Marta Olszewska, PhD

Our new preprint concerning on issues of how positions of chromosomes differ between human sperm fractions acc. to their quality. Enjoy!

Impact of Sperm Fractionation on Chromosome Positioning, Chromatin Integrity, DNA Methylation and Hydroxymethylation Level https://www.biorxiv.org/content/10.1101/2025.06.07.658443v1

If you are an enthusiast of molecular biology and want to reveal the secrets of infertility - join our team!🐭 🔬 🧬 🧫
Open positions for two PhD students.
We guarantee a lot of fun and satisfaction 😁 🎉 💻 🧬 🧪 🧫
More details:

A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

Reposting in case anyone can help 😊

Gene Therapy Lab @uam-ibmib.bsky.social led by Prof. Krzysztof Sobczak is looking for enthusiastic PhD student for the EU MSCA Doctoral Network project on therapeutical potential of antisense oligonucleotides in myotonic dystrophy, check out link for details! #ASO euraxess.ec.europa.eu/jobs/324410

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...

🥂Congratulations to @jzylicz.bsky.social & co for their new study in our journal (@natcellbio.nature.com) showing that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic #StemCells.
@ucph.bsky.social
bit.ly/3EGflmL

Join Embryo Working Group co-chairs Amander Clark and Janet Rossant on 21 April! This webinar will summarize the group’s findings on stem cell-based embryo model research and discuss proposed revisions to ISSCR guidelines 👉 bit.ly/3DuRGoK

@gairdnerawards.bsky.social @uclastemcell.bsky.social

APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons - Nature Communications The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo-EM and biochemical and biophysical assays to show that instead of modifying nucleosome-in...

My most challenging postdoctoral project, where we show that histones but not nucleosomes are polyubiqutinated by the APC/C for a potential proteasomal degradation was just published in @naturecomms.bsky.social
🎉
www.nature.com/articles/s41...

Big shout-out to all co-authors!!!

The 4th Reproductive Aging Conference program is stacked with amazing speakers!

Register today for the only international meeting dedicated solely to mechanisms of reproductive aging.

www.reproductiveagingconference.com

#ReproAging2025

@jennifergarrison.bsky.social @buckinstitute.org

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.

Please amplify. If you are also able to host fly strains, add your name as well.

We have just published our latest work about the different regulatory roles of DOT1L in male germ cells 🎉 find all details on @juliecocquet.bsky.social ‘s thread below 👇🏻

This is figure 1, which shows weighted means for trust in scientists across countries and regions (1 = very low, 3 = neither high nor low, 5 = very high).

What is the state of trust in scientists around the world? A study in Nature Human Behaviour reports on a survey of 71,922 respondents in 68 countries and finds that trust in scientists is moderately high. https://go.nature.com/3PLgKKU 🧪

When the dog bites
When the bee stings
When I'm feeling sad
I simply remember my paper 𝑖𝑛 𝑝𝑟𝑒𝑠𝑠
And then I don't feel so bad

DNA methylation modulates nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos - Nature Communications Here, the authors identify that reduced DNA methylation in developing germ cells alters nucleosome retention in sperm and allows H3K4me3 establishment on paternal DNA in early embryos, highlighting a ...

A big mystery to me is what DNMT3B is doing in the male germline. It's expressed, but there is no strong KO phenotype like the other DNMTs. Antoine Peters and team @fmiscience.bsky.social do careful genetic dissection here, and show that DNMT3B indeed has a role www.nature.com/articles/s41...

The International Workshop | Andrology and Reproductive Medicine Join the international workshop 'Andrology and Reproductive Medicine'. Explore clinically significant issues in the field of male reproductive health.

The International Workshop "Andrology and Reproductive Medicine" is taking place May 9 2025 in Riga, Latvia.
A great selection of speakers including several Andronet members. Details here: ivfriga.lv/en/participa...
The registration dealine is May 1 2025

Medieval crowns of Eastern European royalty hidden in cathedral wall since World War II finally recovered A cache of precious metal regalia recently discovered in a Lithuanian cathedral sheds light on medieval royalty.

The 16th century burial regalia were found wrapped in newspaper dated Sept 1939 and squirreled away in a wall under a staircase in the Vilnius Cathedral's crypt. 🏺🧪

The structural basis for de novo DNA methylation in chromatin www.biorxiv.org/content/10.1...
▶️DNMT3A2/3B3 preferentially binds di-nucleosomes separated by short DNA linkers
▶️Linker length and position of cytosines control DNA methylation
▶️a large fraction of linkers is resistant to DNMT3A2/3B3

@ncngovpl.bsky.social Thanks to NCN I will be able to study human spermatogenesis and oogenesis on knockout mouse models with the spatial transcriptomics resolution 🧬🔬🐭I am pleased to start a new OPUS27 Project 😁

DNA methylation mediates the link between adversity and depressive symptoms - Nature Mental Health Using epigenome-wide mediation analyses to investigate DNA methylation as a path between adversity and depression, the authors found 31 cytosine–guanine dinucleotides (CpGs) associated with risk and 3...

A reason I am very wary of the loose ways we think about 'epigenetics' is because of these kinds of conclusions:

DNA methylation mediates the link between adversity and depressive symptoms.
www.nature.com/articles/s44...

Embryonic Signatures of Intergenerational Inheritance across Paternal Environments and Genetic Backgrounds The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...

📢 Preprint! How does the environment of a father before conception influence offspring?

Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?

We tested this systematically, with intriguing findings & some cautionary tales🧵...

www.biorxiv.org/content/10.1...

This is figure 1, which shows human adipose tissue retains cellular transcriptional changes after BaS-induced weight loss.

Fat tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which might increase the chance of regaining weight, according to a study in Nature. go.nature.com/48ZTVfg

EMBL Jobs We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

My first post on Blue Sky - moving over !

For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...