Ian Kremer

He Was Expected to Get Alzheimer’s 25 Years Ago. Why Hasn’t He?

Scientists are searching for the secret in his biology that has protected him from dementia, hoping it could lead to ways to treat or prevent Alzheimer’s for many other people.

#Alzheimers #dementia #biology #science #neuroscience #NeuroSkyence

photo of supplements

Debunking the link between calcium supplements and dementia www.ecu.edu.au/newsroom/art... by @edithcowanuni.bsky.social

#Alzheimers #dementia #supplements #health #science

Profile – Dr Maria Teresa Ferretti, Karolinska Institutet - DEMENTIA RESEARCHER Dr Maria Teresa Ferretti, Clinical Ops & Partnerships Manager at Syntropic Medical, neuroscientist with 20+ yrs in Alzheimer’s, expert on sex & gender.

Next week we launch a new podcast series with
@laura-sofia-s.bsky.social XXplored: Women's Brain Health. Meet our next guest on episode one - Dr Maria Teresa Ferretti, Karolinska Institutet.

www.dementiaresearcher.nihr.ac.uk/profile-dr-m...

Happy Birthday, John Cougar Mellencamp! 🎶
What's one of your favorite Mellencamp tunes? 🎶
Born in Seymour, Indiana, on October 7, 1951, Mellencamp is a singer, songwriter, artist, activist, and one of the original founders of Farm Aid in 1985. He found mainstream success in the late 1970s & early 👇

Michael Kremer received the 2019 Nobel Prize in Economic Sciences along with Abhijit Banerjee and Esther Duflo for developing an experimental approach to alleviating global poverty. Their work involved designing targeted field experiments to find effective solutions for issues like child health and education deficiencies, leading to widely adopted anti-poverty programs and policies. This photo shows Kremer receiving the prize from the King of Sweden, Carl XVI Gustaf.

I've never won a #NobelPrize, but I'm proud (not jealous) of those who have. In 2019, I was privileged to be in the audience to see my brother (Michael Kremer) receive the Nobel Prize in economics for his work (along with colleagues) to alleviate global poverty by improving health and education.

Opinion | Six surgeons general: It’s our duty to warn the nation about RFK Jr. We took an oath to declare dangers when we found them. We’re doing that again today.

"Secretary Kennedy is entitled to his views. But he is not entitled to put people’s health at risk. He has rejected science, misled the public and compromised the health of Americans." wapo.st/3VTALll

#publichealth #health #science

Scientists reverse Alzheimer’s in mice using nanoparticles - Institute for Bioengineering of Catalonia An international team co-led by the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital Sichuan University (WCHSU) was able to reverse Alzheimer’s in mice after only 3 injecti...

Scientists reverse Alzheimer’s in mice using nanoparticles ibecbarcelona.eu/consiguen-re... via @ibecbarcelona.eu

#Alzheimers #dementia #bioengineering #science

COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years - npj Dementia npj Dementia - COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years

COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years nature.com/articles/s44...

#COVID #coronavirus #dementia #health

"All public high schools and districts can register with The Atlantic to give their students, teachers, and administrators unlimited access to TheAtlantic.com while on campus at no cost: all articles, full magazine issues, podcasts and audio articles, Atlantic Games, and the complete archive."

Steven Beschloss Follow @stevenbeschloss.bsky.soci.. Don't just say DEl as if it's a bad word. Spell it out. Say diversity, which is the lifeblood of American society & culture & innovation. Say equity, which a just society should pursue. Say inclusion, because decent people believe in increasing belonging, not isolating people who are different.

"The Little Boy And The Old Man" by Shel Silverstein Said the little boy, "Sometimes I drop my spoon." Said the old man, "I do that too." The little boy whispered, "I wet my pants." "I do that too," laughed the little old man. Said the little boy, "I often cry." The old man nodded, "So do I." "But worst of all," said the boy, "it seems Grown-ups don't pay attention to me." And he felt the warmth of a wrinkled old hand. "I know what you mean," said the little old man.

Each of us needs attention, care, kindness, respect, and love.

