Genes & Diseases Journal

🎧 NEW PODCAST | The Oncology Journal Club S3E6:
🧬 Non-op management of MMR-deficient tumours
📊 Clinical trial design standards
🎯 HER2-negative metastatic breast cancer
And much more! Listen now 👉 t.ly/XvKag
#Oncology #OncologyPodcast #MedEd #OJC #MedSky #OncSky #CanSky @craigunderhill.bsky.social

Three items: Clinical meaningfulness of serial assessment and rationale for targeted echo, Mavacamten in hypertrophic cardiomyopathy and Cardio-oncology

We're highlighting the sessions you can expect at #BSEcho2025 - and we can't wait to welcome you to Bournemouth!

📢 Next up: take a look at our #TargetedEcho session taking place on Friday 10 October 2025 👇

View the full programme and book your place: www.bsecho.org/bsech...

Using integrated #transcriptome and proteome analyses, scientists from @emorydeptofmed.bsky.social identified and validated eight novel non-classical #CDMarkers that help characterize #MesenchymalStemCells and potentially discriminate #iMSCs from other cell types.
#OpenAccess:
buff.ly/vnN9LqA

This review summarizes the characteristics and roles of #IntratumoralMicrobiota in different #tumor types, highlights the key mechanisms by which they affect tumor occurrence and development, and discusses their #diagnostic, #prognostic, and therapeutic potential in tumors. #medsky

How can patients help shape the future of cancer research?

Join us at our new virtual conference to explore how involving cancer patients in research leads to more meaningful, impactful outcomes.

Learn more and register: eacr.org/conference/p...

𝐁𝐫𝐢𝐧𝐠 𝐘𝐨𝐮𝐫 𝐕𝐢𝐬𝐢𝐨𝐧 𝐭𝐨 𝐭𝐡𝐞 𝐆𝐥𝐨𝐛𝐚𝐥 𝐒𝐭𝐚𝐠𝐞!
#IASLC is seeking dynamic teams of North American members to #co-chair WCLC 2027, in #Denver, CO. Join us in leading the world’s premier #lungcancerconference. Apply by August 6!
➡️ bit.ly/3HfgD9x

📢Hear from Frank-André Siebert, Chair of the GEC-ESTRO Committee, on why you should join us at the 2025 GEC-ESTRO Workshop!
📍 Belgrade, Serbia
📅 19–20 Nov 2025

👉http://bit.ly/3Tdcs0s

#ESTROGEC25

An overview of #DistractionHistogenesis (DH), its applications, cellular responses and mechanisms, functions of key #mechanosensitive channels, and the mechanisms translating mechanical signals into histogenic signals during DH. #medsky
#OpenAccess:

This review explores various #cancer #DrugResistance mechanisms, the structure and functions of #Pseudogenes, and the role of pseudogene-derived lncRNAs in promoting drug-resistance in different cancers. #medsky

#OpenAccess:

This study indicates that circFKBP8 (5S,6) or cFKBP8 promote susceptibility to #chronicunpredictablemildstress in mice, by down-regulating DRD3 expression and its downstream AMPK/mTOR/ULK1 signaling pathway-mediated neuronal #autophagy. #MajorDepressiveDisorder #medsky
#OpenAccess:

C1orf122 promotes #HepatoCellularCarcinoma cell growth, proliferation, & migration, and suppresses #apoptosis via the SRPK1-PI3K/AKT/GSK3β axis, highlighting its potential as a diagnostic or #TherapeuticTarget for HCC. #biomarker #medsky

#OpenAccess:

Nanotechnology, artificial intelligence, and wearables were some of the emerging technologies in cancer care discussed at the latest AACR Patient Advocate Forum. Learn more in Cancer Today magazine: buff.ly/8HexYPv

Artificial sweetener sucralose could make cancer immunotherapy less effective – BioNews Central Sucralose is a popular sugar substitute for people who are cutting calories or managing blood sugar levels, but new research suggests that the artificial sweetener may reduce the effectiveness of cancer immunotherapy. ...

#Sucralose is a popular #SugarSubstitute for people who are cutting calories or managing blood sugar levels, but new research suggests that the #ArtificialSweetener may reduce the effectiveness of #CancerImmunotherapy.
#GutMicrobiome

👉 Dr. Annie Wong, Dr. Kohei Shitara & Prof. Aya El-Helali invite you to submit your abstract to the ESMO Asia Congress 2025! Deadline: 12 August.
⏰ Present your research from 5 to 7 December in Singapore! #ESMOASIA25

🔗 buff.ly/TDiEkBX

TOPK is overexpressed in moderately to poorly differentiated #ColorectalCancer, while its inhibition enhances the sensitivity of CRC cells to #Radiotherapy by suppressing the downstream pathways of #DNADamageResponse. #medsky

Read our #MostDownloaded article: link.springer.com/article/10.1...

