Aude Bernheim

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.

Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.

A thread 1/8

Bacterial networks #BacNet26 in September 2026 will be chaired by @lalouxlab.bsky.social and co-chaired by @s-lab.bsky.social with @coralietesseur.bsky.social

Sneak peak on invited speakers and preliminary program:
meetings.embo.org/event/26-bac...

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

Akin to bacterial SIR2 antiphage proteins, human SIRal, also known as FAM118b, forms filaments that are essential for its NAD processing activity.

Awesome to see structures of these filaments that differ from bacterial ones.

Congrats to the authors on this beautiful study.

Filament formation and NAD processing by noncanonical human FAM118 sirtuins Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...

Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.

Are you passionate about the mathematics of data science, computational geometry and topology and want to apply your skills to a beautiful biological question?

Come do a PhD with us!

You will help us understand of how boundaries are established and maintained in early heart development.

Congrats Owen!

Recurrent acquisition of nuclease-protease pairs in antiviral immunity Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...

Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...

Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social

An incredible honor for an incredible scientist!
Congratulations Nitzan 💫👏

Such an elegant mechanism. Perfect to make November more fun.

Also, we wrote a review about NAD+ and bacterial immunity, that came out last month. Thanks Ilya for making it outdated already :).

Congrats to everyone for a beautiful discovery!

Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides.
Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...

Yes!

Done!

Cool idea !

It's self evaluation :)

Done!

Done!

Done!

Done!

Haha yes we should a year when the lads were established and let people decide :)

This is searchable by country, PI career stage and gender.

As a student, find a lab in your country or discover labs you did not know about.

As an editor or conference organizerYou can use this to diversify your reviewer and speaker pool !

Labs in bacterial immunity

Hi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79).

Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky

Exciting day for the lab: our 1rst paper is officially out in @currentbiology.bsky.social 🥳 Wonderful collaboration wt @gautamdey.bsky.social showing how Cryo-ExM achieves consistent immunostaining in diverse diatoms, from the lab and the natural environment 1/n
#ProtistsOnSky
tinyurl.com/2zxaund7

NAD+ is a central molecule in bacterial immunity. An excellent and timely review by Hugo Vausset and Aude Bernheim

Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out:

www.nature.com/articles/s41...

Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social

The multifaceted roles of NAD+ in bacterial immunity In this review, Vaysset and Bernheim examine how nicotinamide adenine dinucleotide (NAD+) is a key player in diverse and widespread bacterial antiphage defense systems and phage counterdefense. The au...

Many antiphage systems use NAD+, in many ways.
@hugovaysset.bsky.social reviewed them all!

Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...

🦠🐘 From bacteria to the elephant ... with a twist. Eukaryotic telomerases originate in antiphage reverse transcriptases 🤯.

Mindblowing discovery from @stephentang23.bsky.social @sternberglab.bsky.social.
Such an incredible exaptation event uncovered through molecular genetics and genomics.

Perfect timing in the field for a beautiful review on NAD+ in bacterial immunity by @hugovaysset.bsky.social and @audeber.bsky.social @cp-molcell.bsky.social

#MicroSky

www.cell.com/molecular-ce...

Six Pasteur scientists win 2025 L’Oréal-UNESCO Young Talents! 🌟 Yolène: Caribbean plants vs dengue mozzies; Leah: gastruloid biophysics; Marion: cancer immunotherapy; Eulalie: menstruation genetics; Sabrina: fixing hearing nerve; Marie: TB & sarcoid immunity. #WomenInScience

Thank you to the Blavatnik Family Foundation and The New York Academy of Sciences for honoring our research uniting human innate immunity and bacterial anti-phage defense at @danafarber.bsky.social @harvardmicro.bsky.social @harvard.edu

bit.ly/4pZUDkF

blavatnikawards.org/news/items/t...