Höfer Lab

This shows that "abortive infection" phenotypes are not neccessarily in all cases a "last line" of defense, but may be the consequence of mechanisms interferring with early steps in the phage life cycle.
We further show synergy of daunorubicin with RM systems targeting the FST region T5 phages.

👇 - #phage

🚨We are looking for a coordinator located at @uni-wuerzburg.de for our new excellence cluster NUCLEATE - Cluster of Nucleic Acid Sciences and Technologies 👇
www.uni-wuerzburg.de/fileadmin/03...
Deadline: Jan 31 st, 2026

Now finally peer-reviewed and published in @springernature.com Experimental & Molecular Medicine (EMM)🥳:
www.nature.com/articles/s12...

Our story was published back-to-back with the intriguing paper by Kim et al.:
www.nature.com/articles/s12...

#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)

Please RT:
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...

Interested candidates are encouraged to contact me via email for further details.

@spp2330.bsky.social; @mibinet.bsky.social

Many thanks to Katharina Höfer @hoeferlab.bsky.social for giving an inspiring presentation about RNAylation at our annual "Early-Career Microbiologists Symposium" @johninnescentre.bsky.social. Many thanks also to #EMBO @embo.org for supporting this "Young Investigator Seminar".

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views The advent of system-wide proteomic approaches has largely expanded the number of RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming our understanding of biolog...

Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...

This demanding fieldwork is coming to an end – we are excited to dig into the collected samples and data!

Learn more about the research behind the fieldwork here:
mpi-bremen.de/en/Max-Planc...

#CAPSOLUTION @fischerlab.bsky.social @sumayrasultanji.bsky.social @hoeferlab.bsky.social

Lac de Louvie with the snow-covered Grand Combin in the background.

Merci beaucoup à ALTIS et M. Olivier!

A somewhat tricky location for our setup, but it worked!

The samples are all bagged and cooled.

Lac de Louvie (2213 m elevation) was an incredibly stunning place to sample for microbes! Many thanks to altis.swiss for letting us use their maintenance cable car :)
#CAPSOLUTION
@mpimarinemicrobio.bsky.social
@erc.europa.eu
@hoeferlab.bsky.social
@maxemilschon.bsky.social

Lac de Champex in Champex-Lac, a popular tourist destination in summer and winter.

Keeping the samples cool was a new, but weclome challenge for us on this trip.

The largest one of the lacs de Fenêtre, with the Mont Blanc massif just visible on the far right.

Our fantastic sampling crew for the Swiss leg!

Switzerland welcomed us with summer weather and beautiful mountains! We started with the Lac de Champex (1467 m) which is influenced by human activity, and then hiked up to the Lacs de Fenêtre (2465 m) the next day.
#CAPSOLUTION
@mpimarinemicrobio.bsky.social @erc.europa.eu @hoeferlab.bsky.social

Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...

Excited about #ubiquitin and #TPD ?
Then join us tomorrow for the latest instalment of the @danafarber.bsky.social ‬ Targeted Protein Degradation Webinar where Kimberly Stegmaier and I will present our latest work.
dfci.zoom.us/webinar/regi...

Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵

Presenting RISoTTo, a molecular context-aware model for RNA sequence design, building on our work with PeSTo (for protein binding interface prediction) and CARBonAra (for protein design).

📄 Preprint: www.biorxiv.org/content/10.1...
💻 Code & more coming soon!

#RNAdesign #RNAbiology #AI4Science

#phage #phagesky

🔛LOEWE-RobuCop ist online, auch bei proloewe.de !🎯 Ziel von RobuCop @unimarburg.bsky.social ist es, die natürlich Mecha­nis­men d. CO2-Fixierung, Stressantwort-+Resilienz-Mechanismen im Chloro­plasten grundleg. zu🔬untersuchen, um robuste Photo­synthese zu ermöglichen.
➡️ proloewe.de/de/loewe-vor...

Picture of a lot of us nucleic acid chemists in cesky krumlov

What do you call a group of nucleic acid chemists?

