Marshall G Hussain Shuler Lab

Somewhat related - if you ever wanted to talk to someone doing neuro-related work on the faculty of a business school, I have a whole list of them here: sites.google.com/view/ukarma/...

Bad things unfolding at NIH this week. Looks like the Trump admin is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the…... Bad things unfolding at NIH this week. Looks like the Trump admin is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the ...

5 alarm fire at the NIH
Mark pulls the alarm— its wake-up time

www.linkedin.com/posts/markhi...

JL found that OFC neurons are tuned to uncertainty (probabilistic outcomes) during learning and M2 neurons signal certainty instead. Miniscope imaging in rats 🐀 and causal chemogenetic experiments tell the same story. DREADDs experiments by amazing RA @alexyeghikian.bsky.social

We are grateful 🙏🏽 to have our NIDA and NIMH funds unfrozen at UCLA! These grants support this ongoing work and exciting new directions.

Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex - Nature Communications Neural mechanisms underlying flexible learning and decision-making are not fully understood. Using single-cell calcium imaging, authors here found that neurons in orbitofrontal and secondary motor cortex exhibit complementary roles in reward learning, with neurons in the former exerting a sustained role in conditions of uncertainty.

🎇 Excited to finally share JL Romero Sosa’s publication! Results are from single-cell imaging in different subregions of rat frontal cortex during ✨de novo learning. Spoiler: everything is not everywhere all at once www.nature.com/articles/s41...

There is now strong, converging evidence that OFC neurons signal expected uncertainty. We manipulated probabilistic outcomes, and Zhang & Zhou changed reward delay and magnitude, finding OFC neurons dynamically modulate outcome-coding sensitivity based on variance www.science.org/doi/10.1126/...

Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 c...

Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)

Attractors are usually not mechanisms The mathematical objects can not be. And the "attractor models" have not been established as mechanisms in mammals

Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...

If you're interested in moving to Montreal for a postdoc in #NeuroAI or related topics, check out this scholarship opportunity at @fasudem.bsky.social : fas.umontreal.ca/postdoctoral...

And let me know if you'd like to chat about it.

It's not just #NIH. It's not just #NSF. It's not just #NASA.

The whole scientific community has to make clear that all science across fed agencies is being destroyed in the US.

We can't just ask for our particular piece of the pie. The whole pie is being thrown out - saving your bit won't work.

NEW: NSF will be kicked out of their building. Announcement will be made tomorrow by HUD Sec. and Governor of VA. HUD will take over the NSF building over the next two years.

NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."

BREAKING: A federal judge has ordered the Trump administration to restore millions of dollars in canceled grants to University of California researchers, calling the terminations flagrantly illegal and unconstitutional. storage.courtlistener.com/recap/gov.us...

YouTube video by Senator Chris Van Hollen Celebrating Pride in Baltimore

Joined #BaltimorePride50 last week to celebrate #PrideMonth and the idea that everyone must be free to be who they are and love who they love.

I stand with the LGBTQ community in face of attacks from Trump and his cronies. Bullies only succeed when others retreat. We will not.

SCIMaP - Impacts of Federal Cuts to Science and Medical Research Developed by an interdisciplinary research team, this website shows how funding cuts reduce economic activity and employment nationwide

Important update about local impacts of funding cuts.

Depressing but compelling...

Thanks to @joshuasweitz.bsky.social and his team for putting this together.

scienceimpacts.org

Great opportunity here-check it!

A vector calculus for neural computation in the cerebellum Null space theory predicts that neurons generate spikes not only to produce behavior but also to prevent the undesirable effect of other neurons on behavior. In this work, we show that this competitiv...

Neuronal computation in the cerebellum via a vector calculus.

Work of Mohammad Amin Fakharian, Alden Shoup, Paul Hage, and Hisham Elseweifi

www.science.org/doi/10.1126/...

🚨MAJOR BREAKING: The Canada PM had enough of Trump blabbering bullshit and just cut short the press conference.

I don’t blame him.

How Trump Blew Up Northwestern’s Business Model The federal government froze the university’s research funding. It hasn’t offered the school a way to get it back.

“The university is totally keeping us on life support,” said Dr. Daniela Matei, a Northwestern oncologist. “The big question is for how long they can do this.”

www.wsj.com/us-news/educ...

