Seth Thomas Scanlon

Check it out! New content each week!!!

@science.org is looking for a new research editor to handle papers in the field of next-generation #medicine! Spread the word!!!

bit.ly/4bWOJfn

The January 2026 issue of #Science #Immunology is out now!

Thanks to Rioka Hayama for another fantastic cover!!!

Happy 2026!!!

#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!

bit.ly/SciImm_free

#ScienceImmuno10gy

#Science #Immunology will be sponsoring a prize for the best poster presentation! The abstract deadline is fast approaching though, so don't delay!

I hope to see many of you in marvelous Ghent this coming March!

The latest issue of #Science #Immunology is out now! This week:

• evaluating large language models ( #LLMs ) / #AI as potential #systems #vaccinology tools

• de novo #thymus #regeneration in the #axolotl!

New content every week!!!

Public access is not equal access On 25 August, the White House Office of Science and Technology Policy provided guidance for scientific publishing aimed at making publications and their supporting data—the products of federally funde...

The other five journals in the Science family are all Green OA, which means authors can place the accepted version of their manuscript in a personal website &/or repository of their choice immediately upon publication. A 2022 Science editorial discusses the rationale for this policy:

Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity.

This week in #Science #Immunology, Lambrecht & Hammad labs (@viblifesciences.bsky.social) use #Danish Nat'l Patient & Prescription Registries + mouse models to show that maternal #allergy & neonatal #RSV infection synergize via FcR-mediated allergen uptake to drive development of early life #asthma!

ONLINE COVERB Cell Help Measures Up Against Parasites. How B cells acquire antigens from large pathogens, including single-celled parasites, to support T cell–driven humoral responses is not well understood. Gao et al. used Ighg2A10 B cells specific for the surface Plasmodium falciparum circumsporozoite protein (PfCSP) to examine the interaction between B cells and Plasmodium berghei sporozoites engineered to express PfCSP. Ighg2A10 B cells could internalize and present cognate and bystander surface antigens, which resulted in both intramolecular and intermolecular CD4 T cell help. This help either suppressed or supported protective B cell responses depending on whether the CD4 T cells recognized cytosolic or surface sporozoite antigens. This month’s cover is a pseudocolored and digitally altered scanning electron microscopy (SEM) micrograph of Plasmodium sporozoites (pale purple) attached to Ighg2A10 B cells (bright pink) at one end. Martin Oeggerli (Micronaut) 2025, with Xin Gao and Ian Cockburn, The John Curtin School of Medicine Research, Australian National University

Nov issue of #Science #Immunology out now!

This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites!

scim.ag/4qQA6Q6

Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells.

Now in #Science #Immunology: Hirahara lab reports activated #TH2 cells store LC-UFAs present in inflamed #lung within #lipid droplets. Subsequent catabolism via #microlipophagy induces ST2-hi effector & memory TH2 cell phenotypes, exacerbating #type2 #airway #inflammation!
#asthma #immunometabolism

Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes Protein palmitoylation and sphingolipid metabolism control lytic granule release in cytotoxic lymphocytes via membrane targeting of SNAP23.

Recently in #Science #Immunology: Kalinichenko, Huemer, @boztugk.bsky.social, & colleagues report than #sphingolipid #metabolism & protein #palmitoylation play critical roles in the killing of target cells by #cytotoxic #lymphocytes!

Last week in #Science #Immunology: two papers from Bill Schief, Facundo Batista, @profshanecrotty.bsky.social, & al. provide evidence that simultaneous #immunization with multiple #bnAb #immunogens could be a viable #HIV #vaccine strategy!

Xie & al.
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Sutton & al.
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Main stage of the Aula Medica auditorium in Stockholm, Sweden. Three people are standing near the lectern on stage. Text on the screen above the stage reads "50th annual meeting of the Scandinavian Society for Immunology" and features the SSI logo.

I'm so excited to be in stunning Stockholm for the 50th annual meeting of the #Scandinavian Society for #Immunology!

swimm.se/ssi-2025/

@finnsocimm.bsky.social @swimm-immuno.bsky.social @yssi-immunology.bsky.social @ki.se

To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025!

bit.ly/SciImm_free

Thanks, @natrevimmunol.nature.com, for highlighting this exciting recent paper in #Science #Immunology!