#Alzheimers #dementia #mentalhealth #autism #kindness #poetry

4 Ways to Get Someone with Dementia to Change Clothes – DailyCaring A common challenge for caregivers is how to get seniors with dementia to change clothes. Get 6 reasons they refuse & 4 ways to encourage changing more often

4 Ways to Get Someone with Dementia to Change Clothes dailycaring.com/4-ways-to-ge...

#Alzheimers #dementia #caregiving

75% of high-risk older adults with pneumonia admitted to U.S. hospitals did not receive any dysphagia services. #geriatrics #SLP #speechtherapy, #SLPeeps agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

Please check out my (long overdue!) latest Starter Pack. It is chock full of some of my favorite Blue Sky posters and some of my newer friends. I hope you will love following them, I know I do! 🙏💞🌊😽 See you online! KKG

go.bsky.app/AmnHaxi

a pink panther giving a thumbs up with the words gracias gracias behind him Alt: a pink panther giving a thumbs up with the words gracias gracias behind him

A joy to be in such lovely company! Deepest gratitude, my friend. :-)

a fish tank with the words thank you written in the water Alt: a fish tank with the words thank you written in the water

Grateful for you, dear Monica!

Trump plan would limit disability benefits for older Americans Trump administration officials are considering eliminating age as a factor in deciding whether someone is capable of working.

Trump plan would cut Social Security Disability eligibility, causing 750,000 fewer people to be eligible and 80,000 fewer widows and children to receive benefits due to loss in eligibility of a spouse or parent wapo.st/4qa8yoq

#SocialSecurity #disability #health #retirement #economics

"Don't argue...it's their reality. But you can promise. Promise always with a hug, a kiss, or squeezing their hand, because it calms them." ~ Eunice G.

Learning to replace argument with reassurance can be as hard as it is worthwhile.

#Alzheimers #dementia #caregiving #quote

Creativity could be prescribed to improve brain health, study suggests Music, dance, visual arts, and even specific video games can slow brain ageing, Trinity College research finds

Creativity could be prescribed to improve brain health, study suggests irishtimes.com/health/2025/... by @irishtimes.com

#Alzheimers #dementia #health #wellness #music #art #dance

Illustration comparing anti-amyloid antibody with and without the "brain shuttle" technology.

Potential Alzheimer’s treatment, trontinemab, hits the news – how does it work and is it available? www.alzheimersresearchuk.org/news/potenti...

#Alzheimers #dementia #neuroscience #NeuroSkyence

Q&A: Early detection, patient and caregiver support, keys to future of Alzheimer’s care Over 7 million Americans are living with the progressive and debilitating cognitive impairments caused by Alzheimer’s disease, according to data from the Alzheimer’s Association.Moreover, ...

Q&A: Early detection, patient and caregiver support, keys to future of Alzheimer’s care healio.com/news/primary... by @gohealio.bsky.social

#Alzheimers #dementia #caregiving #geriatrics #MedSky #GeriSky

"What we need is a cup of understanding, a barrel of love, and an ocean of patience." ~ Saint Francis de Sales

In caring for loved ones with dementia, perhaps an ocean of understanding, an ocean of love, and an ocean of patience.

#Alzheimers #dementia #caregiving #quote

TTUHSC Researchers Find Blood-Brain Barrier Remains Resilient in Alzheimer’s Disease Model A team of scientists at TTUHSC has published new evidence suggesting that the brain’s protective shield remains largely intact in a commonly used mouse model of Alzheimer’s disease.

Researchers Find Blood-Brain Barrier Remains Resilient in Alzheimer’s Disease Model dailydose.ttuhsc.edu/2025/septemb...

