Babraham Institute

FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling, uncovering a vuln...

www.embopress.org/doi/full/10....
Congratulations to Suzan Ber and @aesposito1975.bsky.social on their lovely study of KRAS alleles on glutamine and nitrogen metablism and signalling - just out in EMBO Reports. Such a pleasure to collaborate on this fascinating project! 👏

RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...

I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...

🚨UK Ageing Research League Table update

@babrahaminst.bsky.social claims 1st 🥇
@unibirmingham.bsky.social in 2nd 🥈
@ox.ac.uk in 3rd 🥉

@ucl.ac.uk & (bluesky shy?) Univeristy of Westmisnter narroly miss the podium & are tied for 4th.

How did your institution rank?

bsra.org.uk/uk-ageing-re...

Frontiers in Stem Cell Innovation 2026 Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery

The countdown is on! One week left for early birds to get their tickets to the Frontiers in Stem Cell Innovation conference 🎟️

📅 5–6 February 2026
📍 Cambridge, UK
Hosted by The Babraham Institute and Newcastle University.

Register now www.eventbrite.co.uk/e/frontiers-...

Labelled black and white thumbnails of four video clips with titles: Cage cleaning, daily visual checks to ensure mouse welfare, Enrichment provision, Health checking our mice.

Or watch one of our videos covering daily visual checks, cage cleaning, health checks, and enrichment provision: www.babraham.ac.uk/our-research...

Text reads: Take a 360 degree tour of our animal facility. Step 1: Visit. Step 2: Pick your route/area of interest. Step 3: Explore!

If you’re interested in seeing how we care for the mice, you can take a virtual tour of our animal facility: www.babraham.ac.uk/our-research...

The graph title is: 2020-2024 Animal Use Statistics: Procedures & Severity The graphic shows a horizontal bar chart showing the breakdown of severity numbers for each year from 2020 to 2024. In 2024, a total of 30,389 procedures were carried out, with 23,257 being sub-threshold, 6,581 being mild, 516 being moderate and 35 being severe. For previous years the data is as follows: In 2023, a total of 33,364 procedures were carried out, with 25,585 being sub-threshold, 7,349 being mild, 375 being moderate and 55 being severe. In 2022, a total of 39,157 procedures were carried out, with 4,069 being sub-threshold, 34,651 being mild, 389 being moderate and 48 being severe. In 2021, a total of 40,750 procedures were carried out, with 4,008 being sub-threshold, 36,093 being mild, 514 being moderate and 135 being severe. In 2020, a total of 48,599 procedures were carried out, with 7,613 being sub-threshold, 40,223 being mild, 664 being moderate and 99 being severe.

It’s #AnimalStats day in the UK today. You can see our animal stats at any time on our website, as well as finding out how and why we use mice in our research.
www.babraham.ac.uk/our-research...

Check out the line up of amazing speakers at the 2026 GRC Autophagy meeting in Ventura, California, 15-20 March. Register now and share your latest findings.
www.grc.org/autophagy-in...

Text reads: Frontiers in stem cell innovations, 5 & 6 February 2026 Wellcome Genome Campus and Babraham Research Campus, Cambridge, UK Partnered with the Annual World Organoid and Organ-on-a-chip Research Day+ (WORD+) Speakers Lyle Armstrong - Newcastle University, Bilada Bilican - AstraZeneca, Adriana Buskin - Newcastle University, Maria Christophorou - Babraham Institute, Davide Danovi - Migration Biotherapeutics, Fiona Ducotterd - Alzheimers Research UK & UCL, Mark Kotter - Cambridge Stem Cell Institute & bit.bio, Nick Ktistakis - Babraham Institute, Marzena Kurzawa-Akanbi - Newcastle University, Majlinda Lako - Newcastle University, Rick Livesey - Talisman Therapeutics & UCL, Matteo Martufi - GSK, Fiona Menzies - Eli Lilly & Co, Peter Rugg-Gunn - Babraham Institute, Stefan Schoenfelder - Babraham Institute,

Interested in #StemCell research and technologies? Then hopefully this pairing of events is already marked in your calendar for February 2026. If not, take a longer look!
www.eventbrite.co.uk/e/frontiers-...

Postdoctoral Researcher (Howard Group) | John Innes Centre An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.

VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system.

www.jic.ac.uk/vacancies/po...

Closing date - 9 November 2025
Salary - £37,500 - £45,350
Contract - 36 months, full-time

ICYM our announcement from last week: Two incredible events unite to make one unmissable opportunity!
www.eventbrite.co.uk/e/frontiers-...

NEW PUBLICATION | A research collaboration between the Rugg-Gunn lab and Lonza is moving researchers towards the ability to drive transgene expression (in CHO cells) at higher levels to improve biopharmaceuticals yields.

analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10....

🚀 Applications are open for the Bio-spark Entrepreneurial Programme!

Are you an early career researcher hoping to consider options outside the academic world? Are you looking for advice, experience or mentorship?

🗓️ Apply by 13 Oct
🔗 www.gravity.cam.ac.u...

Frontiers in Stem Cell Innovation 2026 Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery

3 days - 2 events - 1 amazing opportunity!
Get set for two events showcasing bioscience innovation.
4-5 Feb - WORD+ 2026 event
5-6 Feb - our Frontiers in Stem Cell Innovation (FISCI) conference
📍Cambridge
Registration for FISCI is open now: www.eventbrite.co.uk/e/frontiers-...

