Jolene Ramsey

Bacteroides expand the functional versatility of a conserved transcription factor and transcribed DNA to program capsule diversity - Nature Communications Bacteroides strains have multiple operons for biosynthesis of diverse capsular polysaccharides, but most cells express only one operon at a time due to tight regulation of transcription elongation by ...

Jason Saba, Sternberg Awardee: #Bacteroides fragilis varies its cell surface with 8 capsular polysaccharide operons but only expresses 1 polysaccharide at a time using the combination of invertible promoters and a UpxY-UpxZ hierarchical regulatory program
#phages2025 🦠
www.nature.com/articles/s41...

Intraspecific bacterial competition mediated by rapidly diversifying tailocin and prophage loci Signatures of selection in microbial genomes are often linked to biotic interactions, notably resistance to host immunity or bacteriophage attack. Here, we highlight the importance of competitive inte...

Emmanuel Allwell: #Xenorhabdus nematophila tailocins display common heterospecific killing but vary in conspecific killing; susceptibility profiles of strains to lysates were associated with O-antigen biosynthesis genes #phages2025 🦠

www.biorxiv.org/content/10.1...

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides Cyclic-oligonucleotide-based anti-phage signaling system (CBASS) is a common immune system that uses cyclic oligonucleotide signals to limit phage rep…

Iana Fedorova: Acb2 sequesters nearly all known CBASS signaling molecules through two distinct binding pockets and therefore serves as a broad-spectrum “sponge” inhibitor of cGAS based innate immunity #phages2025 🦠

www.sciencedirect.com/science/arti...

@femtokot.bsky.social

some call it thick skin
protection from cyclic storms
maybe pack your sponge

#sciku 🧪🧬🔬🧫🦠 #Phages2025
@jbdsf.bsky.social lab

Emmanuel Allwell

homing sword disarmed
shields with doodads added on
match them up to know

#sciku 🧪🧬🔬🧫🦠 #Phages2025
@hgblair.bsky.social lab

Emma Wiesler

interpreting maps
squiggles, shadows, there’s the X
legend key conserved

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Genevieve Dobihal

the windy path leads
virulence signature found
matters in hosts too

#sciku 🧪🧬🔬🧫🦠 #Phages2025

@pseudo-mona.bsky.social

lil’ buddies poppin’
up, but evading ID
why make life hard? (fun!)

#sciku 🧪🧬🔬🧫🦠 #Phages2025

artistic license
use your imagination
see science in words

Michael Cadigan

feed cookie monster
open can lid, stuff cookies
can bigger than thought

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Nasibeh Arabameri

organic divides
neighborhoods with character
some more violent

#sciku 🧪🧬🔬🧫🦠 #Phages2025

@btsenglab.bsky.social lab

Vivian Zhang

an annoying “phly”
block with temporary wall
keeps gut balance tuned

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Ciara Sanders

if homogenized
lose rich regional flavors
microbes may drive it

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity Bacteria orchestrate multiple promoter inversions to coordinate population diversity.

Jason Saba, Sternberg awardee

backflips landed right
trip all paralogs
domination set

#sciku 🧪🧬🔬🧫🦠 #Phages2025
doi.org/10.1126/scia...
doi.org/10.1038/s414...
doi.org/10.1038/s415...

Chase Mullins

QS light after
integrate signals galore
sort out that crosstalk

#sciku 🧪🧬🔬🧫🦠 #Phages2025

@kevinengland.bsky.social

some less P on G
synthesis goes down— but why?
indirect, or not

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Rilee Zeinert

small protein active
tapped into regulation
sideways levels down

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Phage Mu Utilizes the Sliding Clamp for Late Gene Transcription MuC, along with core RNAP and σ70, is required for transcription of late genes of phage Mu. We observed that overexpression of MuC is lethal in E. coli and that host replication was over-initiating un...

Khang Ho

pull favor away
phage co-opts host clamp for self
Mu transcribe away!

#sciku 🧪🧬🔬🧫🦠 #Phages2025
www.biorxiv.org/content/10.1....

Ezaz Ahmad

pausing is normal
see more outside cell routine
marathon and sprints

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Streptomyces uses both polar and dispersed cell wall synthesis during exploratory growth - Nature Microbiology Streptomyces venezuelae requires MreB1-dependent dispersed peptidoglycan cell wall synthesis and DivIVA-mediated polar cell wall synthesis during its rapid exploratory growth phase.

#Streptomyces venezuelae uses an MreB-dependent lateral elongation growth mode during exploratory growth - publication drop mentioned during #phages2025 🦠

www.nature.com/articles/s41...

@thalia.bsky.social: the transcription factor “stringent starvation protein” SspA is an important regulator of AZT(DNA damage)-induced genes #phages2025 🦠

www.pnas.org/doi/10.1073/...

Divya Seerpatham

don’t fix if not broke
limit access by fixers
grounded during change

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Taylor Nye

best to take a NAPP:
CATNAPP, refreshed can ID
all partners bound there

#sciku 🧪🧬🔬🧫🦠 #Phages2025

@scotthultgren.bsky.social lab

Streptomyces uses both polar and dispersed cell wall synthesis during exploratory growth - Nature Microbiology Streptomyces venezuelae requires MreB1-dependent dispersed peptidoglycan cell wall synthesis and DivIVA-mediated polar cell wall synthesis during its rapid exploratory growth phase.

Christine Baglio

streptomyces growth
balancing expansion out
sustain defense too

#sciku 🧪🧬🔬🧫🦠 #Phages2025
hot off the press: doi.org/10.1038/s415...

Marie Elliot

exposing repressed
compound clusters make new drugs
unique binding sites?

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Morgan Letzkus

rules inherited
but, asked to pick up loose slack
restore order please

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Runhang Shu

thought phage did not care
fifty percent preference
packaging surprise?

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Jonathan Lombardino

patches interrupt
diversity across bug
maybe this is why?

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Micah Ferrell

balance on and off
bind tuned molecular pools
live without panic

#sciku 🧪🧬🔬🧫🦠 #Phages2025

Leah McKinney

intrinsic ox on
G, stress just go away
accord in tube/cell

#sciku 🧪🧬🔬🧫🦠 #Phages2025