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Howard Salis

@hsalis.bsky.social

Professor of synthetic biology, biological, & chemical engineering. De Novo DNA founder. Engineering microbes with predictive models & algorithms.

1,210 Followers  |  810 Following  |  116 Posts  |  Joined: 04.09.2023  |  1.858

Latest posts by hsalis.bsky.social on Bluesky

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Synthetic bacterial community colonizes wheat roots grown in soil and mimics the assembly pattern of a field community The root microbiome is important for plant development. The impact of the root microbiome is the sum of multiple complex interactions among microorganisms, the plant and the environment. This complexi...

Synthetic bacterial community colonizes wheat roots grown in soil and mimics the assembly pattern of a field community

bioRxiv from @fredebak.bsky.social et al #NNF_INTERACT

www.biorxiv.org/content/10.1...

24.11.2025 07:43 โ€” ๐Ÿ‘ 8    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Passing through Coralville, IA!
Shout out to IDT!!

27.07.2025 19:18 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

That tiniest of moments when a devops restarts their load balancer

21.07.2025 09:29 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Need to remove any repetitive DNA via redesign โ€ฆ

10.07.2025 16:09 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Putida is also used in bioconversion of cellulosic hydrolysate to FDCA (2,5-Furandicarboxylic acid)

22.06.2025 21:54 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

It's an OK article but the tag line should be "Trump illegally cancels Northwestern's contracts and refuses to pay them", not "Trump blew up Northwestern's business model". If you hold up a bank at gunpoint and abscond with bags of money you're not "blowing up its business model". You're stealing.

15.06.2025 14:15 โ€” ๐Ÿ‘ 18    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

All these ML-centric rewordings of old ideas is getting tired.

Next someone will write a perspective comparing evolution and reinforcement learning.

Or ensemble modeling as wisdom of the crowd.

Boring!

15.06.2025 14:12 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

EPIGENETIC HULK WAS WAITING FOR GREENSKY.

EPIGENETIC HULK THEN REALIZED THAT HIGH-ENERGY SMASH CAUSES BLUE-SHIFT.

MORE SMASH MORE BLUESKY

13.06.2025 18:56 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Every compiler error in tech would be a dead person in biotech.

21.03.2025 01:30 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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What a shitty time to run out.

21.03.2025 00:00 โ€” ๐Ÿ‘ 8    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

As a Jew looking at the administration's sudden "concern" over University antisemitism

10.03.2025 21:16 โ€” ๐Ÿ‘ 10    ๐Ÿ” 3    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
Title, authors and abstract from link

Title, authors and abstract from link

In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...

01.03.2025 13:40 โ€” ๐Ÿ‘ 60    ๐Ÿ” 21    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1
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Could not agree more. The Prez & VP are shameful, embarrassing Putin puppets & a disgrace to our country. ๐Ÿคฎ

#SlavaUkraine ๐Ÿ‡บ๐Ÿ‡ฆ

28.02.2025 21:40 โ€” ๐Ÿ‘ 65859    ๐Ÿ” 12508    ๐Ÿ’ฌ 1615    ๐Ÿ“Œ 439
Post image 27.02.2025 20:36 โ€” ๐Ÿ‘ 165    ๐Ÿ” 34    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 2

Normalize calling Republicans Nazis.

20.02.2025 11:51 โ€” ๐Ÿ‘ 1232    ๐Ÿ” 264    ๐Ÿ’ฌ 15    ๐Ÿ“Œ 6
New York 50th Musical โ€“ SNL50
YouTube video by Saturday Night Live New York 50th Musical โ€“ SNL50

Wowzers the SNL 50th anniversary special was truly fantastic and man did I need to laugh a bit to cleanse the soul after the last two weeks.

My favorite bit: youtu.be/l8GbTZ8v1-w?...

The whole Shebang is streaming on Peacock.

18.02.2025 02:15 โ€” ๐Ÿ‘ 5    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Excellent reason to only use defined, designed barcodes (flanking inserts) and identify/filter out any discordant barcode pairs.

Random barcodes == you never know what you're going to get!