Suggestions welcome 🧬❤️

#SCNAC2025
@cjserpell.bsky.social @hoeferlab.bsky.social @boekhovenlab.bsky.social @rentmeisterlab.bsky.social @kgoepfrich.bsky.social @chlab.bsky.social

Michal Hocek telling us a (very big) sword will be used if we go over time on our talks...

The #SCNAC2025 nucleic acid chemistry conference starting off in Czech-style by @hoceklab.bsky.social 🧬🗡

RNA Canada ARN 2025: Design Contest! - RNA Canada ARN Attention RNA Artists! We have exciting news for the RNA Canada! The Outreach Committee is hosting a design contest for RNA-themed merchandise, which will be showcased at future RNA Canada ARN meeting...

Attention RNA Artists! That includes *you*!
The RNA Canada ARN Outreach Committee is hosting a design contest for RNA-themed merchandise, which will be showcased at future RNA Canada ARN meetings and sold in the RNA Canada ARN online store. Deadline June 30th
www.rnacanada.ca/rna-canada-a...

Cancer-fighting immune cells could soon be engineered inside our bodies Nature - Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful therapy to more people.

Manufacturing CAR T cells in the laboratory is expensive and time-consuming.

An in vivo approach could get this powerful therapy to more people
https://go.nature.com/45w5A5w

YES!!!Excellent initiative #Microbes-for-Climate #M4C🦠FUNDED💲💰☺️🤩
The best?🤔The people❤️
Endless gratitude to Tobi & Anke - amazing role models❤️ Love the "thanks BBQ no matter what" spirit from the "Präsidium"! @unimarburg.bsky.social - sure it tasted better as we got it😉😂 #ProfLife #LovelyMarburg🏰❤️

Gruppenbild aus der Exzellenzkommission: GWK-Vorsitzender Falko Mohrs, Bundesforschungsministerin Dorothee Bär, DFG-Präsidentin Katja Becker, Wissenschaftsratsvorsitzender Wolfgang Wick.

Blick in die Exzellenzkommission.

Wir starten in den Auswahltag der #Exzellenzcluster. Heute kommt das Expertengremium u. die für Wissenschaft und Forschung zuständigen Minister*innen von Bund und Ländern zusammen. Ab ca. 17 Uhr geben GWK-Vorsitzender Falko Mohrs u. Forschungsministerin Dorothee Bär die Ergebnisse bekannt.

What a lovely time at @synmikro.bsky.social!

PIs, PhD students, PostDocs and associated members of RobuCop met at the kick off meeting to share ideas, discuss projects and connect with each other🌱🫰
Can't wait for our next meeting!

Thank you @ramona-zuelch.bsky.social for the picture.

A new preprint from the lab in collaboration with Feng Jiang.
www.biorxiv.org/content/10.1...
This is a thread for you if you're interested in secretion systems, phages, and evolution.

The extracellular contractile injection system (eCIS) is a mysterious microbial toxin delivery system.

Excited to announce the Molecular Biology of Archaea (MBoA) 2026!

Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.

Registration is open, look forward to seeing you!
microbialrnameeting.com

What does it mean to be a woman in science 👩‍🔬?
It’s up to you: Join the 9th Women’s Careers and Networks symposium on June 4 and 5 on our Fassberg Campus to explore career opportunities and engage with experts and peers.

Learn more about #WoCaNet2025 here 👉 uni-goettingen.de/de/203891.html

A mathematical model of phage infection allows the extraction of key phage amplification parameters (PHORCE). Top and middle: E. coli growth curves measured by bioluminescence in the presence of the phage Bas04 at all combinations of eight different initial bacterial concentrations (1.1 × 104–1.4 × 106 mL−1, orange to blue) and 10 different initial phage concentrations (2.5 × 103–1.3 × 106 mL−1, light to dark). Bottom left: Schematic of minimal model of phage amplification. Bottom right: Comparison of observed collapse times and collapse times from the model.

PHORCE allows measurement of lytic #phage amplification rates in bacterial populations. @yuvalmulla.bsky.social & co use PHORCE to reveal phenotypic diversity among #Ecoli & #Paeruginosa phages; phage- #antibiotic interactions are mainly determined by the drug @plosbiology.org 🧪 plos.io/3G2myhf