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Dimple Notani

@dimplenotani.bsky.social

Associate Professor, NCBS, Bangalore. Interested in signaling driven gene regulation, enhancers, genome organisation, RNA

174 Followers  |  230 Following  |  8 Posts  |  Joined: 12.11.2024  |  1.4668

Latest posts by dimplenotani.bsky.social on Bluesky

A huge thanks to the lead author Rajat Mann, Deepanshu Soota and a great collaboration with Gunjan Mehta lab. This research was made possible by support from India Alliance DBT-Wellcome and @ncbsbangalore.bsky.social @embo.org

25.12.2025 02:44 — 👍 1    🔁 0    💬 0    📌 0

Our data suggests a universal mechanism: RNA acts as a molecular "glue." By stabilizing TFs at suboptimal DNA motifs, RNA fine-tunes the activity of regulatory elements across the genome, whether they are enhancers or promoters.

25.12.2025 02:44 — 👍 0    🔁 0    💬 1    📌 0
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Once stabilized at the promoter, ERα enhances H3K27ac, priming the promoter, setting the stage for robust transcriptional burst upon the release of the paused polymerase.

25.12.2025 02:44 — 👍 0    🔁 0    💬 1    📌 0

In our new manuscript, we expand this paradigm to promoters. We found that TFs can utilize nascent RNA associated with paused RNA polymerases at the promoter to stabilize the binding of ERα
nature.com/articles/s41... 🧵

25.12.2025 02:44 — 👍 0    🔁 0    💬 1    📌 0
Preview
RNA fine-tunes estrogen receptor-alpha binding on low-affinity DNA motifs for transcriptional regulation - The EMBO Journal Transcription factors (TFs) regulate gene expression by binding with varying strengths to DNA via their DNA-binding domain. Additionally, some TFs also interact with RNA, which modulates transcription...

Classically, TFs are known to bind enhancers to drive gene expression. We previously found that even at "weak" DNA motifs, ERα can achieve stable occupancy. The secret? Interaction with enhancer RNA (eRNA) (link.springer.com/article/10.1...)

25.12.2025 02:44 — 👍 1    🔁 0    💬 1    📌 0
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Glad to share our latest work that came out recently. We dive into the mechanisms of how Transcription Factors (TFs) like the nuclear receptor, ERα navigate the genome to find their targets.

25.12.2025 02:44 — 👍 18    🔁 8    💬 3    📌 0
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The deadline for common entrance exam (JGEEBILS) for I-PhD and PhD is on 26th October. Please apply! @ncbsbangalore.bsky.social @tifr.res.in

19.10.2025 03:12 — 👍 1    🔁 0    💬 0    📌 0
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Join us for the 2025 GRC Genome Architecture www.grc.org/genome-archi... @spp2202.bsky.social @jobdekker.bsky.social @metorrespadilla.bsky.social @jopkind.bsky.social @dimplenotani.bsky.social @stanleyqilab.bsky.social @andybelmont.bsky.social @fondufemittendorf.bsky.social @boyanbonev.bsky.social

09.03.2025 23:08 — 👍 30    🔁 12    💬 0    📌 0
Congratulations Dr Rajat Mann from dr dimple notani lab at NCBS, Bangalore for succesfull thesis defence . Thesis titled " RNA provides specificity to transcription factor binding and condensate dynamics" NCBS, Bengaluru , National centre for biological sciences, bangalore

Congratulations Dr Rajat Mann from dr dimple notani lab at NCBS, Bangalore for succesfull thesis defence . Thesis titled " RNA provides specificity to transcription factor binding and condensate dynamics" NCBS, Bengaluru , National centre for biological sciences, bangalore

#PhDone! 🎓 Congratulations Dr Rajat! 🎉

Rajat Mann from Dr Dimple Notani's lab successfully defended his thesis!

🧵⬇️Scroll to know more about his work on transcription regulation 🧬
@dimplenotani.bsky.social
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11.02.2025 07:59 — 👍 7    🔁 1    💬 1    📌 0

Thanks @ncbsbangalore.bsky.social for featuring our research

10.02.2025 12:04 — 👍 1    🔁 0    💬 0    📌 0
Title: Meet Superwoman Dimple Notani! Publisher: NCBS, Tinkle Issue #821 (February 2025) This comic introduces Dimple Notani, a scientist studying gene regulation, through engaging illustrations and dialogue. Panel 1: An elephant, a monkey, and a woman stand in a green outdoor setting. The elephant says, "I’m big and I have a trunk." The monkey, swinging from a tree, adds, "I have long arms that help me swing from trees." The woman, dressed in an orange shirt and blue jeans, says, "I walk on two legs and don’t have a trunk or long arms. We are so different! Yet, our DNA is 98% similar!" This highlights genetic similarities despite physical differences. Panel 2: A scientist in a white lab coat and glasses stands with the group. She explains, "We all have a genetic code—our DNA. It contains instructions that determine height, eye color, behavior, and more." The characters listen attentively. Panel 3: The scientist introduces DNA’s four building blocks: A, T, G, and C. A diagram shows how these nucleotides pair. She explains, "These letters are in all DNA. Their arrangement creates differences between species. When their order changes, they form different ‘words’ and ‘sentences,’ leading to changes in us." A footnote clarifies that nucleotides are DNA’s building blocks. Panel 4: In a lab, a digital display of a DNA helix is shown. The scientist, joined by her students in lab coats, says, "We study DNA’s ‘sentences’ to understand genetic differences." A student adds, "Our field of study is gene regulation." This educational comic explains DNA and gene regulation through engaging visuals and simple analogies, emphasizing how genetic codes shape living beings. Continued to page 2