Text reads: News - Prizes for team behind game-changing multi-omics method to decode gene regulation. Image shows Dr Yang Wang (left) and Dr Peter Rugg-Gunn (right) shown over a data analysis plot from the scMTR-seq technique.

NEWS | A new multi-omics method enabling the profiling of multiple histone modifications and gene expression in single cells, and the researchers behind it, have been recognised with two awards. Congrats to the Rugg-Gunn lab and everyone involved!

www.babraham.ac.uk/news/2025/09...

#epigenetics

YouTube video by Dementia Researcher Advise on Publishing Your Research

Publishing Your Research? Resource for early career researchers from Alzheimer's Society Retreat

Dr Johanna Jackson @imperialcollegeldn.bsky.social
Dr Simon Andrews @babrahaminst.bsky.social
Dr Christian Schnell @plosbiology.org
Cherie Nyota @alzheimerssoc.bsky.social

youtu.be/ACqKndCoM3Q?...

We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social

🔥 now including in vivo 🐭&👤 embryo data

www.biorxiv.org/content/10.1...

Save-the-date information: New approaches to Early embryogenesis & epigenetics February 16 - 18 2026 Max Planck Institute for Molecular Genetics, Berlin, Germany

2nd Meeting on Early Embryogenesis and Epigenetics
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026

Great to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social

🔬We have a fully funded Cambridge Biosciences DTP PhD postion to study #Proteostasis and #Aging in colloboration with @jrkumita.bsky.social @Pharmacology. Details on the project ▶️https://tinyurl.com/2zhkjjhs + bbsrcdtp.lifesci.cam.ac.uk/how-apply . Please RT.

a man with a mustache wearing a black hat and a blue shirt ALT: a man with a mustache wearing a black hat and a blue shirt

This #TrainingTuesday why not check out our recently scheduled dates for the autumn term
#Bioinformatics #ComputationalBiology #ECRchat
www.bioinformatics.babraham.ac.uk/cgi-bin/publ...
@babrahaminst.bsky.social

NEW EPISODE: Reflections from last weeks International Research Culture Conference #IRCC25 at University of Warwick organised by the National Centre for Research Culture featuring guests Chandrika Nair, Alys Kay, and Dolly Coates. Find it in your podcast app or here buff.ly/tBStCUO

This shows an antibody heavy chain successfully pairing with a surrogate light chain and signalling B cell progression. In contrast a non-pairing heavy chain fails to signal, the B cell stalls, and the suboptimal V gene is replaced by an upstream V to make a pairing heavy chain and rescue the B cell.

Delighted to share that our paper solving the age-old mystery of whether and how VH-replacement shapes the antibody repertoire is in @embojournal.org
www.embopress.org/doi/full/10....
Fantastic work from Harry White, @peterch405.bsky.social @babraham-bioinf.bsky.social @babrahaminst.bsky.social

NEWS | Work just published by the Corcoran lab has described a mechanism estimated to be responsible for shaping the generation of up to half of all antibodies.

www.babraham.ac.uk/news/2025/09/institute-immunologists-new-process-antibody-diversity

@annecorcoran.bsky.social

Exciting news📣: #ProteostasisUK is hiring a network manager to help drive an ambitious, #BBSRC funded initiative connecting and expanding #Proteostasis research across the UK. Position initially for 3 years. Deadline September 28th. More info: tinyurl.com/f83rp673 & proteostasisuk.co.uk Please RT

Will you be at the @bsrageing.bsky.social ‪#BSRA2025 this week? Look out for Institute contributions:
- @martint-babraham.bsky.social: RNA binding proteins in Tregs (Friday)
- Rahul Samant: proteostasis strategies, stress resilience & senescence (Friday)
- Institute facilities showcase

Delighted to welcome Dinis Calado to Babraham. A fantastic appointment and a lovely guy! Welcome DC!

Text reads: News: Institute welcomes Dr Dinis Calado as a senior group leader in the Immunology programme. Main image (left) shows Dinis Calado. Two images on the right are 3D confocal images of mouse bone marrow showing plasma cells (antibody producing cells; in red), endomucin⁺ vasculature (green), immunoglobulin (white), and cell nuclei stained with DAPI (blue). Credit: Abdouramane Camara, Immunity & Cancer Laboratory, The Francis Crick Institute.

NEWS | We're delighted to welcome @diniscalado.bsky.social to the Institute as a senior group leader in our #immunology programme!

The Calado lab works at the interface of immunity, #cancer, and #ageing. Learn more: www.babraham.ac.uk/news/2025/09...

How discovery research and collaboration between the @mrclmb.bsky.social, University of Cambridge, Babraham Institute, and clinicians from Addenbrooke’s identified the mutation that causes a rare immune disorder (APDS) and led to a pioneering treatment giving patients "a new lease of life".

📣 Milner Seminars: Focus on spatial biology

Please join us on 25 September for the next instalment of our seminar series, with talks from Esther Baena (Owkin) and Mats Nilsson (@stockholm-uni.bsky.social and @sangerinstitute.bsky.social).

Find out more and register: ow.ly/myoT50Wu1AX