Muriel Perron's Avatar

Muriel Perron

@murielperron.bsky.social

CNRS researcher interested in neural stem cells, retina, and regeneration

254 Followers  |  195 Following  |  8 Posts  |  Joined: 12.11.2024  |  1.8462

Latest posts by murielperron.bsky.social on Bluesky

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Retinal glia regulate development of the circadian photoentrainment circuit Circadian photoentrainment depends on intrinsically photosensitive retinal ganglion cells (ipRGCs), which convey environmental light information to thโ€ฆ

Our latest paper is out! While the circadian photoentrainment circuit has been extensively studied, the mechanisms regulating its development remain poorly understood. Here we show that retinal Mรผller glia play a key role in this process. Check it out! www.sciencedirect.com/science/arti...

29.10.2025 14:27 โ€” ๐Ÿ‘ 39    ๐Ÿ” 13    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 2
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Ran et al. generated a retinal regeneration model and a tumor model using targeted integration in X. tropicalis (PNAS). Kagawa et al. provide a step-by-step protocol for knock-in targeted integration in X. laevis (DGD). www.xenbase.org/xenbase/doNe... #science #devbio #xenopus #frogs

21.10.2025 22:18 โ€” ๐Ÿ‘ 5    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐Ÿ”ฌ Limb regeneration depends on regenerative signaling center cells โ€” but how do these cells influence others to proliferate, migrate, or differentiate?
Weโ€™re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !

21.10.2025 06:56 โ€” ๐Ÿ‘ 19    ๐Ÿ” 17    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
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โ–ถ๏ธ Mark the date! On May 28-29 2026, we will host and organize the next edition of the Chen Institute Symposia: Brain, Behavior & Beyond.

โ–ถ๏ธ This year we will focus on New Horizons in Aging and Neurodegenerative Diseases.

โ–ถ๏ธ Stay tuned as we will soon disclose speakers and more!

08.10.2025 07:14 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging. Biological age is a major risk factor in the development of common degenerative retinal diseases such as age-related macular degeneration and glaucoma. To systematically characterize molecular mechani...

Our latest manuscript is out, and this one tackles the problem of cellular aging in the retina, using comparative multiomic analysis of zebrafish, mouse, and humans. What led us to work on aging after studying development and regeneration? Explainer follows./1
www.biorxiv.org/content/10.1...

12.09.2025 19:04 โ€” ๐Ÿ‘ 74    ๐Ÿ” 21    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2

Fantastic workshop !!!! Thank you again Seth and Michel !!!

06.09.2025 08:12 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐Ÿฅณ Very grateful for the support of the ERC Starting Grant for my newly established lab! We will study how transposable elements contribute to mammalian embryonic development.
We will have positions available next year. Stay tuned!

04.09.2025 13:27 โ€” ๐Ÿ‘ 140    ๐Ÿ” 13    ๐Ÿ’ฌ 25    ๐Ÿ“Œ 1
Tenure-Track Positions in Functional Genomics/Genetics and Systems Biology - Office of the Dean of the Faculty - Reed College

Come be my colleague! We are hiring for two tenure-track positions. www.reed.edu/dean_of_facu...

27.08.2025 18:43 โ€” ๐Ÿ‘ 25    ๐Ÿ” 26    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Early embryonic developmental pathways are activated during regeneration phase in Xenopus ๐Ÿธ
--by Aniket Kshirsagar, Rachel Ronan, Ana Lรบcia Rebelo, Siobhan McMahon, Abhay Pandit, and Gerhard Schlosser

www.sciencedirect.com/science/arti...

#Xenopus #regeneration #DBfeature

09.08.2025 13:31 โ€” ๐Ÿ‘ 13    ๐Ÿ” 6    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Differential regulation of eye specification in Drosophila by Polycomb Group epigenetic repressors Highlighted Article: Distinct gene sets are differentially expressed in response to the knockdown of Polycomb Group (PcG) members, suggesting that multiple avenues may exist for the eye to be transfor...

My lab's newest research paper on the Drosophila eye is published in Development today. Thanks to the editorial staff for writing a research highlight and interviewing us about our work.

journals.biologists.com/dev/article-...

