Liverpool Centre for Cardiovascular Science (LCCS)

Circulating transthyretin with atrial morpho-functional phenotypes and atrial fibrillation risk, and the modifying role of BMI - BMC Medicine Background Low circulating transthyretin (TTR) concentration has been suggested as a biomarker of transthyretin tetramer instability, a prerequisite for the development of transthyretin cardiac amyloi...

Circulating transthyretin with atrial morpho-functional phenotypes and atrial fibrillation risk, and the modifying role of BMI - BMC Medicine | Background Low circulating transthyretin (TTR) concentration has been suggested as a bioma... | link.springer.com/article/10.1...

Spinal cord stimulation for the treatment of painful diabetic neuropathy and risk of major adverse cardiovascular events, mortality, amputation, infection and suicide: a retrospective cohort study Our results suggest that SCS treatment of PDN is associated with a reduced risk of MACE, all-cause mortality, major amputation, suicide, and staphylococcus aureus infection. The findings provide evide...

Spinal cord stimulation for the treatment of painful diabetic neuropathy and risk of major adverse cardiovascular events, mortality, amputation, infection and suicide: a retrospective cohort study - eClinicalMedicine www.thelancet.com/journals/ecl...

Exercise-based Cardiac Rehabilitation for Coronary Heart disease – the CaReMATCH individual participant data meta-analysis AbstractAims. The effectiveness of exercise-based cardiac rehabilitation (ExCR) for coronary heart disease (CHD) has been debated during the past decade. T

Exercise-based Cardiac Rehabilitation for Coronary Heart disease – the CaReMATCH individual participant data meta-analysis @livuniresearch.bsky.social @livhp.bsky.social url: academic.oup.com/eurjpc/artic...

Cardio-kidney-metabolic complexity in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF registry phase III #Afib @livuniresearch.bsky.social @livhp.bsky.social link.springer.com/article/10.1...

Smog, hałas i światło pod lupą. UMB rozpoczyna międzynarodowy projekt badawczy [WIDEO] Naukowcy z Uniwersytetu Medycznego w Białymstoku wraz z ekspertami z całego świata rozpoczęli międzynarodowy projekt, którego celem jest zbadanie wpływu...

Smog, hałas i światło pod lupą. UMB rozpoczyna międzynarodowy projekt badawczy [WIDEO] | Naukowcy z Uniwersytetu Medycznego w Białymstoku wraz z ekspertami z całego świata rozpoc... | bialystok.tvp.pl/89378907/smo...

Phenotype-guided risk stratification in anticoagulated atrial fibrillation patients: Cluster analysis of the Murcia AF Project III (MAFP-III) #Afib @livuniresearch.bsky.social @livhp.bsky.social www.sciencedirect.com/science/arti...

The integrated multiple event representation framework (IMERF): a case study on critically-ill patients | This study introduces the Integrated Multiple Event Representation Framework (IMERF), a novel methodological approach for... | www.sciencedirect.com/science/arti...

The Prognostic Value of High-Sensitivity CRP in the East Asian Population | JACC: Asia @livuniresearch.bsky.social @livhp.bsky.social www.jacc.org/doi/10.1016/...

Uniwersytet Medyczny w Białymstoku. Aktualności. | Oficjalny serwis Uniwersytetu Medycznego w Białymstoku. | #collaboration @livuniresearch.bsky.social @livhp.bsky.social www.umb.edu.pl/aktualnosci/...

Relationship between sarcopenia and type 2 diabetes mellitus among adults with prediabetes: evidence from a prospective cohort study - Diabetology & Metabolic Syndrome Background The relationship between sarcopenia and type 2 diabetes mellitus (T2DM) among those with prediabetes is largely inconclusive given the heterogeneous findings of previous studies. We aimed to clarify the association between sarcopenia and prediabetes progression to T2DM in adult participants. Methods Participants with baseline prediabetes from the UK Biobank cohort were included in this study. Sarcopenia was classified as present or absent based on the criteria from the 2019 European Working Group of Sarcopenia in Older People (EWGSOP2 criteria) including handgrip strength, muscle mass and walking pace. The primary outcome was incident T2DM during follow-up. Multivariable Cox regression model adjusting for sociodemographic factors, lifestyles, comorbidities, and laboratory measures, was used to assess the association between sarcopenia and risk of T2DM. Results We included 60,325 participants (mean age: 59.6 years, 54.5% females) with baseline prediabetes for analysis, among whom 9,305 (15.4%) had incident T2DM during a mean follow up of 11.4 years. There were 7,139 (11.8%) participants categorized as having sarcopenia. Those with sarcopenia had a higher cumulative incidence of T2DM than those without (19.3% vs. 14.9%, P < 0.001). Sarcopenia was associated with a 22% increased risk of T2DM when compared with no sarcopenia (hazard ratio [HR] = 1.22, 95% confidence interval [CI]: 1.15–1.30) in the fully adjusted model. This association was more evident in participants with a waist to hip ratio < 0.9 (P-value for interaction < 0.05). Conclusions Sarcopenia was associated with increased risk of T2DM in adults with prediabetes. Sarcopenia appears to be a marker for risk of T2DM in people with prediabetes and interventions targeted at preserving and improving muscle health might be another novel potential approach to effectively decelerating prediabetes progression to T2DM.