16.02.2025 15:53 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Simultaneous in vitro expression of minimal 21 transfer RNAs by tRNA array method https://www.biorxiv.org/content/10.1101/2025.02.15.638384v1

16.02.2025 06:06 โ€” ๐Ÿ‘ 6    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

I am hearing that about 1/2 of the ARPA-H staff were probationary and are being let go. Many of these folks are long-time NIHers who were promoted into new positions in ARPA-H and became probationary in these new positions despite many years of NIH service.

14.02.2025 20:50 โ€” ๐Ÿ‘ 164    ๐Ÿ” 67    ๐Ÿ’ฌ 10    ๐Ÿ“Œ 11

Today's the day! Getting ready for the workshop on #AI in #Biology. While these fields arenโ€™t new (of course!), the intersection of the two is having a major moment right now.

14.02.2025 07:49 โ€” ๐Ÿ‘ 6    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Ok folks. Time for me to pull my law rank and correct some shit. When a judge issues a civil contempt order, she does not hand it to the prosecutor or AG and say โ€œenforce this if you feel like it.โ€ The judge hands it directly to a law enforcement officer, who has no discretion on whether to serve it

11.02.2025 14:49 โ€” ๐Ÿ‘ 368    ๐Ÿ” 115    ๐Ÿ’ฌ 16    ๐Ÿ“Œ 17
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Thrilled to have @hsalis.bsky.social as the keynote speaker for todayโ€™s workshop on AI in Biology! After a prologue of intense discussions, he follows the tradition of every visitor by stepping onto Km 0 at Puerta del Solโ€”the geographical center of Spain & a place of significance for every Madrileรฑo

14.02.2025 05:18 โ€” ๐Ÿ‘ 6    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Escherichia coli K-12 substr. MG1655 pdeI

I feel sorry for anyone studying phospho-diesterase I (pDEI).

ecocyc.org/gene?orgid=E...

12.02.2025 00:03 โ€” ๐Ÿ‘ 11    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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AAMCOrd021025

BREAKING: Federal judge in Boston broadens block on Trump's NIH grant 15% overhead limit (indirect cost rates) to all recipients nationwide. Doc: www.documentcloud.org/documents/25...
#TROpalooza ain't done

11.02.2025 05:22 โ€” ๐Ÿ‘ 697    ๐Ÿ” 223    ๐Ÿ’ฌ 11    ๐Ÿ“Œ 26

Fucking seriously......

10.02.2025 23:41 โ€” ๐Ÿ‘ 4    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Parties to suit: Massachusetts, Illinois, Michigan, Arizona, California, Connecticut, Colorado, Delaware, Hawaii, Maine, Maryland, Minnesota, Nevada, New Jersey, New Mexico, New York, North Carolina, Oregon, Rhode Island, Vermont, Washington & Wisconsin.

WTF no Pennsylvania???

10.02.2025 23:33 โ€” ๐Ÿ‘ 27    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

What if CA, MA, & other high-GDP states passed State Law to redirect all federal tax collection to a State bureau, which would only redirect taxes to the Fed if Federal Law wasnโ€™t blatantly ignored (by vote of State legislature)?

Another lever of โ€œchecks & balancesโ€ & a โ€œsoft secessionโ€ when needed

09.02.2025 18:14 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Buckle up babes, it's time for a long thread about #USAID. Many of you know I've worked on USAID contracts and in humanitarian aid for the last decade. But very few know why. I studied international security in undergrad and my first job out of school was in the defense/intel world. I hated it. 1/

09.02.2025 14:26 โ€” ๐Ÿ‘ 229    ๐Ÿ” 79    ๐Ÿ’ฌ 9    ๐Ÿ“Œ 16

Canada removed US liquor from all of its stores (something like 30% of US liquor exports).

Even liquor isnโ€™t a safe bet from Trumpโ€™s mayhem. :(

08.02.2025 12:09 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Announcing the Data.gov Archive | Library Innovation Lab Today we released our archive of data.gov on Source Cooperative. The 16TB collection includes over 311,000 datasets harvested during 2024 and 2025, a complet...

We just launched a 16TB archive of every dataset that has been available on data.gov since November. This will be updated day by day as new datasets appear. It can be freely copied, and we're sharing the code behind it to help others make their own archives of data they depend on.

06.02.2025 21:23 โ€” ๐Ÿ‘ 1910    ๐Ÿ” 1006    ๐Ÿ’ฌ 43    ๐Ÿ“Œ 66

@hsalis is following 20 prominent accounts