Jon Davidow

The Erosion of Harm Reduction | NEJM The U.S. administration has continuously chipped away at public health interventions addressing substance use disorders and the opioid crisis, including vital harm-reduction activities.

The Erosion of Harm Reduction | New England Journal of Medicine www.nejm.org/doi/full/10....

Human cortical dynamics of auditory word form encoding Zhang, Leonard, et al. use high-density direct human brain recordings to reveal how the superior temporal gyrus (STG) detects word boundaries in natural speech and encodes whole auditory word forms. N...

Human cortical dynamics of auditory word form encoding

www.cell.com/neuron/fullt...

Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy by disconnecting a significant portion of the cortex. This study shows that the isolated cortex exhibits EEG patterns resem...

Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans | PLOS Biology journals.plos.org/plosbiology/...

Today, a team of scientists led by Jordan DeKraker, Boris Bernhardt and Alan Evans published HippoMaps, an #openaccess toolbox and online data warehouse for the mapping and contextualization of subregional hippocampal data in the human brain.

🧠 rdcu.be/eI1ye

Lots of interesting implications…

Switching from 1% to 2% propofol in ICU sedation cut greenhouse gas emissions, waste, and costs, with savings equal to over seven Paris–New York flights annually, showing concentration adjustment as a path to greener critical care. zurl.co/DHWbi

Extremely inspiring start to #NCS2025 with a presentation of the RECOVER program and consortium, a beautiful multi-d approach to improve the clinical care of people in coma www.med.upenn.edu/recover-prog...

Interesting work helping to move from the subjective to the objective in psychedelic science.

Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised contr... For people with acute ischaemic stroke and atrial fibrillation, early DOAC initiation (within 4 days) reduced the risk of the composite outcome of recurrent ischaemic stroke, symptomatic intracerebral...

Practice changing systematic review and meta analysis, no evidence of symptomatic ICH with early DOAC: www.thelancet.com/journals/lan...

Autoimmune encephalitis-associated epilepsy Nature Reviews Neurology, Published online: 02 May 2025; doi:10.1038/s41582-025-01089-4In this Perspective, the authors provide a detailed description of rare autoimmune encephalitic conditions that present with recurrent seizures that are resistant to immunotherapy, grouped under the term autoimmune encephalitis-associated epilepsy. The article considers the clinical characteristics and pathophysiological mechanisms of these conditions, alongside current knowledge of treatment and outcomes.

ICYMI: New online! Autoimmune encephalitis-associated epilepsy

generalized convulsive status epilepticus update:

feels like it's time to add IV ketamine as a 2nd line agent before intubation 👇

thoughts/opinions?

rationale explained here: pubmed.ncbi.nlm.nih.gov/36609129/

evidence is accumulating eg, pubmed.ncbi.nlm.nih.gov/37610640/ #EMIMCC

Delayed diagnosis of basilar artery occlusion in a 28-year-old postpartum woman - BMC Neurology Background Basilar artery strokes, which are often challenging to diagnose due to their diverse symptoms and uncommon occurrence, demand timely identification to mitigate severe consequences. Case pre...

Proud to share cases which might help to change the outcome for others bmcneurol.biomedcentral.com/articles/10....

Serotonin reduction in post-acute sequelae of viral infection Post-viral syndromes are associated with serotonin reduction, which may contribute to the neurological and cognitive symptoms seen in individuals with Long COVID.

www.cell.com/cell/fulltex...

Lots of serotonergic neuroprotectantive agents to explore.