Title: Meet Superwoman Dimple Notani! Publisher: NCBS, Tinkle Issue #821 (February 2025) This comic introduces Dimple Notani, a scientist studying gene regulation, through engaging illustrations and dialogue. Panel 1: An elephant, a monkey, and a woman stand in a green outdoor setting. The elephant says, "I’m big and I have a trunk." The monkey, swinging from a tree, adds, "I have long arms that help me swing from trees." The woman, dressed in an orange shirt and blue jeans, says, "I walk on two legs and don’t have a trunk or long arms. We are so different! Yet, our DNA is 98% similar!" This highlights genetic similarities despite physical differences. Panel 2: A scientist in a white lab coat and glasses stands with the group. She explains, "We all have a genetic code—our DNA. It contains instructions that determine height, eye color, behavior, and more." The characters listen attentively. Panel 3: The scientist introduces DNA’s four building blocks: A, T, G, and C. A diagram shows how these nucleotides pair. She explains, "These letters are in all DNA. Their arrangement creates differences between species. When their order changes, they form different ‘words’ and ‘sentences,’ leading to changes in us." A footnote clarifies that nucleotides are DNA’s building blocks. Panel 4: In a lab, a digital display of a DNA helix is shown. The scientist, joined by her students in lab coats, says, "We study DNA’s ‘sentences’ to understand genetic differences." A student adds, "Our field of study is gene regulation." This educational comic explains DNA and gene regulation through engaging visuals and simple analogies, emphasizing how genetic codes shape living beings. Continued to page 2

Title: Meet Superwoman Dimple Notani! (Page 2) Publisher: NCBS, Tinkle Issue #821 (February 2025) This page continues introducing Dr. Dimple Notani and her passion for decoding DNA. Panel 1: A surreal scene features an elephant with tiger stripes, a monkey with a trunk, and a tiger walking upright like a human and a woman with one half of her hair curly and the other half straight. Dr. Notani explains, "There is a reason an animal looks and behaves in certain ways. We don’t often question how it all works. Decoding this is my passion." Panel 2: Dr. Notani, in a lab coat, speaks to two colleagues. She says, "Decoding DNA is like finding the secret language of life. It helps us understand why some people get diseases and some don’t, helping prevent or treat them." She holds a folder while explaining. Panel 3: A young girl observes tadpoles and wonders, "How do they become frogs?" An inset of Dr. Notani states, "I didn’t always know I would have such an awesome job." Another inset adds, "Even though I wasn’t always good at studies, I was fascinated by animals and insects." Panel 4: A younger Dr. Notani, excited, thinks, "I have to tell my professors about this discovery!" She explains, "My curiosity turned into a passion for understanding differences. My school teacher encouraged me to pursue science. Despite hardships, I became my family’s first graduate and scientist." Panel 5: Dr. Notani shares, "My postdoctoral mentor, Michael Geoff Rosenfeld, inspired me. I now encourage young people to pursue science. No matter the challenges, you’ll find a way past them!" A note clarifies "Studies done after PhD." The comic concludes: "Dimple Notani is associated with the National Centre for Biological Sciences, Bengaluru."

Title: Meet Superwoman Dimple Notani! (Page 2) Publisher: NCBS, Tinkle Issue #821 (February 2025) This page continues introducing Dr. Dimple Notani and her passion for decoding DNA. Panel 1: A surreal scene features an elephant with tiger stripes, a monkey with a trunk, and a tiger walking upright like a human and a woman with one half of her hair curly and the other half straight. Dr. Notani explains, "There is a reason an animal looks and behaves in certain ways. We don’t often question how it all works. Decoding this is my passion." Panel 2: Dr. Notani, in a lab coat, speaks to two colleagues. She says, "Decoding DNA is like finding the secret language of life. It helps us understand why some people get diseases and some don’t, helping prevent or treat them." She holds a folder while explaining. Panel 3: A young girl observes tadpoles and wonders, "How do they become frogs?" An inset of Dr. Notani states, "I didn’t always know I would have such an awesome job." Another inset adds, "Even though I wasn’t always good at studies, I was fascinated by animals and insects." Panel 4: A younger Dr. Notani, excited, thinks, "I have to tell my professors about this discovery!" She explains, "My curiosity turned into a passion for understanding differences. My school teacher encouraged me to pursue science. Despite hardships, I became my family’s first graduate and scientist." Panel 5: Dr. Notani shares, "My postdoctoral mentor, Michael Geoff Rosenfeld, inspired me. I now encourage young people to pursue science. No matter the challenges, you’ll find a way past them!" A note clarifies "Studies done after PhD." The comic concludes: "Dimple Notani is associated with the National Centre for Biological Sciences, Bengaluru."

#NewComicAlert!
Our latest comic with Tinkle Comics Studio featuring the inspiring story of Dr Dimple Notani is out now!
Dimple is an Associate Professor at NCBS studying gene regulation.

Check it out and let us know your thoughts in the comments below!
#sciencecomics
@dimplenotani.bsky.social

10.02.2025 11:28 — 👍 10    🔁 4    💬 1    📌 1
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Had a wonderful time discussing chromatin when some friends visited IIT Bombay, Mumbai! @vram142.bsky.social @dimplenotani.bsky.social @kaushikr.bsky.social

09.01.2025 15:28 — 👍 7    🔁 2    💬 0    📌 0

@dimplenotani is following 20 prominent accounts