Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team β this was a real tour-de-force!
02.09.2025 17:26 β π 57 π 24 π¬ 0 π 0@krademaker.bsky.social
π³π± in π¬π§ running scripts π§βπ» and kilometers π Spatial biology and gene expression research in neurodevelopmental disease @ Bayraktar lab, Wellcome Sanger Institute
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team β this was a real tour-de-force!
02.09.2025 17:26 β π 57 π 24 π¬ 0 π 0Bayraktar, Bassett and Lotfollahi labs are studying how neurodegenerative diseases (ALS, PD, AZ) spatially organise π§ π§¬
Join us to generate & analyse wealths of Xenium data:
- Tech specialist: sanger.wd103.myworkdayjobs.com/en-US/Wellco...
- AI postdoc: sanger.wd103.myworkdayjobs.com/en-US/Wellco...
π§ Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at endπ§΅π
16.05.2025 10:04 β π 76 π 29 π¬ 1 π 6How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic π§΅
16.05.2025 11:42 β π 73 π 31 π¬ 6 π 5Iβm happy to share that our scCellFie manuscript is finally on bioRxiv β a project that was an amazing opportunity to return to my roots in metabolism!
We infer metabolic activity from single-cell & spatial transcriptomics π§¬
Read the pre-print hereπ
π doi.org/10.1101/2025...
Our review "Predicting gene expression from DNA sequence using deep learning models" is finally out! π€
14.05.2025 15:43 β π 44 π 11 π¬ 4 π 2Thrilled to share our new @naturecomms.bsky.social study with @sam-n-barnett.bsky.social on early vs late #COVID19 lung damage π«.
Using single-cell & histopathology-informed #SpatialTranscriptomics, we uncovered key biomarkers & immune patterns. Thanks to collaborators, UKCIC & @humancellatlas.org
Another great computational method out of the Bayraktar lab!
Alexander Aivazidis has been a great colleague in our lab and it's amazing to see the capstone of his PhD is now published.
And the talented PhD student Feri from @mhaniffa.bsky.socialβs
lab is running for Refuge:
supporting women and their children to overcome the impact of domestic abuse.
www.justgiving.com/page/feri-to...
Our labβs computational wizard @drjimmylee.bsky.social is supporting Alzheimerβs Research UK: www.justgiving.com/page/jimmy4a...
01.03.2025 14:00 β π 2 π 0 π¬ 1 π 0Next weekend I will run the Cambridge half marathon with @sangerinstitute.bsky.social colleagues πββοΈ
Two amazing people are running for charities, please support them!
This is really horrific. These single cell reference atlases are widely used as is to train all kinds of models! This is one of the reasons I've constantly harping about uniform reprocessing & extremely careful QC of large atlases. 1/
04.12.2024 07:06 β π 144 π 41 π¬ 9 π 4