Jonathan Kipnis

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Thank you for inviting me back!

In his “Neuroimmunology” lecture, @jonykipnis.bsky.social (@washumedicine.bsky.social) questioned what makes the CNS “immune privileged” if its antigens reach T cells via lymphatics and meningeal APCs—reshaping how we think about brain-immune interactions. #AAIcourses

Mast cells regulate the brain-dura interface and CSF dynamics Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...

Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...

Brilliant ⁦‪BIG center seminar by ex-postdoc fellow, now associate professor ⁦‪@MayoClinic‬⁩, @da-mesquita.bsky.social, who was our student-invited speaker. 👏👏👏

Here is another reason to come back to Twitter 😂

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting - Nature Neuroscience The authors describe a mechanism for the clearance of macromolecules from cerebrospinal fluid in which macromolecules traverse from periarterial to perivenous spaces, at sites where intersecting lepto...

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting

@jonykipnis.bsky.social

www.nature.com/articles/s41...

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

🔗 By @leonsmyth.bsky.social & @jonykipnis.bsky.social at Nature Reviews Immunology: www.nature.com/articles/s41...
(10/11)

Haha! I need to come here more often to check on my posts 😂… not every day I get a Nobel Laureate comment 🤩! So, as far as I’m concerned, this one is now my #1 post of all times! And I do miss you on Twitter!

Dear all, come back to Twitter. It’s more exciting there!

Check out our special issue! The beautiful cover was designed by @ella-maru.bsky.social, working with @jonykipnis.bsky.social & Mitchell (Min Woo) Kim. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...

What’s better than The Great Nerve by the amazing Kevin Tracey? Two copies of The Great Nerve 🤩 One for home and one for the lab! Amazing read and truly incredible science!

Meningeal lymphatics-microglia axis regulates synaptic physiology Dysfunctional meningeal lymphatics interfere with the inhibitory synaptic inputs and disrupt excitatory/inhibitory balance on cortical neurons in a microglia-IL-6-dependent manner. Enhancing the funct...

and how dysfunctional meningeal lymphatics regulate synaptic physiology in a microglia-dependent manner
www.cell.com/cell/fulltex... @jonykipnis.bsky.social

The new issue is out! 👉 cell.com/cell/current

On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops

📷credit: Andreas Brunner.

May issue is online! Explore reviews on the #neuroimmune axis! The beautiful cover was designed by Ella Marushchenko, working with @jonykipnis.bsky.social. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...

Glymphatics and meningeal lymphatics unlock the brain-immune code Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates an ...

Review @cp-immunity.bsky.social @jonykipnis.bsky.social
Glymphatics and meningeal lymphatics unlock the brain-immune code
www.cell.com/immunity/ful...

Love the cover 🤩 Cracking neuroimmune code!

Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025

Excited having this review with Mitch Kim on glymphatic, brain clearance, and neuroimmunology published.

Glymphatics and meningeal lymphatics unlock the brain-immune code Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates an “immune code” that, when presented by meningeal antigen-presenting cells, instructs T cells to safeguard neural homeostasis. They review how inflammation, aging, and neurodegeneration disrupt this finely tuned process and highlight emerging therapeutic opportunities.

Online now: Glymphatics and meningeal lymphatics unlock the brain-immune code

The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases
A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

#ReThinkNeuroimmunology
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/

Thank you for inviting me! Great visit 🙏

Amazing talk on “New insights into the anatomy of ‘brainwashing’” by Jonathan Kipnis @jonykipnis.bsky.social from @washumedicinebsky.social at #CNIC today 🙇🏼‍♀️🙇🏼‍♀️👏🏻👏🏻👏🏻👏🏻

🚨Registrations now live!
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/

.@washumedicine.bsky.social @weizmanninstitute.bsky.social @genelayinstitute.bsky.social @massgenbrigham.bsky.social

ReThink - The Gene Lay Institute

‼️BIG news ‼️
#ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing!
Hurry up to register while prices are low!
See you in Boston in October!
genelayinstitute.org/rtn/

Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...

Unlock Day On Mar 25, every unlock emoji you share donates 1 day of education to someone in prison, a statement to leaders you want them to unlock it for a million people in prison who don't have it.

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