SEN. PADILLA: “Saying I lunged is a lie, but that’s par for the course for this administration… I was behind the cameras listening, and at a certain point hearing Noem say they had to rescue LA from the Governor and Mayor was too much to take. So I raise my voice to ask a question.”

BREAKING: Judge Breyer orders Trump to return control of the National Guard back to California, saying the call-up was illegal. storage.courtlistener.com/recap/gov.us...

Moreover, the Court is troubled by the implication inherent in Defendants’ argument that protest against the federal government, a core civil liberty protected by the First Amendment, can justify a finding of rebellion. The U.S. Reports are chock-full of language explaining the importance of individuals’ right to speak out against the government—even when doing so is uncomfortable, even when doing so is provocative, even when doing so causes inconvenience. See, e.g., Cohen v. California, 403 U.S. 15, 24–25 (1972) (“To many, the immediate consequence of this freedom may often appear to be only verbal tumult, discord, and even offensive utterance. … That the air may at times seem filled with verbal cacophony is, in this sense not a sign of weakness but of strength.”); Tinker v. Des Moines Indep. Cmty. Sch. Dist., 393 U.S. 503, 508 (“But, in our system, undifferentiated fear or apprehension of disturbance is not enough to overcome the right to freedom of expression. Any departure from absolute regimentation may cause trouble. … Any word spoken … that deviates from the views of another person may start an argument or cause a disturbance. But our Constitution says we must take this risk.”); Cox v. Louisiana, 379 U.S. 536, 550–51 (rejecting the argument that a conviction for breach of the peace “should be sustained because of fear expressed by some [onlookers] that ‘violence was about to erupt’ because of the demonstration” and explaining “that constitutional rights may not be denied simply because of hostility to their assertion or

"The Court is troubled by the implication inherent in Defendants’ argument that protest against the federal government, a core civil liberty protected by the First Amendment, can justify a finding of rebellion."

Intro👩🏻‍🔬
I’m a cognitive computational neuroscienctist 🧠 & AI researcher. I combine RL, NN, ML w behavioral & neuro methods to study:
1-how brains learn models of env to plan & remember
2-collective cognition
3-evolution of learning
&
4-build & evaluate AI inspired by 1-3
New: Ecological intelligence🌍

Orbitofrontal-hippocampal state coding dynamics during reversal learning To build an understanding of our world, we make inferences about the connections between our actions, experiences, and the environment. This process, state inference , requires an agent to guess the c...

www.jneurosci.org/content/earl...

NIH chief stands by funding cuts to ‘politicized science’ at tense hearing Jayanta Bhattacharya says the US biomedical agency can’t continue ‘business as usual’ if it wants to restore its reputation.

US senators grilled NIH director Jayanta Bhattacharya at a hearing today about how his professed support for science squares with unprecedented grant terminations at the agency and enormous cuts that have been proposed for its 2026 budget.

https://go.nature.com/3FWM2wN

NIH restores DEI prohibition for grant recipients within hours of rescinding it The NIH rescinded a 7-week-old DEI directive on Monday, only to reinstate it hours later without explanation.

These clowns are exhausting…

The rescinded the rescission…

Within 24 hours…

www.statnews.com/2025/06/10/n...

My message to Trump’s NIH Director? No one in America wants us to do LESS cancer research.

No one is asking Trump to make it harder to cure Alzheimer's disease.

Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.

This is worse than many appreciate because it is not merely a delay. Many institutions such as mine are TERMINATING these otherwise active grants if the NoA is delayed by more than a month because they cannot afford to keep the grant supported personnel on payroll

I listened to Bhattacharya testify at the hearing today, parts of this meandering interview with Huberman, and read his response to the Bethesda Declaration

Collectively, they reminded of this Andrew Carnegie quote: as I get older, I pay less attention to what men say; I just watch what they do

I’m so sorry to hear that. Thinking of you and your family.

Senators press NIH director on killed grants and proposal to slash agency’s funding Bhattacharya says NIH’s final budget will be “a collaboration”

Democrats on a key Senate spending committee today provided a less than warm welcome to the National Institutes of Health director, who was called in to testify about the agency’s 2026 budget proposal.