Climate Change and Maternal Child Health Lab

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this!

And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!

www.cell.com/developmenta...

02.12.2025 13:47 — 👍 43    🔁 23    💬 2    📌 0

Congratulations! Nice work.

26.11.2025 06:55 — 👍 0    🔁 0    💬 0    📌 0

Fantastic work. Congratulations!

26.11.2025 06:54 — 👍 1    🔁 0    💬 0    📌 0

Special thanks to @Anusandhan National Research Foundation (ANRF), @Department of Biotechnology (DBT) Govt. of India, @Indian Institute of Science Bangalore, and
@embo.org for the support.

24.11.2025 05:55 — 👍 3    🔁 0    💬 0    📌 0

XCI-ited to share that @Runumi from our lab recently attended the Gordon Research Conference on "Epigenetic Variation: Mechanisms and Impact across Systems" held in Barcelona, Spain. She presented her work on role of #m6A-RNA in #embryogenesis and dosage compensation #X-inactivation.

24.11.2025 05:55 — 👍 1    🔁 0    💬 1    📌 0

Special thanks to @Anusandhan National Research Foundation (ANRF), @Department of Biotechnology (DBT) Govt. of India, @Indian Institute of Science Bangalore, and @embo.org for the support.

21.11.2025 13:00 — 👍 1    🔁 0    💬 0    📌 0

Thrilled to share that @Avinchal from our lab presented her work on effect of heat-humidity stress on fetal development and #epigenetic regulation in the recent #GordonConference on "Epigenetic Variation: Mechanisms and Impact across Systems" #ClimateChange #GlobalWarming #MaternalChildHealth

21.11.2025 13:00 — 👍 1    🔁 2    💬 1    📌 0

Special thanks to @Anusandhan National Research Foundation (ANRF), @Department of Biotechnology (DBT) Govt. of India, @Indian Institute of Science Bangalore, and @embo.org for the support.

21.11.2025 12:58 — 👍 0    🔁 0    💬 0    📌 0

Interesting study showing how H3K36me2 modulation is critical for post-implantation DNAme re-establishment. #epigenetics #histone #EarlyDevelopment

13.11.2025 05:12 — 👍 3    🔁 1    💬 0    📌 0

Excited to receive the Best Poster Award at the 9th Asian chromatin meeting 2025 in IISER Pune! Huge thanks to my mentor Srimonta for his guidance. Thanks to organizers of #ACM2025 for this wonderful opportunity!
#iiscbangalore #EMBO

07.11.2025 05:43 — 👍 3    🔁 1    💬 1    📌 0

Congratulations!

07.11.2025 05:46 — 👍 1    🔁 0    💬 0    📌 0

Runumi, from our lab, had a fantastic week at the @embo.org Epitranscriptome workshop at EMBL Heidelberg! She presented her work on the role of m6A RNA modification in #embryogenesis #stemcell specification and #Xinactivation. #EMBOEpitrans
Thanks to IISc, ANRF-India, DBT-India, @insdb.bsky.social

07.11.2025 05:38 — 👍 4    🔁 0    💬 0    📌 0