Johannes Herpell

Great to see this really cool story (see quoted post) published in @newphyt.bsky.social!

nph.onlinelibrary.wiley.com/doi/full/10....

Congratulations @laravdijck.bsky.social, @parkergroup.bsky.social!

Plant-Scopoletin-Fungal Endophyte-Iron

#PlantScience #Coumarin #PlantImmunity #PlantNutrition

How can we better understand the plant immune system? In my new @cp-cellhostmicrobe.bsky.social piece, I propose “immune cell states” as a framework for uniting molecular and cellular perspectives.

www.cell.com/cell-host-mi...

Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology The extracellular space (apoplast) in plants is a key battleground during microbial infections. To avoid recognition, the bacterial model phytopathogen Pseudomonas syringae pv. tomato DC3000 produces ...

Fascinating innate immune evasion strategy in SCIENCE #glycotime

𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘴𝘺𝘳𝘪𝘯𝘨𝘢𝘦 makes GLYCOSIRIN, a novel iminosugar that blocks plant glycosidases from degrading bacterial flagellin—hiding pathogens from plant immune sensors. New cryo-EM insights reveal exactly how this stealthy trick works

Low overlap of transcription factor DNA binding and regulatory targets - Nature A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between their binding sites on DNA and regulation of nearby genes.

Nature research paper: Low overlap of transcription factor DNA binding and regulatory targets

https://go.nature.com/4jedGUz

Would you like to study metabolite-based microbe-microbe or plant-microbe interactions but do not have the tools to?
@chesneau-g.bsky.social came up with a simple solution with great potential! Check out our new publication in @naturecomms.bsky.social and Guillaume’s 🧵 below for details👇

MetaFlowTrain: a highly parallelized and modular fluidic system for studying exometabolite-mediated inter-organismal interactions - Nature Communications Metabolic interactions shape ecosystems but remain hard to study. Here, authors present MetaFlowTrain, a modular, low-cost fluidic system controlling metabolic fluxes between microbes, and show its va...

📣Paper Alert! 📣New publication out by @hacquardst.bsky.social and his team on the development of MetaFlowTrain – a new tool to study metabolic exchange and interactions within microbial communities @naturecomms.bsky.social 👏🥳Congratulations! 👉https://bit.ly/44jnM1H
www.nature.com/articles/s41...

We present MetaFlowTrain, an easy-to-build, highly parallelized, and cost-effective fluidic system for studying microbial exometabolites and their roles in modulating microbe–microbe–host interactions. Kudos to @chesneau-g.bsky.social @mpipz.bsky.social
Give it a try: www.nature.com/articles/s41...

a brown horse is running across a dry grass field . ALT: a brown horse is running across a dry grass field .

How did horses become so athletic? In part, a mutation that should have cut a key protein short instead makes it more sensitive to the stress of exercise. That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪🐴

Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...

Finally!
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...

Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...

📣Paper Alert! New publication @science.org by the group of @tonnigrubeandersen.bsky.social @mpipz.bsky.social, colleagues @ucph.bsky.social & others on the Casparian strip and its role in metabolic trade between plants & bacteria. 👏Learn more 👉https://bit.ly/4bJe4Yd
www.science.org/doi/10.1126/...

Postdoctoral Researcher (Faulkner Group) | John Innes Centre An exciting opportunity has arisen for a Postdoctoral Researcher to join the Faulkner Group at the John Innes Centre, working on cutting-edge science in the field of Cell & Developmental Biology.

We're looking for a postdoc to join the lab to work on cell-to-cell communication via the apoplast. Candidate must be brave, as they will have to lead us (me) away from the plasmodesmata-lands we've inhabited for so long!

www.jic.ac.uk/vacancies/po...

Poke bacteria with a sharp needle and they poke back in just a few seconds!
Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage!
Collaboration with Rod Lim's lab @biozentrum.unibas.ch

www.science.org/doi/10.1126/...

Ancient humans used bone tools one million years earlier than thought Objects discovered in Tanzania and dated to 1.5 million years ago help to rewrite human ancestors’ use of carved bone implements.

🧪 Homo erectus crafted specialized tools out of the bones of elephants and hippos. Read all about it in my latest for Nature. #scicom #paleo www.nature.com/articles/d41...

TIR1-produced cAMP as a second messenger in transcriptional auxin signalling - Nature cAMP produced by the TIR1/AFB receptors of the main endogenous developmental plant hormone auxin acts as a true second messenger, revising the established paradigm of transcriptional auxin signalling.

Wow, cAMP production appears to be the key for activating canonical auxin signalling, not AUX/IAA degradation!

Also annoying - I need to revise quite a many teaching slides to update auxin signalling 😀
www.nature.com/articles/s41...

Solanum pan-genetics reveals paralogues as contingencies in crop engineering - Nature Gene duplication and subsequent paralogue diversification are major obstacles to genotype-to-phenotype predictability.

🚨New paper published in @nature.com! Using pan-genetics across the Solanum genus🍅🥔🍆we reveal why gene duplications🧬are major contingencies in crop engineering. My postdoc work in the Lippman lab @CSHL, collab. with @katiejenike.bsky.social @mikeschatz.bsky.social chatz.bsky.social and many others!