#Alzheimers #dementia #neuroscience #science #NeuroSkyence

Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease - Molecular Neurodegeneration Background A significant proportion of individuals maintain cognition despite extensive Alzheimer’s disease (AD) pathology, known as cognitive resilience. Understanding the molecular mechanisms that protect these individuals could reveal therapeutic targets for AD. Methods This study defines molecular and cellular signatures of cognitive resilience by integrating bulk RNA and single-cell transcriptomic data with genetics across multiple brain regions. We analyzed data from the Religious Order Study and the Rush Memory and Aging Project (ROSMAP), including bulk RNA sequencing (n = 631 individuals) and multiregional single-nucleus RNA sequencing (n = 48 individuals). Subjects were categorized into AD, resilient, and control based on β-amyloid and tau pathology, and cognitive status. We identified and prioritized protected cell populations using whole-genome sequencing-derived genetic variants, transcriptomic profiling, and cellular composition. Results Transcriptomics and polygenic risk analysis position resilience as an intermediate AD state. Only GFAP and KLF4 expression distinguished resilience from controls at tissue level, whereas differential expression of genes involved in nucleic acid metabolism and signaling differentiated AD and resilient brains. At the cellular level, resilience was characterized by broad downregulation of LINGO1 expression and reorganization of chaperone pathways, specifically downregulation of Hsp90 and upregulation of Hsp40, Hsp70, and Hsp110 families in excitatory neurons. MEF2C, ATP8B1, and RELN emerged as key markers of resilient neurons. Excitatory neuronal subtypes in the entorhinal cortex (ATP8B+ and MEF2Chigh) exhibited unique resilience signaling through activation of neurotrophin (BDNF-NTRK2, modulated by LINGO1) and angiopoietin (ANGPT2-TEK) pathways. MEF2C+ inhibitory neurons were over-represented in resilient brains, and the expression of genes associated with rare genetic variants revealed vulnerable somatostatin (SST) cortical interneurons that survive in AD resilience. The maintenance of excitatory-inhibitory balance emerges as a key characteristic of resilience. Conclusions We have defined molecular and cellular hallmarks of cognitive resilience, an intermediate state in the AD continuum. Resilience mechanisms include preserved neuronal function, balanced network activity, and activation of neurotrophic survival signaling. Specific excitatory neuronal populations appear to play a central role in mediating cognitive resilience, while a subset of vulnerable interneurons likely provides compensation against AD-associated hyperexcitability. This study offers a framework to leverage natural protective mechanisms to mitigate neurodegeneration and preserve cognition in AD.

Thrilled to share that our paper “Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease” is now out in Molecular Neurodegeneration!

👉 link.springer.com/article/10.1...

#Alzheimer #Resilience #Neuroscience

Francis Collins, former NIH director on Stephen Colbert.

We will see mRNA research breakthroughs in other countries.The #NIH nurtures medical miracles from spark to treatment- Alzheimer’s to Huntington’s Disease to cancer.

You can’t just turn it off and then on again.

🧪Via @Brianwlegate on IG

Kennedy Fires N.I.H. Scientist Who Filed Whistle-Blower Complaint

Kennedy Fires N.I.H. Scientist Who Filed Whistle-Blower Complaint www.nytimes.com/2025/10/02/h...

Caregiver Tip #53 "When I get overwhelmed, I try to spend time talking to my mom about her life, her memories of her childhood, and her family. When she smiles, it makes my heart smile and I don't feel so overwhelmed." ~ Debbie M.

For so many people living with Alzheimer's disease, the present is confusing and recent experiences are difficult to retain. But older memories can be more vivid, less confusing, and can offer both greater self-confidence and happiness.

#Alzheimers #dementia #caregiving #happiness #quote

YouTube video by WUSA9 The Heart of It: 'Forgetful Friends' unites seniors with Alzheimer's through song

The Heart of It: 'Forgetful Friends' unites seniors with Alzheimer's through song youtu.be/DnQj943EnnQ?...

#Alzheimers #dementia #music #happiness

People with Down syndrome have early neuroinflammation Researchers at the University of São Paulo identify a new factor that explains the high prevalence of Alzheimer’s disease in older people with Down syndrome. The discovery paves the way for disease pr...

Early neuroinflammation in people with Down syndrome may explain high prevalence of Alzheimer's disease agencia.fapesp.br/people-with-... by @agenciafapesp.bsky.social

#Alzheimers #dementia #DownSyndrome #inflammation