Relationship between sarcopenia and type 2 #diabetes mellitus among adults with prediabetes: evidence from a prospective cohort study @livuniresearch.bsky.social @livhp.bsky.social dmsjournal.biomedcentral.com/articles/10....

The European Society of Cardiology Council on Stroke: building the future of the multidisciplinary study of stroke The European Society of Cardiology (ESC) Council on Stroke (CoS) is a multidisciplinary body for cooperation, education, and research on primary and second

European Society of Cardiology Council on Stroke: building the future of the multidisciplinary study of #stroke url: academic.oup.com/eurheartj/ar... #collaboration @escardio.bsky.social @livuniresearch.bsky.social @livhp.bsky.social

Understanding structured medication reviews delivered by clinical pharmacists in primary care in England: a national cross-sectional survey @livuniresearch.bsky.social @livhp.bsky.social bmjopen.bmj.com/content/15/9...

Cardiovascular-kidney-metabolic domains and impact on antithrombotic treatment, integrated care and clinical outcomes in patients with atrial fibrillation: results from a prospective European registry Cardiovascular, kidney, and metabolic (CKM) conditions frequently coexist with atrial fibrillation (AF), but their impact in AF population remains poo…

Cardiovascular-kidney-metabolic domains and impact on antithrombotic treatment, integrated care and clinical outcomes in patients with atrial fibrillation: results from a prospective European registry #Afib @livhp.bsky.social @livuniresearch.bsky.social www.sciencedirect.com/science/arti...

Trimetazidine Is Associated With Ameliorated Stroke Risk in Patients With Both Ischemic Heart Disease and Atrial Fibrillation www.ahajournals.org/doi/10.1161/... @livhp.bsky.social @livuniresearch.bsky.social #Afib

LJMU plays key role in fight against heart disease | Liverpool John Moores University
www.ljmu.ac.uk/about-us/new...

❤️ Today is #WorldHeartDay

#LivUni's Centre for Cardiovascular Science is dedicated to advancing the understanding and treatment of cardiovascular diseases through cutting-edge research.

Discover how they are addressing the biggest challenges in heart health

👉 www.liverpool.ac.uk/liverpool-ce...

Relation of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio to residual risk in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF Project III cohort - Cardiovascular Diabetology Background Atrial fibrillation (AF) confers a high risk of thromboembolism and cardiovascular events, which persists despite optimal oral anticoagulation (OAC). The non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio (NHHR) integrates pro- and anti-atherogenic lipid fractions and has been linked to adverse outcomes in high-risk patient populations. The prognostic value of NHHR in anticoagulated AF patients is uncertain. We aimed to evaluate NHHR as a marker of residual thromboembolic and cardiovascular risk in this population. Methods Consecutive AF outpatients initiating OAC between January 2016 and November 2021 were enrolled in this prospective cohort study. NHHR was calculated from baseline non-HDL-C and HDL-C levels, and patients were stratified into two groups. Primary outcomes were thromboembolic events (i.e., composite of ischaemic stroke (IS), transient ischaemic attack (TIA), or systemic embolism) and major adverse cardiovascular events (MACE), comprising myocardial infarction, IS, TIA, or cardiovascular death. Secondary outcomes included cardiovascular and all-cause death. Restricted cubic spline (RCS) models assessed non-linear associations, and multivariable Cox models evaluated associations between NHHR and outcomes. Results 1694 patients (52.8% female; age 76 years [IQR 69–82]; follow-up 1.86 years [SD 0.4]) were included. During follow-up, 97 (5.7%) experienced a thromboembolic event and 126 (7.4%) experienced MACE. RCS analysis showed significant linear associations between continuous NHHR and primary outcomes (p-overall < 0.001). High NHHR was independently associated with increased risk of thromboembolic events (adjusted Hazard Ratio [aHR] 2.15; 95% CI 1.41–3.29; p < 0.001) and MACE (aHR 1.69; 95% CI 1.15–2.48; p = 0.007), compared to the low NHHR group. No significant associations were observed for secondary outcomes. Conclusions In anticoagulated AF patients, high NHHR was independently associated with increased residual thromboembolic and cardiovascular risk. NHHR may improve cardiovascular risk stratification in patients with AF, although external validation in more ethnically diverse cohorts is warranted. Graphical abstract

Relation of the non-HDL cholesterol to HDL cholesterol ratio to residual risk in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF Project III cohort cardiab.biomedcentral.com/articles/10....

