Faye

Physical Activity and Incident Atrial Fibrillation in African Americans: The Jackson Heart Study | Circulation

Our paper on Physical Activity and #Afib @jacksonheartt.bsky.social published! www.ahajournals.org/doi/full/10....

23.07.2025 13:55 — 👍 2    🔁 3    💬 0    📌 0

Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF

Manning & Rivera et al. (www.jacc.org/doi/10.1016/...) show that pruning just a few capillaries in the SA node plunges the heart’s pacemaker into metabolic overdraft—slowing the rate and jacking up beat-to-beat variability. The physiological equivalent of running on fumes. @jaccjournals.bsky.social

23.07.2025 18:06 — 👍 13    🔁 7    💬 1    📌 2

In a European cohort, lifetime risk of developing HFrEF was greater in men, while women were at greater risk of developing HFpEF.
8 modifiable RFs substantially accounted for developing HF.

#CardioSky
academic.oup.com/eurheartj/ad...
@anastasiasmihaili.bsky.social @vietheartpa.bsky.social

05.02.2025 13:30 — 👍 10    🔁 8    💬 0    📌 0

Delighted w our Cunsensus Document on preventing heart failure in cardiac-oncology at #EJHF @escardio.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

Potential importance of SGLTi noted academic.oup.com/eurjpc/advan...

With great colleagues who R not on Blue Sky-repost to attract them here!

19.07.2025 18:00 — 👍 5    🔁 4    💬 2    📌 0

Sodium-Glucose Cotransporter-2 Inhibitor in Patients With Heart Failure and Mildly Reduced or Preserved Ejection Fraction This cohort study evaluated adoption rates of sodium-glucose cotransporter-2 inhibitors at US hospitals for patients with heart failure and mildly reduced or preserved left ventribular ejection fracti...

SGLT2i use for HFpEF and HFmrEF approaching 1 in 4 after hospitalization (as of Sept '23) Favorable health economics at current net prices. Even better next year with multisource dapa. #cardiosky #AHA24 #flozins
jamanetwork.com/journals/jam...

18.11.2024 21:03 — 👍 2    🔁 2    💬 0    📌 0

A 🆕 ACC Scientific Statement addresses the management of obesity in adults with #HeartFailure, with a specific focus on those with stage 2 HF with #HFpEF.

Read more: bit.ly/43YJ7vv

#JACC @jaccjournals.bsky.social #CardioSky #MedSky

13.06.2025 16:08 — 👍 4    🔁 4    💬 0    📌 0

Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets | Nature Reviews Cardiology The number of patients with heart failure is expected to rise sharply owing to ageing populations, poor dietary habits, unhealthy lifestyles and improved survival rates from conditions such as hypertension and myocardial infarction. Heart failure is classified into two main types: heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). These forms fundamentally differ, especially in how metabolism is regulated, but they also have shared features such as mitochondrial dysfunction. HFrEF is typically driven by neuroendocrine activation and mechanical strain, which demands a higher ATP production to sustain cardiac contraction. However, the primary energy source in a healthy heart (fatty acid β-oxidation) is often suppressed in HFrEF. Although glucose uptake increases in HFrEF, mitochondrial dysfunction disrupts glucose oxidation, and glycolysis and ketone oxidation only partially compensate for this imbalance. Conversely, HFpEF, pa

Rising heart failure cases (HFrEF, HFpEF) highlight key metabolic differences & similarities. Lifestyle changes & new targets matter! PMID:40544173, Nat Rev Cardiol 2025, @NatRevCardiol https://doi.org/10.1038/s41569-025-01166-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

27.06.2025 06:10 — 👍 3    🔁 1    💬 0    📌 0

Re”FINE”ing the role of non steroidal MRAs in Cardio Kidney Metabolic syndrome — NephJC This week, we will discuss non-steroidal mineralocorticoid antagonist in the multiverse of cardiovascular-kidney-metabolic. What FINEHEART pooled analysis would add to what we already learned from FID...

Finerenone gets the HFpEF nod from FDA - as expected

NephJC coverage of FINEHEARTS www.nephjc.com/news/fineheart

Our editorial on kidney outcomes from FINEARTS: pubmed.ncbi.nlm.nih.gov/39814475/

14.07.2025 18:40 — 👍 15    🔁 5    💬 1    📌 0

What services are currently provided to people with Heart Failure with preserved Ejection Fraction in the UK and what are their components? A systematic scoping review AbstractAim. To review the clinical services currently provided to people with heart failure with preserved ejection fraction (HFpEF) living in the United

New paper alert for anyone interested in HFpEF, check it out here: academic.oup.com/eurjcn/advan...

Important findings on HFpEF in the UK, services are trying, but they recommend change and question the status quo

17.07.2025 15:27 — 👍 2    🔁 0    💬 0    📌 0