This week in #Science #Immunology! 👇

Decoding the Brain Tumor Immune Microenvironment. Brain tumors originate either from within the brain or as metastases from other tissues and pose major clinical challenges because of their heterogenous and aggressive nature. Bunse et al. review the cellular and molecular determinants of brain tumor antigenicity and factors that contribute to the immunosuppressive brain tumor microenvironment (TME). This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) TMEs as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain. Credit: Rioka Hayama

The October issue of #Science #Immunology is out now! This week: how #TCR avidity shapes #CD8 #TCell responses to #mRNA #vaccines and the latest research on the immunology of #brain #tumors reviewed! New content added every week!

scim.ag/46TGooP

Design of a potent interleukin-21 mimic for cancer immunotherapy A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

David Baker & colleagues develop an #IL21 mimic (21h10) that is more stable & shows x-reactivity against both human & murine #IL21R. 21h10 promotes potent antitumor responses in mice and in human #melanoma tumor explants, expanding low-affinity CD8 #TCells & #TH1 cells & reducing #Tregs in #tumors!

Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system ILC2-neuron cross-talk contributes to the maintenance of nerve structure and function of the peripheral nervous system.

Now in #Science #Immunology: Deshpande, Klose, & al at Charité—Universitätsmedizin Berlin report that #ILC2 resident in #PNS communicate with neurons via #IL13 to maintain #nerve structure & pain thresholds. Mice lacking ILC2 or whose neurons are Il4ra-KO exhibit #hypersensitivity & #gait defects!

Inhibitory immune checkpoints in cancer immunotherapy Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!

Nuclear polarization to the immune synapse facilitates an early transcriptional burst Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!

Shining a Light on Naïve T Cell Homeostasis: Homeostatic maintenance of naïve T cells is critical to maintain a large and diverse T cell pool. However, the underlying mechanisms regulating this process are not well understood. Wu et al. report that the RNA helicase DDX55 regulates the homeostatic maintenance of naïve T cells by preventing MYC from binding to enhancer- and promoter-like transposable elements (TEs) near T cell activation genes. In naïve T cells, DDX55 prevents the inappropriate activation of TEs and ensures their genomic stability by preventing R-loop formation. This month’s cover features a light bulb with its filament stylized as a DNA double helix. Its left half glows with an intact filament, symbolizing TEs as regulators, and its right side is dimmed and features a broken filament, representing TEs’ disruptive potential. Credit: Bingyu Yang and Jianling Zhu/Sichuan University

The September issue of #Science #Immunology is out! This week: METTL1 m⁷G RNA modification of NAD+ #metabolism → #macrophage -mediated #inflammation; proenkaphalin+ #Tregs restrain skin inflamm via control of #nociception; #RNA helicase DDX55 is regulator of naïve #TCell homeostasis

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Way to go, @cnfogg.bsky.social!

Heads up: @science.org is looking for a new research #editor based in the US or UK to handle papers in #InfectiousDiseases (e.g., #virology, #microbiology, #parasitology) & #microbiome research! This is an amazing opportunity, so don't delay! Applications are due 22 SEP!

Home - IUIS 2025 IUIS 2025 ACCREDITED WITH 26 CME CREDITSThe 19th International Congress of Immunology (IUIS 2025), Vienna, Austria 17/08/2025 – 22/08/2025, has been accredited by the European Accreditation Council fo...

Heads up: @science.org 's immunology editor @sarahhross.bsky.social and I will both be attending the @iuis-online.bsky.social 19th International Congress next week in the ever enchanting city of #Vienna! We hope to see many of you there!

The cover was illustrated by Rioka Hayama, who also designed #Science #Immunology 's wicked JAN 2025 cover!

riokahayama.com

COVER This illustration depicts the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. The infant silhouette contains DNA, and the figures are enveloped by the nuclear and plasma membranes. These components reference the evolution of immunity over millennia, as viruses integrated into the genome and as life progressed from single-celled to multicellular organisms. See the special section beginning on page 586. Illustration: Rioka Hayama

This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover!

scim.ag/3UqRrA6

The cover depicts an hourglass with beneficial (blue) & pathogenic (orange) microbiota drawn as sand. Transferred Tregs lining the hourglass cause the “sand” to flow in reverse, highlighting their ability to undo some of the effects of inflammaging by restoring gut barrier integrity!

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

This week's cover, illustrated by the amazing Ashley Mastin, highlights work by @mmgomezheras.bsky.social & al.!