is learned w/ a pencil in your hand.”
4. Reflect to seek out support
5. Reminder that your ability is changeable!

#chemsky

In Chicago there's a well known New Haven pizza place (called Piece) that the Yale club of Chicago caters for local events. Can confirm it matches up pretty well!

What a huge honor to have our chemistry featured on In the Pipeline!

Atoms swap spots in aromatic rings New reaction replaces carbon with nitrogen

These skeletal editing papers are so much fun to write about. I spoke to @levinchem.bsky.social and @tylerpearson.bsky.social for @cenmag.bsky.social about their aromatic atom swap.

Lots of chemistry in Science this week! First up, @levinchem.bsky.social group turn aryl azides into pyridines with precise regioselectivity using a well-chosen oxidant www.science.org/doi/full/10....

Chemsky 🧪

I owe a lot to my amazing coworkers, co-authors, and advisor @levinchem.bsky.social

I came to the Levin group as an inorganic chemist with no practical experience in developing organic reactions.

They took a chance on me and gave me the ideal environment to grow into the chemist I am today.

Today it's my pleasure to present my magnum opus from my time in the Levin group: a site-selective benzene-to-pyridine "transmutation"

Now, you can replace carbon atoms in benzene rings with a nitrogen with intuitive and predictable site selectivity!

Read it here: www.science.org/doi/full/10....