05.08.2025 19:50 โ€” ๐Ÿ‘ 37    ๐Ÿ” 11    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Deadline approaching: 22 Aug 2025!!!
Tenure-track Junior Professor (CPJ) in Multi-omics Cell Atlases of Brain Development
@neuropsi.bsky.social @univparissaclay.bsky.social
Details: www.universite-paris-saclay.fr/sites/defaul...
Apply via ODYSSEE: odyssee.enseignementsup-recherche.gouv.fr

04.08.2025 07:15 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

๐Ÿ”ฌ๐Ÿ We have a new position open!

โžก๏ธ Our "Chaire Professeur Junior" position focuses on multi-omics during brain development. This research-heavy position follows a tenure-track scheme, leading to a full professor position.

๐Ÿ—“๏ธ Application deadline: 22/08/2025

28.06.2025 15:18 โ€” ๐Ÿ‘ 6    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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A tenure track "AI and pathological behavioral trajectories" Professor position is open at NeuroPSI.
Learn more and apply
๐Ÿ”ฝ๐Ÿ”ฝ๐Ÿ”ฝ๐Ÿ”ฝ๐Ÿ”ฝ๐Ÿ”ฝ
emploi.cnrs.fr/Offres/CPJ/C...

21.05.2025 20:01 โ€” ๐Ÿ‘ 4    ๐Ÿ” 6    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Join us next Monday and Tuesday (May the 19-20) for the 2025 joint TCCI/NeuroPSI conference!

This year the conference focuses on Social cognition, Decision making & Communication.

You can still register to attend online: neuropsi-2025.sciencesconf.org

16.05.2025 08:29 โ€” ๐Ÿ‘ 5    ๐Ÿ” 5    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Dr. Dominique Alfandari seeks requests for producing Xenopus antibodies. Fill out the form in the link to make your suggestions. www.xenbase.org/xenbase/doNe... #science #devbio #xenopus #frogs

14.05.2025 15:34 โ€” ๐Ÿ‘ 2    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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A Tenure-track Junior Professor Chair (CPJ) is now open at @neuropsi.bsky.social
Focus: Multi-omics cellular atlases of brain development
Application details & deadline coming soon, stay tuned!
@univparissaclay.bsky.social

16.05.2025 12:38 โ€” ๐Ÿ‘ 9    ๐Ÿ” 9    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Mรผller glia

The final version of our eLife manuscript on viral Oct4-mediated neurogenic reprogramming of retinal Muller glia is now out, with all reviewer comments addressed.
elifesciences.org/reviewed-pre...

28.04.2025 22:07 โ€” ๐Ÿ‘ 11    ๐Ÿ” 4    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
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Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels. Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the rod-dominant retinas of most mammals. The molecular mechani...

Our latest manuscript (7 years in the works) tackles the question of how diurnal ground squirrels evolved a cone-dominant retina, in contrast to the ancestral rod-dominant retina retained by virtually all other mammals./1
www.biorxiv.org/content/10.1...

29.04.2025 11:06 โ€” ๐Ÿ‘ 87    ๐Ÿ” 31    ๐Ÿ’ฌ 6    ๐Ÿ“Œ 2
Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Mรผller glia

Our latest manuscript on glia-to-neuron conversion in retina is out in @elife.bsky.social. We show that AAV-mediated overexpression of Oct4 induces glia-to-bipolar cell conversion in wildtype retina, and that this is greatly enhanced by loss of function of Rbpj.

elifesciences.org/reviewed-pre...

05.04.2025 14:59 โ€” ๐Ÿ‘ 49    ๐Ÿ” 15    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 0
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The Paris-Saclay Institute of Neuroscience @neuropsi.bsky.social has launched a call for new group leaders. Please spread the word!
deadline May 30
neuropsi.cnrs.fr/wp-content/u...
@cnrs.fr @univparissaclay.bsky.social

18.03.2025 07:44 โ€” ๐Ÿ‘ 9    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Le programme de la semaine du cerveau se prรฉcise. Toute la semaine du 10 mars, NeuroPSI et NeuroSPIN vous accueillent ร  tour de rรดle pour une sรฉrie de confรฉrences et d'animation ร  destination de tous les publics !
neuropsi.cnrs.fr/semaine-cerv...

