Jaime de Juan-Sanz

⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?

Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk

Tested by @ycharos.bsky.social & @oga-community.bsky.social

BBC Inside Science - The science behind autism - BBC Sounds What do we know about the causes of autism?

What do we know about the causes of #autism? @kingscollegelondon.bsky.social Professor Laura Andreae speaks with BBC Radio 4's Inside Science about the genetic factors behind autism, particularly around twin studies.

🔊 Listen now: www.bbc.co.uk/sounds/play/...

Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity - Nature Communications This study investigates the developmental transcriptional regulation of mitochondrial quality control. Authors identify the Drosophila factor Mirana, homologous to mammalian TZAP, as a key temporal re...

Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social
labs
www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!

Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.

www.nature.com/articles/s41...

ER_2025 #endoplasmicreticulum #ER #conference Paris October 8-10 2025 Register! itbcrde.inserm.fr/index.php?page…

Another example! 🚲🚲🚲

Always faster to 🚲 in Paris!

Nicer pics from the @academiesciences.bsky.social ceremony - a great occasion to celebrate our recent work together with @stefvass.bsky.social @florianwerner.bsky.social and @moparthisk.bsky.social!
Photos © Académie des sciences – Mathieu Baumer.

Had a blast in the SynAnb/generate symposium in Tutzing! Lots to learn about the relationship between the immune system and the brain (and how things can go south). Thanks for the invite!

Good to know - it could just be bad luck for us!

Thanks - yes n=1 and it is true it's a busy time of the year...

Hi Felix, thanks a lot for the answer! This is great to know! Maybe I have to work on my patience also 😄

20 days waiting for an editorial decision on whether our paper will be sent for review at @elife.bsky.social — did others have a similar experience? I wonder if these long timelines will make it somewhat hard to support the new model

Real fun hosting @chaichinta.bsky.social to discuss how to merge theory and experiments in ATP diffusion in axons. Thanks to @kavlifoundation.org for funding these exchanges!

The Gutting of America’s Medical Research: Here Is Every Canceled or Delayed N.I.H. Grant Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.

"Tanner, a chemist at the Univ. of Mississippi working to develop a novel approach for treating glioblastoma, was notified in April that the grant was terminated.

“I would like to cure brain cancer,” Dr. Tanner said. “I think that's not particularly controversial.”

www.nytimes.com/interactive/...

A really important skill for trainees to learn is to be a “closer” of a project-that is to take it over the finish line for publication. This means doing the experiments, getting the figures/text ready for submission and being prepared to do review corrections 😀

Cool stuff! Congrats!

ATG9A vesicles are a subtype of intracellular nanovesicle Highlighted Article: Presentation of the first intracellular nanovesicle (INV) proteome, showing that a subset of INVs are ATG9A vesicles. This places ATG9A vesicles in a broader superfamily of traffi...

This is a summary of our recent @jcellsci.bsky.social paper.

If you've ever wondered why ATG9A has many and varied roles, we think it's because it is trafficked by a subset of a large, diverse family of vesicles - intracellular nanovesicles.

doi.org/10.1242/jcs....

In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors Dopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex netwo...

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

Memory by a thousand rules: Automated discovery of functional multi-type plasticity rules reveals variety & degeneracy at the heart of learning Synaptic plasticity is the basis of learning and memory, but the link between synaptic changes and neural function remains elusive. Here, we used automated search algorithms to obtain thousands of str...

We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...

Great visit today of @hoppam.bsky.social at the Paris Brain Institute. We learned a lot about K+ channels and the unexpected stuff they do at the presynapse!

Congrats to PSG and all parisians on the big win tonight! Celebrations on the streets of the 11eme district starting! Great to watch with @hoppam.bsky.social

Graphs showing 25 years of budgets for the National Institute of Health, NASA, and the NSF. In all cases, the proposed budget for next year is far, far below any year of the previous quarter century.

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.

A multi-institutional investigation of psilocybin's effects on mouse behavior Studies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, we impleme...

A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄

@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏

www.biorxiv.org/content/10.1...

Friends! Late to the party but finally made the change to bsky! Happy to reconnect with everyone - and just in case this is us! www.dejuansanzlab.org

Friends! Late to the party but finally made the change to bsky! Happy to reconnect with everyone - and just in case this is us! www.dejuansanzlab.org