Picture of Virginia Pedicord and text reads: Cambridge Immunology Forum 2025, Dr Virginia Pedicord, University of Cambridge, UK, What happens in the gut doesn't stay in the gut: gut feelings in distant immune processes, #BSICambridge25, Join us on 23 September. Also includes logo of British Society for Immunology and Cambridge Immunology Network.

📢 Meet #BSICambridge25 speaker: @pedicordlab.bsky.social

We're pleased to announce that Dr Virginia Pedicord from #CITIID @cam.ac.uk will speak on gut immunity at the 2025 Cambridge Immunology Forum.

🎟️ Secure your early bird ticket: buff.ly/jhoEQJ0

@britsocimm.bsky.social #ImmunoSky

🧬 Over 60% of global liver cancer cases may be preventable by targeting viral hepatitis, alcohol use, and MASLD, according to @TheLancet Commission.

👨‍⚕️ Lead contributors include
Hashem B. El-Serag, M.D., M.P.H. et al.

🔗 Learn more: ascopost.com/news/july-20...

#LiverCancerPrevention #GlobalHealth

Leqembi's Real-World Benefits, Risks Coming Into Focus in Ongoing Studies, Clinical Practice

Neurologists from multiple clinics shared data at AAIC on the Alzheimer's drug's use, shedding light on its safety and efficacy outside of well-controlled trials.

Final opportunity to submit an oral abstract for the leading systems-biology conference in the world. ICSB will be held in Dublin this October and features an exceptional line-up of speakers. Don't miss your chance to join them and share your latest findings

⏩ Still haven't registered for the 20th #ASEICACongress?

🔴 Do not miss it!
📢Outstanding lineup of speakers

Scientific program ⤵️
https://www.aseica.es/aseica-20th-congress

A Stronger Defense | Cancer Today Researchers explore the potential of immune checkpoint inhibitors before surgery to prevent recurrence in several cancers.

“What if you left the cancer in place, turned on the immune system, and said, ‘Go’?” New research examines whether giving immunotherapy before surgery can help prevent cancer recurrence. buff.ly/HaMYJvX

Exogenous administration of pyruvate exerts an anti-inflammatory effect, alleviates symptoms, and preserves the epithelial barrier permeability in DSS-induced colitis by targeting cPLA2. #medsky #InflammatoryBowelDisease
#OpenAccess:
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A review on the effects of #fucosylation in digestive inflammatory diseases and #cancers, focusing on aberrant fucosylated glycans as diagnostic #biomarkers and the therapeutic strategies targeting fucosylation by fucose or fucosylation inhibitors. #medsky
#OpenAccess:

PDE4DIP dysfunction contributes to the pathogenesis of left ventricular non-compaction (LVNC) by regulating cell polarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess:

HER3-targeted patritumab deruxtecan showed efficacy in leptomeningeal metastases from solid tumors in the Phase II TUXEDO-3 trial
📉 65% 3-month survival
🧬 Activity in intracranial lesions
🔷 From Matthias Preusser, MD, et al
🔗 ascopost.com/news/july-20...

Gut microbiome may predict chronic fatigue syndrome and long COVID – BioNews Central New research reveals how myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) disrupts microbiome, immune system, and metabolism interactions, bringing millions closer to personalized care despite diagnostic challenges. ...

New research reveals how #MyalgicEncephalomyelitis / #ChronicFatigueSyndrome (ME/CFS) disrupts #microbiome, #ImmuneSystem, and #metabolism interactions, bringing millions closer to personalized care despite diagnostic challenges.
#GutMicrobiome #LongCOVID 

VERITAS Data Demonstrate Noninferiority of Navigational Bronchoscopy Compared to Transthoracic Needle Biopsy - ILCN.org (ILCN/WCLC) Drs. James Katsis and William Thinnes say the safety profile and ability to stage lung cancer with a single procedure make a bronchoscopic approach the preferred method for lung nodule biopsy.

🔬 New data from the VERITAS trial demonstrate that NB is a safe and effective alternative to CT-guided transthoracic needle biopsy.

🔗 Read more in ILCN: bit.ly/4md0OPt

PDE4DIP dysfunction contributes to the pathogenesis of left ventricular non-compaction (LVNC) by regulating cell polarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess:

Overexpression of menin facilitates the malignant behaviors of #BladderCancer (BLCA) cells by boosting β-catenin via activation of TFAP2C, making it a potential #TherapeuticTarget and prognostic marker for BLCA. #medsky
#OpenAccess:

#WorldHepatitisDay: Let’s pledge to raise awareness, take action and eliminate hepatitis globally.

Submit your #hepatitis-related research to Genes & Diseases for wider visibility. #ImpactFactor 9.4

#OpenAccess: www.sciencedirect.com/journal/gene...