Vacancy — PhD Candidate Microbial Host Preference in Plant Stress Resilience Are you an early-career researcher with a passion for plant science? Would you like to apply your enthusiasm to a highly relevant project in the field of plant-microbiome interactions? Then we have th...

📌Vacancy at the University of Amsterdam!
Join us at the Green Life Sciences with three open positions by my colleagues. 🌱🌻
1/3
PhD position on "Microbial Host Preference in Plant Stress Resilience" in the group of Dr. Kathrin Wippel: werkenbij.uva.nl/en/vacancies...

Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota Nature Plants - The authors show that immunosuppression is highly conserved in the bacterial order Xanthomonadales. This feature, which preceded their specialization as host-adapted pathogens,...

Congratulations to Jana Ordon and all coauthors!!! Our new study is published in @natureplants.bsky.social
"Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota" (0/n)
rdcu.be/eauzt

A bi-kinase module sensitizes and potentiates plant immune signaling Mutual activation of a Ca2+ sensing bi-kinase module potentiates NADPH oxidase activation to facilitate systemic immunity.

Please read here about our collaborative work with Ag Kudla @uni-muenster.de on the phosphocode of these two Calcium-dependent kinases. With the power of MS-based functional #proteomics www.science.org/doi/10.1126/...

Building microbial synthetic communities: get inspired by the design of synthetic plant communities In the last decade, the generation of host-associated microbial culture collections has allowed the fine disentangling of complex relationships between commensal microbes and their hosts, and within-...

Happy to share this viewpoint, written together with @fabriceroux7.bsky.social and Fabienne Vailleau @lipme-toulouse.bsky.social

nph.onlinelibrary.wiley.com/doi/10.1111/...

1/4

The Marchantia polymorpha pangenome reveals ancient mechanisms of plant adaptation to the environment - Nature Genetics Pangenome analyses of 133 wild accessions of the model bryophyte Marchantia polymorpha identify adaptive features and provide insights into the mechanisms of plant adaptation to the terrestrial enviro...

I’m super happy to have a great part of my PhD work (under the wonderful supervision of C. Libourel @pierremarcdelaux.bsky.social & @maximebonhomme.bsky.social) now out in @naturegenet.bsky.social !
Here’s a little thread (1/18)
www.nature.com/articles/s41...

I would love to join!

We continue to build the Plant Microbiome Starter Pack. Please let us know if you or others are missing! go.bsky.app/QG4wCyf

Exogenous bacterial cellulose induces plant tissue regeneration through the regulation of cytokinin and defense networks Bacterial cellulose application concurrently targets cytokinin- and ROS-associated defense responses to induce plant regeneration.

Have a look at our new story on how Bacterial Cellulose works miracles in plant wound healing by activating regeneration via concurrent activation of ROS, defense and cytokinin signalling. In collaboration with @cbgpmadrid.bsky.social @icmabcsic.bsky.social
www.science.org/doi/10.1126/...

Balanced plant helper NLR activation by a modified host protein complex - Nature In Arabidopsis, mechanisms for NRG1A activation by recognition of a modified host EDS1–SAG101 complex, and NRG1A inhibition by NRG1C through sequestration of activated EDS1–SAG101, show activation and...

🔊Paper Alert - New publication out @nature.com by the Parker Lab @mpipz.bsky.social and colleagues at Westlake University on the fine tuning of plant immunity regulation 🌿🪴Congratulations 👏 👏 Learn more here 👉 bit.ly/3WZjrfw #plantsci #immunity

www.nature.com/articles/s41...

Evolution of interorganismal strigolactone biosynthesis in seed plants Strigolactones (SLs) are methylbutenolide molecules derived from β-carotene through an intermediate carlactonoic acid (CLA). Canonical SLs act as signals to microbes and plants, whereas noncanonical S...

Evolution of interorganismal strigolactone biosynthesis in seed plants www.science.org/doi/10.1126/...

I'm very happy to report that Matt Schechter's PhD work is now online as a pre-print:

"Ribosomal protein phylogeography offers quantitative insights into the efficacy of genome-resolved surveys of microbial communities", www.biorxiv.org/content/10.1...

Here's a little 🧵 about it.

Inspired by @mads100tist.bsky.social I'm going to do threads on parts of the publishing process we often get asked about. These will be from my perspective @naturecomms.bsky.social and based on my own opinions, so keep your salt handy.

My new dark red climate stripe for 2024 shows it’s the hottest year yet These ‘warming stripes’, adopted around the world as a symbol of climate awareness, action and ambition, now include another dark red stripe for 2024.

The data is in.

2024 was the warmest year on record, and probably in the whole of human history – about 1.6°C warmer than the pre-industrial period.

More than 1 billion individual thermometer measurements have been condensed into a single vital number.

theconversation.com/my-new-dark-...

Such a game changing set of innovations to be able to fully 3D print these microscopes. Think about all the cool science that this unlocks, especially beyond the traditional style of microscopy 🧪

Non-adapted bacterial infection suppresses plant reproduction Non-adapted bacterial infection represses nonhost plant’s reproduction rather than induces disease.

#weekendreading 🔬

Non-adapted bacterial infection suppresses plant reproduction

in Science Advances #microsky

www.science.org/doi/10.1126/...