Daniel Arango

ZAK activation at the collided ribosome - Nature The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫

www.nature.com/articles/s41...

A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...

Congratulations!

Thank you, Ahmad!

*tough

Excited to share this preprint from my lab. We report a potent and site-specific inhibition of translation initiation by 2’O methylation.

It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology

How Trump Blew Up Northwestern’s Business Model The federal government froze the university’s research funding. It hasn’t offered the school a way to get it back.

New Wall Street Journal about Northwestern and the funding freeze.

[Gift link]

www.wsj.com/us-news/educ...

1/n

👏

👏

@thedailynu.bsky.social Northwestern is still supporting our research despite not receiving any $ from active and new fundable grants. Definitely unsustainable and anxieties are piling up..

Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.

Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.

Worried Northwestern lab directors describe ‘bleak’ atmosphere in wake of Trump research funding freeze The Trump administration’s freezing of $790 million in federal research funding for Northwestern University has left concerned lab directors without key grants and forced the university to spend mi…

I helped explain to the Chicago Tribune the enourmous and irrational damage the NIH funding freeze is causing at Northwestern. “You’re at risk of losing an entire next generation of scientists" "it’s terrifying; it’s completely senseless." www.chicagotribune.com/2025/06/07/w...

Keep in mind: these are AWARDED grants, with Notice of Awards. The federal government is not honoring existing contracts with this university, refusing to reimburse for costs charge on awarded grants.

Professors and researchers at Chicago-area universities said federal funding cuts are leaving research projects unfinished.

Julius Lucks, a chemical engineering professor at Northwestern, speaks on if another sector could fund university research.

to.wttw.com/3Ygl3T8

Ready for the next RNA session in @asbmb.bsky.social meeting. We start soon...

Happened to me too

In the midst of everything it feels particularly appropriate to highlight all the amazing #RNA research taking place at #NIH!

Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!

An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation Cancer cells frequently enhance ribosome production to support rapid growth. Here, Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved element (CRNDEUCE) promotes 60S r...

It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...

Letter from the NIH indicating that my grant has been terminated (though it seems we can keep the remaining funds for this year?)

Finally got the notice. Very sad day for the MOSAIC program that supported some of the most amazing scientists I know, as well as some of the awesome people on my lab.

So proud of this incredible work from @g-agarwal.bsky.social from our group with help from many fantastic folks in our lab and inspiring collaborators, including @kharaslab.bsky.social, Alex Bick, @yashpershad.bsky.social, and many others! Please check out Gaurav's awesome 🧵👇👇

Small proteins can be more complex than they look!

We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!

There are days in life that shake you.

I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵

YouTube video by KING 5 Seattle Potential NIH funding cuts could affect local cancer research

We were delighted to have @king5news.com.web.brid.gy visit us in the Termini Lab to discuss how NIH funding cuts could affect cancer research:

m.youtube.com/watch?v=Szo9...

We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

NIH is the best investment there is.

www.forbes.com/sites/michae...

The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. Read our statement: https://buff.ly/4gRXNB8

The integrated stress response regulates 18S nonfunctional rRNA decay in mammals To maintain translational fidelity, cells degrade decoding-incompetent ribosomes through the 18S nonfunctional rRNA decay (NRD) pathway. Coria et al. demonstrate that the concerted actions of GCN2, RNF10, and RIOK3 lead to a block in translation…

Online Now: The integrated stress response regulates 18S nonfunctional rRNA decay in mammals

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.

Please amplify. If you are also able to host fly strains, add your name as well.

Interested in RNA biology, cancer or vascular research? I have a position open for either a research assistant or a new postdoc to start expanding the fast-growing research area of cardio-oncology! Apply here: jobs.ncl.ac.uk/job/Newcastl...
Happy to have informal chats! Please share 🧬.

We are looking for a postdoc to work on #lncRNAs, #translational regulation and #Cancer. If you are passionate, curious and able to work independently please consider to to e-mail me to discuss this further.