Super excited to share our latest work on RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection!
www.biorxiv.org/content/10.1...
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RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection https://www.biorxiv.org/content/10.1101/2025.07.02.662774v1
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RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection https://www.biorxiv.org/content/10.1101/2025.07.02.662774v1
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A huge thank you to the American Cancer Society @americancancersoc.bsky.social for funding this work in our lab through a Research Scholar award!
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This work was spearheaded by two amazing grad students, co-first authors Vikas Peddu & Alex Hill, with significant contributions from Sreelakshmi Velandi Maroli & Connor Mattingly, as well as our wonderful collaborators Joshua Gardner, Karen Miga, and Rebecca Fitzgerald!
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Our study highlights the utility of our long-read sequencing-based RNA liquid biopsy approach for discovering and targeting early stages of disease with molecular precision.
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Through our LOCATE-seq RNA liquid biopsy platform technology, we also discovered potential therapeutic targets, including metabolic, signaling, and immune checkpoint pathways, that are highly upregulated in both precancer and cancer patients.
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Using these novel, unannotated cell-free RNAs, we built a custom transcriptome reference for quantification, feature selection, and machine learning to accurately classify both precancerous Barrett's esophagus with high-grade dysplasia and early-stage esophageal adenocarcinoma.
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We leveraged the power of single-molecule, long-read sequencing of cell-free RNA using Oxford Nanopore Technologies' PromethION platform @nanoporetech.com to discover over 270,000 novel, intergenic cell-free RNAs.
10.07.2025 18:36 β π 0 π 0 π¬ 1 π 0
Super excited to share our latest work on RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection!
www.biorxiv.org/content/10.1...
10.07.2025 18:34 β π 6 π 4 π¬ 2 π 0
Register today for RNA 2025 - the 30th Annual Meeting of the RNA Society! This yearβs meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27 - June 1.
www2.rnasociety.org
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We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open!
www2.rnasociety.org
This yearβs meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.
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NCI Early K99/R00 Fellow & Damon Runyon Fellow @Harvard Medical School & MGHCancerCenter | Biophysics PhD Paszek Lab @Cornell | Physics BS @KAIST; Glycocalyx, Mucins, Immunoengineering, CAR-T, Biophysics
Website: https://sites.google.com/view/sangwoopark/
Liquid biopsy & transcriptomics for biomarker discovery in cancer and beyond. Robust science, reproducibility & RNA-based diagnostics. π https://flomics.com
PhD Candidate at UofT | Chemist π§ͺ | Developing lipid nanoparticles for RNA delivery in the OFK lab | Co-founder of AzaneTx
RNA Lab studying ribosomes biogenesis and how rRNA and tRNA modifications regulates translational reprogramming in cancer at UTHealth
UCSC Chemical Screening Center Director of Operations. CSC.ucsc.edu
Scientist, Husband, Father, Potter, Athlete, bengal cat lover, Great Dane addict, dungeons and dragons fanatic. Hartford, CT
Professor and Chair, Department of Genetics and Genome Sciences, Associate Director Institute for Systems Genomics, UConn Health
We study how micro-environmental and epigenetic mechanisms drive cancer cells into dormancy. We seek to control this biology to prevent and treat metastasis. https://einsteinmed.edu/faculty/16974/julio-aguirre-ghiso
Co-lead R&D at MGZ Medical Genetics Center Munich β’ Former PhD student/postdoc in @NovoaLab at @CRGenomica β’ she/her
We study RNA Biology using a variety of approaches.
medicine.yale.edu/lab/steitz/
Assistant Professor Dept. Pharmacology. Northwestern University, Chicago. RNA biologist. RNA-modifying enzymes. Protein synthesis.
Postdoc in Bevilacqua Lab @PennState | RNA structure and ribozymes | Ph.D. UC Irvine, BS-MS IISER Bhopal (India)
We are 1 of only 7 NCI-Designated basic research cancer centers in the nation, driving discovery through collaboration and innovation. Our scientists unite cutting-edge technology and multidisciplinary expertise to transform cancer diagnosis and treatment.
Researching molecular basis of neuronal communication and synaptic plasticity | Clem Jones Centre for Ageing Dementia Research | Queensland Brain Institute | The University of Queensland - Australia | NHMRC MIND-AD CRE
www.anggonolab.org
We develop (non-coding) RNA therapeutics for incurable diseases using genomics and bioinformatics. PI: Rory Johnson
The Koch Institute brings interdisciplinary approaches together to advance the fight against cancer.
More places to follow us: http://bit.ly/m/mitkochinstitute
Molecular Biologist (aemonten.github.io) δΈ¨Chief Editor @ CSH Protocols (cshprotocols.cshlp.org) δΈ¨Head of the Integrity in Publishing Group at CSHL Press δΈ¨Chair "Molecular Biosystems Conference" (molbiosystems.com) δΈ¨(Oxford) Comma King δΈ¨Central Dogma Police
Lecturer at UNSW Sydney; Visiting Scientist at Garvan Institute of Medical Research -
Designing embedded systems for bioinformatics applications.
Associate Professor @ UC-Davis | Former Senior Director @ Exai Bio | Computational Biology, ML/AI, Genomics, RNA, Cancer
