5/5 Congratulations to the authors🥳
Martina Pfeiffer, Fiona Cole, Dongfang Wang, YonggangKe and @philiptinnefeld.bsky.social

4/5 How? SEPP is a spring-loaded network of DNA “antijunctions” that flip between states, like tiny molecular switches. We can program them with DNA strands to make logic gates, timed actions, and even cargo release. Basically, tiny robots doing science at 1 billionth the size🤏

3/5 Applications? From smart nanosensors to molecular factories and future therapeutics.
We’re one step closer to computers made of DNA — literally. 🧠🧬

2/5 Think “field-programmable gate array,” but at the nanometer scale — powered by fuel strands instead of electricity.
Meet SEPP: the Serial Execution of Programmable Processes platform for modular, logic-gated nanorobots 🤖

Spring-loaded DNA origami arrays as energy-supplied hardware for modular nanorobots Spring-loaded DNA origami arrays enable nanorobots to integrate diverse inputs with logic-based, sequential operations.

1/5🚀🔬 New paper alert!
We built a spring-loaded DNA origami nanorobot that can sense, compute, and act — basically, a molecular PC made of DNA 🧬💻
#DNAorigami #nanotech #robotics #moleculardesign #SciRobotics
www.science.org/doi/10.1126/...

Excited to share — our project from @labtinnefeld.bsky.social with Heinrich Grabmayr from @jungmannlab.bsky.social has been selected for the CeNS Investment Fund from @cens-lmu.bsky.social !

www.cens.lmu.de/en/research/...

4/4 Huge shout-out to the amazing team🥳:
TimSchroeder, Julian Bauer, Patrick Schüler, Jonas Zähringer, Fiona Cole, Giovanni Ferrari, Laura Barnard, Karen Gronbach, Gereon Andreas Brüggenthies, @philiptinnefeld.bsky.social

3/4 MPUs are fully modular🖥️. We built:
✔ All basic Boolean logic gates
✔ Multi-input compact gates
✔ A half adder
✔ Even non-Boolean logic

2/4 🧬💡Molecular Processing Units (MPUs) are integrated on DNA origamis. They switch from transient (0) to stable (1) DNA states via input strand addition. ✨See GIF🔝

1/4 📢🥳now online: BROWNIAN DNA COMPUTING - Unlike fuel-driven molecular computing with high-energy barriers, it exploits thermal fluctuations.
Inputs rectify state access, enabling fast, low-energy computation. 📜More in our preprint: biorxiv.org/content/10.1...

3/3 Congratulations to all the authors for the team work🥳: @renukkayaadav.bsky.social, Kateryna , Mihir, Vivien, Benedikt, Jan, Cindy, Michi, Giovanni, Leonie, Sophia, @glembockyte.bsky.social, Tim Liedl and @philiptinnefeld.bsky.social

2/3 We made a short video📽️that provides a quick summary of the topic.

1/3 🚨🥳New paper out in Advanced Materials!
We bring attomolar, amplification-free DNA detection to the point-of-care using DNA origami nanoantennas.🧬Check it out here: advanced.onlinelibrary.wiley.com/doi/10.1002/...