18.02.2025 12:40 โ€” ๐Ÿ‘ 5    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

โ–ถ๏ธ The 2025 TCCI-NeuroPSI conference will take place on May 19-20 at NeuroPSI.

โ–ถ๏ธ Dive with us into the dynamic interactions between social cognition, emotions and communication systems, which enable adaptive choices in complex social environments!

โ–ถ๏ธ Register: neuropsi-2025.sciencesconf.org

25.02.2025 16:58 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

Our new review article with @michelcayouette.bsky.social is out on temporal patterning and glial reprogramming in adult CNS, and its implications for treating degenerative diseases. All work from our lab discussed here was funded by NIH.
authors.elsevier.com/a/1kfup3Q9h2...

25.02.2025 13:30 โ€” ๐Ÿ‘ 27    ๐Ÿ” 10    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2

Happy to share this review that @sethblackshaw.bsky.social and I wrote about temporal patterning and how these mechanisms could be coaxed to stimulate glia reprogramming and CNS regeneration! Access link below, feel free to use the figures in your talks!๐Ÿ˜Š
authors.elsevier.com/c/1kfup3Q9h2...

25.02.2025 14:03 โ€” ๐Ÿ‘ 17    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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UCL โ€“ University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Weโ€™re hiring a new research fellow. Come join us in London to study glial cells in the ageing retina using killifish as a model. www.ucl.ac.uk/work-at-ucl/...

07.02.2025 14:35 โ€” ๐Ÿ‘ 19    ๐Ÿ” 18    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 3
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MetaLigand: A database for predicting non-peptide ligand mediated cell-cell communication Non-peptide ligands (NPLs), including lipids, amino acids, carbohydrates, and non-peptide neurotransmitters and hormones, play a critical role in ligand-receptor-mediated cell-cell communication, driv...

Introducing MetaLigand, our latest collaboration with the Qian group, a database for predicting non-peptide ligand mediated cell-cell signaling.

www.biorxiv.org/content/10.1...

27.01.2025 02:05 โ€” ๐Ÿ‘ 11    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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The correct version of our paper in ScienceAdvances is now live on PubMed! (Yes, our entire Figure 3 had been mysteriously swappedโ€ฆ but it's all fixed now!)
It is about the complex role of inflammation in Mรผller glia response to injury. science.org/doi/10.1126/...
@neuropsi.bsky.social

29.01.2025 08:37 โ€” ๐Ÿ‘ 17    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
"ร€ la dรฉcouverte de nos diffรฉrences grรขce aux souris" - Les visites du Gircor
YouTube video by Gircor "ร€ la dรฉcouverte de nos diffรฉrences grรขce aux souris" - Les visites du Gircor

๐Ÿ Dรฉcouvrez notre animalerie et certaines des recherches qui y sont menรฉes dans cette nouvelle video de la sรฉrie "Les visites du GIRCOR"!

24.01.2025 11:43 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Semaine du Cerveau 2025 - Institut des Neurosciences Parisโ€‘Saclay La Semaine du cerveau 2025 est organisรฉe conjointement par NeuroSpin (Institut Joliot) et par l'Institut NeuroPSI. Programme prรฉvisionnel du 10 au 14 mars 2025 Pour la deuxiรจme annรฉe consรฉcutive, la...

๐Ÿ—“๏ธ La prochaine Semaine du Cerveau c'est du 10 au 14 mars prochain.

๐Ÿง Rejoignez-nous ร  NeuroPSI, en partenariat avec Neurospin et @cea-joliot.bsky.social, pour de nombreuses confรฉrences et animations!

Suivez-nous ici pour en savoir bientรดt davantage...

24.01.2025 12:26 โ€” ๐Ÿ‘ 4    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐Ÿ—“๏ธ On the 19th and 20th of May 2025, we will host the 3rd edition of the joint TCCI - NeuroPSI international conference.

โ–ถ๏ธ This year topic will be Social cognition, Decision making & Communication.

โ–ถ๏ธ Stay tuned for our speakers list, registration and more!

27.01.2025 14:01 โ€” ๐Ÿ‘ 4    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

@murielperron is following 20 prominent accounts