Short-term exposure to air pollution and risk of ischemic stroke requiring intravenous thrombolysis: a population-level analysis in Poland from the EP-PARTICLES study | Environmental Health | Full Text ehjournal.biomedcentral.com/articles/10....

School of Engineering marking World Heart Day @liverpoolccs.bsky.social

Association between rivaroxaban and the prognosis of patients with acute myocardial infarction and new-onset atrial fibrillation AbstractBackground. New-onset atrial fibrillation (AF) in the setting of acute myocardial infarction (AMI) is associated with higher risks of stroke and mo

Association between rivaroxaban and the prognosis of patients with acute myocardial infarction and new-onset atrial fibrillation url: academic.oup.com/pmj/article-... #Afib @livhp.bsky.social

Direct oral anticoagulants in very elderly and high bleeding risk patients with atrial fibrillation often excluded from oral anticoagulation therapy: a nationwide population-based cohort study AbstractBackground and Aims. In the Edoxaban Low-Dose for Elder Care Atrial Fibrillation Patients (ELDERCARE-AF) trial, very low-dose edoxaban (15 mg once

Direct oral anticoagulants in very elderly and high bleeding risk patients with atrial fibrillation often excluded from oral anticoagulation therapy: a nationwide population-based cohort study url: academic.oup.com/europace/art... #Afib @livhp.bsky.social

#teamLCCS is all about #collaboration #nosilos #nobunkers

@livhp.bsky.social @target-horizoneu.bsky.social

At @liverpoolccs.bsky.social World Heart Day workshop. Keynote by Dr Kuzma (Poland) on role of environment in CVD and stroke. We did an overview of aorta research in Liverpool @jmadine.bsky.social #worldheartday #liverpool

A man smiles for a picture taken in a harbour he wears black famed glasses. Text overlaid reads: “These results are significant because fear of fertility side effects specifically attributed to valproate can lead men to discontinue the medication, risking uncontrolled seizures, mental health deterioration, hospitalisation, or death in extreme cases.” Dr Gashirai Mbizvo, Deputy Director for Epilepsy Research, Liverpool Interdisciplinary Neuroscience Centre.

NEWS | A large-scale international study led by the University of Liverpool and funded by @epilepsyinst.bsky.social has found little evidence that sodium valproate significantly impairs male fertility in men with epilepsy or bipolar disorder.

Read more ⬇️

news.liverpool.ac.uk/2025/09/15/s...

ffect of digital messaging on blood pressure control in general practice: observations from the BP@Home programme in wirral area | Journal of Human Hypertension nature.com/articles/s41...
@livhp.bsky.social #hypertension

Accelerometer-Measured Physical Activity Timing and Risk of Incident Atrial Fibrillation: A UK Biobank Cohort Study AbstractIntroduction. Although moderate-to-vigorous physical activity (MVPA) is linked to a lower risk of atrial fibrillation (AF), the influence of its ti

Accelerometer-Measured Physical Activity Timing and Risk of Incident Atrial Fibrillation: A UK Biobank Cohort Study url: academic.oup.com/eurjpc/artic... #Afib @livhp.bsky.social

Dynamic Increase of the C2HEST Score in Relation to the Development of Incident Atrial Fibrillation: A Longitudinal Cohort Study | Journal of the American Heart Association

Dynamic Increase of the C2HEST Score in Relation to the Development of Incident Atrial Fibrillation: A Longitudinal Cohort Study | Journal of the American Heart Association www.ahajournals.org/doi/10.1161/...

Clinical Complexity in Patients with Atrial Fibrillation: Exploring Differential Risk Profiles from European and Asian Cohorts url: academic.oup.com/europace/art... #Afib @livhp.bsky.social

<em>Diabetic Medicine</em> | Diabetes UK Journal | Wiley Online Library Aims Diabetes is characterized by clinical heterogeneity. This study aimed to identify different clinical phenotypes of real-world people with diabetes and to assess their associations with major ad...

Clinical risk phenotypes in #diabetes and their associations with adverse cardiovascular events: A report from the Silesia Diabetes‐Heart Project - Mantovani - Diabetic Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Joint trajectories of skeletal muscle and fat mass in relation to glucose homeostasis: 6‐Year findings from adults aged ≥50 years y dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...